Haschek and Rousseaux's Handbook of Toxicologic Pathology, 4th Edition

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Haschek and Rousseaux's Handbook of Toxicologic Pathology, 4th Edition

Volume 1: Principles and Practice of Toxicologic Pathology

Editore

Elsevier

Anno

2022

Pagine

1152

ISBN

9780128210444

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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Edited by Wanda M. Haschek, ?Professor Emerita, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA; Colin G. Rousseaux, Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa, Principal, Colin Rousseaux and Associates, Canada ; Matthew A. Wallig, Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA and Brad Bolon, President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA

Features:

Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology
Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Table Of Contents:

1. Toxicology Pathology: An Introduction

Part 1 Principles of Toxicologic Pathology
2. Biochemical and Molecular Basis of Toxicity
3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective
4. Biotherapeutic ADME and PK/PD Principles
5. Principles of Pharmacodynamics and Toxicodynamics
6. Morphologic Manifestations of Toxic Cell Injury
7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity
8. Carcinogenesis: Mechanisms and Evaluation

Part 2 Methods in Toxicologic Pathology
9. Basic Approaches to Anatomic Toxicologic Pathology
10. Clinical Pathology in Nonclinical Toxicity Testing
11. Special Techniques in Toxicologic Pathology
12. Digital Pathology and Tissue Image Analysis
13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models
14. Biomarkers: Discovery, Qualification and Application
15. Toxicogenomics: A Primer for Toxicologic Pathologists
16. Experimental Design and Statistical Analysis for Toxicologic Pathologists

Part 3 Animal and Alternative Models in Toxicologic Research
17. Animal Models in Toxicologic Research: Rodents
18. Animal Models in Toxicologic Research: Rabbit
19. Animal Models in Toxicologic Research: Dog
20. Animal Models in Toxicologic Research: Pig
21. Animal Models in Toxicologic Research: Nonhuman Primate
22. Animal Models in Toxicologic Research: Non-mammalian
23. Genetically Engineered Animal Models in Toxicologic Research
24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Non-Traditional In Vivo Approaches

Part 4 Practice of Toxicologic Pathology
25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology
26. Pathology Peer Review
27. Pathology and GLPs, Quality Control and Quality Assurance
28. Practices to Optimize Generation, Interpretation, And Reporting of Pathology Data from Toxicity Studies
29. Issues in Laboratory Animal Science that Impact Toxicologic Pathology

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