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This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject.
List of Contributors, vi
Preface, ix
Dedication, x
			1 Pathology of Brain Aging, 1
			Janna H. Neltner and Peter T. Nelson
			2 Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies, 12
			Michel Goedert
			3 Prion Degeneration, 25
			James A. Mastrianni
			4 Excitotoxicity, 37
			Mark P. Mattson
			5 Etiology and Pathogenesis of Parkinson Disease, 46
			Ruth-Mary deSouza and Anthony H.V. Schapira
			6 Parkinson Disease: Treatment Options – Surgical Therapy, 53
			Travis S. Tierney and Andres M. Lozano
			7 Multiple System Atrophy: Clinical, Genetics, and Neuropathology, 58
			Lucia V. Schottlaender, Anna Sailer, Zeshan Ahmed, Dennis W. Dickson, Henry Houlden, and Owen A. Ross
			8 Progressive Supranuclear Palsy, 72
			Huw R. Morris
			9 Dementia with Lewy Bodies, 83
			Rodolfo Savica and David S. Knopman
			10 Corticobasal Degeneration, 93
			Keith A. Josephs, Jr.
			11 Alzheimer’s Disease, 102
			Qurat ul Ain Khan and Neill R. Graff-Radford
			12 Frontotemporal Dementia, 115
			Christian W. Wider, Barbara Jasinska-Myga, Takuya Konno, and Zbigniew K. Wszolek
			13 Prion Diseases and Other Rapidly Progressive Dementias, 126
			Eric Eggenberger and Daniel L. Murman
			14 Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis, 137
			Kevin B. Boylan, Mark A. Ross, and Eric J. Sorenson
			15 Hereditary Spastic Paraplegia, 161
			Pawel P. Liberski and Craig Blackstone
			16 Spinal Muscular Atrophy, 179
			Joseph R. Wooley, Melissa E. Crowder, Noah J. Pyles, and Charlotte J. Sumner
			17 Spinal and Bulbar Muscular Atrophy (Kennedy Disease), 202
			Erich Peter Bosch
			18 Optic Neuropathies, 211
			Desmond Kidd
			19 Peripheral Nerve Neuropathies Including Charcot–Marie–Tooth Disease, 218
			Amelie Pandraud and Henry Houlden
			20 Axonal Loss and Neurodegeneration in Multiple Sclerosis, 238
			Ranjan Dutta, Jacqueline Chen, Nobuhiko Ohno, Daniel Ontaneda, and Bruce D. Trapp
			21 Huntington’s Disease and Other Choreas, 248
			Salman Haider, Edward Wild, and Sarah J. Tabrizi
			22 Spinocerebellar Ataxias, 284
			H. Brent Clark and Harry T. Orr
			23 Ataxia Telangiectasia, 296
			Malcolm Taylor
			24 Niemann–Pick Disease, 303
			Marc C. Patterson
			25 X-linked Adrenoleukodystrophy, 309
			Deborah L. Renaud
			26 Neurodegeneration with Brain Iron Accumulation, Wilson Disease, and Manganism, 317
			Alisdair McNeill
Index, 327
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