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The Clinical Burden of Biliary Disease: A Global Perspective
Pages 1-15
This book addresses the current understanding of the diagnosis and management of biliary disease across all ages, with emphasis on how the latest advances in clinical science may be integrated into current and future therapies. The coverage is wide ranging, encompassing congenital and acquired conditions including cholestatic syndromes, biliary atresia, drug-induced cholestasis, primary biliary cholangitis/cirrhosis, primary sclerosing cholangitis, cholangiocarcinoma, gallstone disease, and autoimmune sclerosing cholangitis. With contributions from basic and clinical scientists, the relevance of state-of-the-art mechanistic biology to diagnosis, treatment, and future opportunities for drug design is clearly explained. The balance between science and clinical practice will ensure that this book makes a lasting contribution to the field. A broad readership will find the book easy to access and a rich source of information on current best practice and evolving management strategies.
The Clinical Burden of Biliary Disease: A Global Perspective
Pages 1-15
The Healthy Biliary Tree: Cellular and Immune Biology
Pages 17-41
Pathological Features of Biliary Disease in Children and Adults
Pages 43-61
Animal Models of Biliary Disease: Current Approaches and Limitations
Pages 63-84
The Microbiome and Human Disease: A New Organ of Interest in Biliary Disease
Pages 85-96
Biliary Atresia: From Pathology to Treatment
Pages 97-116
Drug-Induced Cholestasis: Mechanisms and Importance
Pages 117-128
Primary Biliary Cholangitis: Its Science and Practice
Pages 129-182
Primary Sclerosing Cholangitis (PSC): Current Concepts in Biology and Strategies for New Therapy
Pages 183-218
Cholangiocarcinoma: Disease Pathogenesis and New Treatment Paradigms
Pages 219-228
Gallstone Disease: Scientific Understanding and Future Treatment
Pages 229-241
IgG4-Related Sclerosing Cholangitis
Pages 243-261
Conclusions and Future Opportunities
Pages 263-264
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