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Cardiac Transplantation and the Contribution of Pathology
Pages 3-10
This is the first book to focus entirely on the role of pathology in cardiac transplantation, linked to the clinical perspective through clinical–pathological correlation, multidisciplinary team working, and collaborative research. It provides a scientific framework with up-to-date pathological protocols and classification schemes and guides the reader through the chronological phases of the transplant process in a step-by-step approach. Topics include end-stage heart failure with pathologies encountered in the native heart, current issues surrounding donor selection, the multiple faces of rejection pathology correlated with clinical management and immunology, other post-transplant complications, details of pediatric and combined heart/other organ transplantation, and a useful practical appendix. Many high-quality images and illustrative cases are presented, along with learning points and ample references.
Transplantation medicine today is continuously changing as collaborative research into novel diagnostic techniques and immunosuppressive therapies translates into improved recipient management and survival. This book is aimed at practicing transplant pathologists and specialist trainees. It will also appeal to general pathologists and to physicians and surgeons involved in cardiac transplantation who need to understand the role of pathology in the clinical management of transplant recipients.
Cardiac Transplantation and the Contribution of Pathology
Pages 3-10
Advanced End-Stage Heart Failure: Epidemiology and Management
Pages 13-20
Mechanical Circulatory Support in End-Stage Heart Failure: Bridge to Transplantation and Destination Therapy
Pages 21-32
Clinical Indications for Heart Transplantation
Pages 33-40
Pathologies Encountered in Explanted Native Hearts
Pages 41-99
Pretransplant Endomyocardial Biopsy: When and Why
Pages 101-112
Donor Selection Criteria: Clinical and Pathological Insights
Pages 115-135
Donor Organ Harvesting and Preservation
Pages 137-145
Perioperative Myocardial Damage to the Graft
Pages 147-152
Graft Failure/Dysfunction: Clinical Issues and Role of Endomyocardial Biopsy
Pages 155-169
Clinical Management of Transplant Recipients
Pages 171-184
Practical Immunology for Pathologists
Pages 185-198
Pathology of Acute Cellular Rejection
Pages 199-217
Pathology of Antibody-Mediated Rejection
Pages 219-242
“Mixed” Rejection in Heart Transplantation
Pages 243-250
Pathological Non-rejection Findings in the Endomyocardial Biopsy
Pages 251-263
Noninvasive Tools for Monitoring Acute Cardiac Allograft Rejection: State of the Art
Pages 265-277
Cardiac Allograft Vasculopathy
Pages 279-305
Infections
Pages 309-327
Malignancies After Heart Transplantation
Pages 329-352
Chronic Kidney Disease After Heart Transplantation: Risk Factors, Clinics, and Histopathology
Pages 353-364
Pathology of Pediatric Heart Transplantation
Pages 367-377
Combined Heart Transplants
Pages 379-391
The Autopsy in Heart Transplantation
Pages 393-417
Examination of Native Hearts with Implantable Mechanical Circulatory Support Systems
Pages 419-425
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