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Thrombolytic therapy is now reaching patients in a variety of settings all over the world. Formerly in the domain of sub-specialists, thrombolytic therapy now rests in the realm of emergency medicine, intensive care, vascular, and neurocritical physicians.
Extensively updated from previous editions, Thrombolytic Therapy for Acute Stroke, Third Edition is a practical and thorough reference to all those caring for acute stroke patients. Chapters feature new data, technologies and cases offering guidance to treating acute stroke patients – with or without thrombolytic therapy.
Physicians looking to utilize thrombolytic therapy for acute stroke will find this text an invaluable resource.
Table of Contents
1 The Ischemic Penumbra and Cell Survival ......................................... 1
Patrick D. Lyden
2 The March of Thrombolytic Therapy for Acute Ischemic
Stroke to Clinical Trials: Pre-clinical Thrombolysis
and Adjuncts to Thrombolysis Research ............................................. 27
Steven R. Levine , Syed Faraz Kazim , Pirouz Piran ,
and Frank C. Barone
3 Combination of Thrombolytic Therapy
with Antithrombotics and Neuroprotectants ........................................ 65
Andrew D. Barreto and James C. Grotta
4 Pilot and Preliminary Studies of Thrombolytic
Therapy for Stroke .................................................................................. 81
Steven R. Levine , E. Clarke Haley , and Patrick D. Lyden
5 Intravenous Thrombolytic Therapy for Acute Ischemic Stroke:
Results of Large, Randomized Clinical Trials ...................................... 95
Edward C. Jauch and Christine Holmstedt
6 Intra-arterial Thrombolysis in Acute Ischemic Stroke ....................... 113
Anthony J. Furlan , Randall Higashida , Irene Katzan ,
and Andrew Russman
7 Mechanical Revascularization with Embolectomy Devices ................ 135
Paula Eboli , Michael Schiraldi , and Michael J. Alexander
8 Combination of Intravenous t-PA and Endovascular Therapy ......... 149
Joseph P. Broderick and Blake A. Smith
9 Thrombolytic Therapy for Acute Stroke and the Test of Time .......... 165
Patrick D. Lyden
10 How to Run an Effective Code Stroke ................................................... 181
Jeffrey A. Switzer and Askiel Bruno
11 Telestroke: Delivery and Design ........................................................... 195
Konrad H. Schlick and Brett C. Meyer
12 The Impact of Neuroimaging on Acute Stroke Treatment:
Role of Computed Tomography............................................................. 227
Rüdiger von Kummer
13 The Impact of Neuroimaging on Acute Stroke Treatment:
Role of Magnetic Resonance Imaging ................................................... 251
Peter D. Schellinger and Martin Köhrmann
14 The rt-PA for Acute Stroke Protocol .................................................... 271
John Marler and Patrick D. Lyden
Afterword ......................................................................................................... 285
Illustrative Cases ............................................................................................. 287
Index ................................................................................................................. 347
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