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Regulation of Sleep and Wake Homeostasis
Pages 3-18
This book is the first to take into account the rapidly growing body of knowledge on the relation between sleep and PD. Gathering contributions from internationally recognized experts, it provides a unique source of in-depth information on sleep and circadian dysregulation in Parkinson’s disease. The book is divided into two parts: the first comprises chapters on normal sleep-wake homeostasis, followed by changes that occur in PD and discussions of available tools for the assessment of sleep-wake cycles in PD. In the second part, sleep and circadian disorders associated with PD are described in individual chapters, including sections on epidemiology, etiology, pathogenesis, differential diagnosis, and treatment. Controversies in the field, such as the relations between cognition and sleep, fatigue and sleepiness, and the potential impact of surgical therapies on sleep-wake cycles are discussed separately. The book closes with a chapter on future directions and unmet needs in the field of sleep, circadian biology and PD. This comprehensive text offers a readily accessible resource for clinicians and researchers alike, addressing the needs of neurologists, sleep and movement disorders specialists, and all trainees and allied health professionals involved in the care of patients affected by Parkinson’s disease.
Regulation of Sleep and Wake Homeostasis
Pages 3-18
Neurochemistry of the Sleep-Wake Cycle in Parkinson’s Disease
Pages 19-33
Impaired Sleep and Alertness in Parkinson’s Disease: “What Did We Learn from Animal Models?”
Pages 35-49
Objective Measures of the Sleep–Wake Cycle in Parkinson’s Disease
Pages 51-60
Subjective Assessment of Sleep and Sleepiness in Parkinson’s Disease
Pages 61-76
Insomnia in Parkinson’s Disease
Pages 79-91
Sleep Disordered Breathing in Parkinson’s Disease
Pages 93-106
Excessive Daytime Somnolence Associated with Parkinson’s Disease
Pages 107-116
Dysregulation of Circadian System in Parkinson’s Disease
Pages 117-129
REM Sleep Behavior Disorder
Pages 131-144
Quality Control for Diagnosis of REM Sleep Behavior Disorder: Criteria, Questionnaires, Video, and Polysomnography
Pages 145-157
Restless Legs Syndrome and Periodic Limb Movements in Parkinson’s Disease
Pages 159-171
Fatigue and Sleepiness in Parkinson’s Disease Patients
Pages 173-181
Cognition and the Sleep–Wake Cycle in Parkinson’s Disease
Pages 183-194
Impact of Surgical Therapies on Sleep and Alertness in Parkinson’s Disease
Pages 195-207
Sleep Disorders in Atypical Parkinsonisms
Pages 209-221
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