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The fifth addition of this classic text that focuses on the diabetic foot continues the tradition of the previous four editions. More specifically, it includes contributions from a distinguished panel of clinicians and researchers, who have either participated in previous editions or are new, who provide up-to-date information on the pathophysiology and management of diabetic foot ulceration.
As with the previous editions, it is divided into three sections: the first part focuses on clinical features and diagnosis; the second on pathophysiology; and the third on the management of diabetic foot problems. The main emphasis of the clinical part is on the multidisciplinary approach that has been mainly developed by the world-renowned Joslin-Beth Israel Deaconess Foot Center, which pioneered the management of diabetic lower extremity problems. Also like previous editions, the author panel includes diabetologists, podiatrists, vascular surgeons, infectious disease specialists,orthotists, plastic and orthopedic surgeons, the majority of whom work at the Joslin-Beth Israel Deaconess Foot Center. In addition, the fifth edition not only describes the state-of-the-art current methods in clinical practice but also includes a thorough update of all research progress during the last five years.
This updated edition of this timely text will be of significant value to all physicians and researchers with interest in a comprehensive understanding of the diabetic foot.
Front Matter
Pages i-xv
Clinical Features and Diagnosis
Front Matter
Pages 1-1
The Epidemiology of Diabetic Foot Ulcer and Amputation
David J. Margolis
Pages 3-9
Clinical Examination and Risk Classification of the Diabetic Foot
Lawrence A. Lavery, Mehmet A. Suludere
Pages 11-25
Diabetic Neuropathy
Solomon Tesfaye, Triantafyllos Didangelos
Pages 27-46
Clinical Features and Diagnosis of Peripheral Arterial Disease
Nicholas J. Swerdlow, Allen D. Hamdan
Pages 47-58
Imaging of Infection in the Diabetic Foot
Mary G. Hochman, Caitlin Connolly
Pages 59-92
Principles of Care in the Diabetic Surgical Patient
Natasha Khazai, Osama Hamdy
Pages 93-106
Pathophysiology
Front Matter
Pages 107-107
Physiology and Pathophysiology of Wound Healing in Diabetes
Irena Pastar, Nathan C. Balukoff, Andrew P. Sawaya, Nicole M. Vecin, Marjana Tomic-Canic
Pages 109-134
Regeneration of the Skin and Peripheral Nerves in the Adult
Alan Z. Yang, Daniela Lee, Daniella Dennis, Samuel J. Lin
Pages 135-151
Neuropeptides, Inflammation, and Diabetic Wound Healing: Lessons from Experimental Models and Human Subjects
Lucas Mota, Frank W. LoGerfo, Aristidis Veves, Leena Pradhan-Nabzdyk
Pages 153-183
Pathophysiology of Microvascular Disease in Diabetes
Brandon J. Sumpio, Aristidis Veves
Pages 185-197
High Content Single Cell and Spatial Tissue Profiling Modalities for Deciphering the Pathogenesis and Treatment of Wound Healing
Yered H. Pita-Juarez, Nikolas Kalavros, Dimitra Karagkouni, Yuling Ma, Xanthi-Lida Katopodi, Ioannis S. Vlachos
Pages 199-218
Structural and Functional Changes in Skin of the Diabetic Foot
Paschalis Chatzipantelis, Eleftheria Angeliki Valsami, Antonios Kafanas, Aristidis Veves
Pages 219-231
Biomechanics of the Diabetic Foot: The Road to Foot Ulceration
Panagiotis V. Tsaklis, Nikolaos Tentolouris
Pages 233-252
Cell Therapies: New Frontier for the Management of Diabetic Foot Ulceration
Sasha Shenk, Ramone Brown, Olga Kashpur, Avi Smith, Ryan Imbriaco, Bradford Greaves et al.
Pages 253-271
Role of Extracellular Vesicles, Modified mRNA, miRNA, and siRNA in Diabetic Lower Extremity Complications
Georgios Theocharidis, Jenny Li
Pages 273-286
Tissue-Engineered Wound Dressings for Diabetic Foot Ulcers
Simon Matoori, Sahar Rahmani, David J. Mooney
Pages 287-298
Infection in Diabetes: Epidemiology, Immune Dysfunctions, and Therapeutics
Ruchi Roy, Raj Singh, Sasha H. Shafikhani
Pages 299-326
Biomarkers of Diabetic Foot Ulcers and Its Healing Progress
Monika A. Niewczas, Hetal Shah
Pages 327-338
Experimental Animal Models in Research: Diabetes and Impaired Wound Healing
Mauricio Contreras, Enya Wang
Pages 339-360
Management of the Diabetic Foot
Front Matter
Pages 361-361
Microbiology and Treatment of Diabetic Foot Infection
Mary T. LaSalvia, Adolf W. Karchmer
Pages 363-378
Preparation of the Wound Bed of the Diabetic Foot Ulcer
Kevin Riemer, Kevin Buczkowski
Pages 379-388
Topical Wound Care Treatment and Indications for Their Use
Abby Hargis, Narges Maskan Bermudez, Marita Yaghi, Robert S. Kirsner
Pages 389-403
Surgical Treatment of the Ulcerated Foot
Juan Ceja Solorio, John M. Giurini
Pages 405-431
Lower Extremity Arterial Reconstruction in Patients with Diabetes Mellitus: Principles of Treatment
Sophie X. Wang, Mark C. Wyers
Pages 433-455
Reconstruction of the Diabetic Foot
Eric Shiah, Amy Chen, Ryan P. Cauley, Arriyan S. Dowlatshahi
Pages 457-475
The Charcot Foot in Diabetes
Lee C. Rogers, Stephanie N. Campbell, Robert G. Frykberg
Pages 477-500
Amputations and Rehabilitation
John T. Marcoux, Thao Nguyen, Lars Stangenberg
Pages 501-523
Organization and Preventive Care
Front Matter
Pages 525-525
Organization of a Diabetic Foot Care Team
Thanh Dinh, Barry I. Rosenblum
Pages 527-534
Quality of Health Care
Katherine M. McDermott, Caitlin W. Hicks
Pages 535-549
Psychosocial and Educational Implications of Diabetic Foot Complications
Elizabeth A. Beverly, Arlene Smaldone
Pages 551-564
The Role of Footwear in the Prevention of Diabetic Foot Problems
Luigi Uccioli, Laura Giurato
Pages 565-578
Back Matter
Pages 579-592
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