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Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System
Pages 1-20
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Neurodegenerative Diseases
Clinical Aspects, Molecular Genetics and Biomarkers
Galimberti, Scarpini
Editore
Springer
Anno
2018
Pagine
407
ISBN
9783319729374
170,00 €
DA SCONTARE
This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.
Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
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Diagnosis of Alzheimer’s Disease Typical and Atypical Forms
Pages 21-28
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Genetic Complexity of Early-Onset Alzheimer’s Disease
Pages 29-50
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Genetic Risk Factors for Complex Forms of Alzheimer’s Disease
Pages 51-76
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Role of Cerebrovascular Disease in Cognition
Pages 77-92
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Risk Factors and Prevention in Alzheimer’s Disease and Dementia
Pages 93-112
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Diagnosis of Frontotemporal Dementia
Pages 113-121
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Autosomal Dominant Frontotemporal Lobar Degeneration: From Genotype to Phenotype
Pages 123-145
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Genetic Risk Factors for Sporadic Frontotemporal Dementia
Pages 147-186
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Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models
Pages 187-219
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Fluid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia
Pages 221-252
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Biomarkers for Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Imaging
Pages 253-277
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Genotypic and Phenotypic Heterogeneity in Amyotrophic Lateral Sclerosis
Pages 279-295
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Lewy Body Dementia
Pages 297-312
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Rare Dementias
Pages 313-336
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Neurodevelopmental and Neurodegenerative Alterations in the Pathophysiology of Schizophrenia: Focus on Neuro-Immuno-Inflammation
Pages 337-348
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Parkinson’s Disease: Contemporary Concepts and Clinical Management
Pages 349-378
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Neurodegeneration and Multiple Sclerosis
Pages 379-400
