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Highlights on Pharmacogenetics and Pharmacogenomics in Depression
Pages 3-16
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Understanding Depression
Volume 1. Biomedical and Neurobiological Background
Kim
Editore
Springer
Anno
2018
Pagine
322
ISBN
9789811065798
170,00 €
DA SCONTARE
This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression. The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.
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Imaging Genetics Studies on Susceptibility Genes for Major Depressive Disorder, the Present and the Future
Pages 17-39
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Gene-Environment Interactions and Role of Epigenetics in Depression
Pages 41-50
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miRNAs As Critical Epigenetic Players in Determining Neurobiological Correlates of Major Depressive Disorder
Pages 51-69
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The Role of Early Life Stress in HPA Axis and Depression
Pages 71-80
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Complex Role of the Serotonin Receptors in Depression: Implications for Treatment
Pages 83-95
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Emerging Role of Glutamate Receptors in Pathophysiology of Depression
Pages 97-105
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New Perspective on mTOR Pathways: A New Target of Depression
Pages 107-114
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Biological Markers to Differentiate the Subtypes of Depression
Pages 115-128
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Structural, Functional, and Molecular Neuroimaging in Depression
Pages 131-143
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Why Do We Need Psychopathology? From the Brain’s Resting State to “Spatiotemporal Psychopathology” of Depression
Pages 145-152
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Neuroimaging in Depression: A Tool Toward Individualized Prediction of Treatment Outcome
Pages 153-160
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Cortical–Subcortical Interactions in the Pathophysiology of Depression
Pages 161-165
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Pathophysiology and Treatment Strategies for Different Types of Depression
Pages 167-176
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The Effect of Neurostimulation in Depression
Pages 177-187
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Chronic Inflammation and Resulting Neuroprogression in Major Depression
Pages 191-196
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Gut-Microbiota-Brain Axis and Depression
Pages 197-207
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Modulating Microglial Activation As a Possible Therapeutic Target for Depression
Pages 209-219
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Experimental Animal Models for Depressive Disorders: Relevance to Drug Discovery
Pages 221-231
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The Use of Animal Models in Defining Antidepressant Response: A Translational Approach
Pages 233-242
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Precision Psychiatry: Personalized Clinical Approach to Depression
Pages 245-261
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Risk Factors and Prevention Strategies for Depression in Childhood and Adolescence
Pages 263-278
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Neurobiology and Risk Factors of Late-Life Depression
Pages 279-295
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Gender Differences in Depression
Pages 297-307
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An Update on the Epidemiology of Major Depressive Disorder Across Cultures
Pages 309-315
