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History of N-Acetylcysteine
Pages 3-15
Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable.
Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation.
The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.
History of N-Acetylcysteine
Pages 3-15
Neurotransmitter Systems: Glutamate
Pages 19-28
Neurotransmitter Systems: Dopamine
Pages 29-51
Oxidative Stress in Psychiatric Disorders
Pages 53-72
Mitochondrial Metabolism
Pages 73-103
Apoptosis
Pages 105-121
Inflammation
Pages 123-135
Clinical Trials on N-Acetylcysteine
Pages 139-146
N-Acetylcysteine in the Poisoned Patient
Pages 147-168
The Use of N-Acetylcysteine as a Chelator for Metal Toxicity
Pages 169-179
Application of N-Acetylcysteine in Neurological Disorders
Pages 181-202
Application of N-Acetylcysteine in Psychiatric Disorders
Pages 203-218
Clinical Treatment of Addictive Disorders with N-Acetylcysteine
Pages 219-233
The Clinical Use of N-Acetylcysteine for the Treatment and Protection Against Renal Disease
Pages 235-253
Application of N-Acetylcysteine in Pulmonary Disorders
Pages 255-276
The Clinical Use of N-Acetylcysteine in Cardiology
Pages 277-287
The Clinical Use of N-Acetylcysteine in Gastrointestinal Disorders
Pages 289-299
The Clinical Use of N-Acetylcysteine in Other Medical Disorders
Pages 301-330
The Physiological Effects of N-Acetylcysteine in Clinical Studies
Pages 331-348
Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease
Pages 349-386
Pharmacology, Formulations, and Adverse Effects
Pages 387-394
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