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Introduction
Pages 1-6
This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice.
The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice.
This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline.
The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.
Introduction
Pages 1-6
Clinical Risk Factors: Lessons from Epidemiology
Pages 9-22
Disease Modification in Crohn’s Disease
Pages 23-29
Personalized Medicine - Dream or Reality?
Pages 31-44
Clinical Trial Design to Facilitate Biomarker Discovery
Pages 45-53
Luminal Crohn’s Disease
Pages 57-71
Fibrosis and Stricturing Disease in Crohn’s Disease
Pages 73-87
Postoperative Crohn’s Disease
Pages 89-97
Perianal Crohn’s Disease
Pages 99-118
Biomarkers in Acute Severe Ulcerative Colitis
Pages 121-130
Chronic Active Ulcerative Colitis
Pages 131-140
Refractory Proctitis
Pages 141-153
UC Surveillance
Pages 155-167
The Role of Biomarkers in the Ileal Anal Pouch
Pages 169-180
Extra-intestinal Manifestations in Inflammatory Bowel Disease: Diagnosis and Management
Pages 183-189
Primary Sclerosing Cholangitis Overlapping with IBD
Pages 191-204
Pregnancy and IBD
Pages 205-215
Nutrition in IBD
Pages 217-231
Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Thiopurines
Pages 233-241
Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Biologics
Pages 243-255
Drug Toxicity: Personalising IBD Therapeutics – The Use of Genetic Biomarkers to Reduce Drug Toxicity
Pages 257-269
Biomarkers for Remote Monitoring
Pages 271-278
Exposome and Diet
Pages 281-291
The Microbiome in IBD
Pages 293-301
Metabolic Profiling in IBD
Pages 303-312
Innate and Adaptive Immunology
Pages 313-321
Genetic and Genomic Markers for Prognostication
Pages 323-331
Risk Alleles for Drug Targets: Genomic Markers of Drug Response
Pages 333-341
Big Data Meets Real World! The Use of Clinical Informatics in Biomarker Research
Pages 345-352
Bringing It Altogether: A Systems Biology Approach to Biomarkers in Inflammatory Bowel Disease
Pages 353-358
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