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Neuroendocrine Changes of the Menopausal Transition
Pages 1-7
This book analyzes the effects of estrogens and progesterone on brain cells, the immune system, neuro inflammation, myelin formation and steroid receptor distribution, as well as their clinical impacts.
It also explores the relationship between sex-steroid withdrawal and the development of brain symptoms such as hot flushes, sleep disorders, mood changes, depression and also cognitive disorders and dementia, as well as the effects of hormone menopause therapy on such symptoms and diseases.
Starting with obstetrical history and cardiovascular risk in later life, the second part of the book examines the effects of estrogens and progestogens on vascular tissues, atherosclerosis and coronary heart diseases, as well as the impact of hormone replacement therapies on cardiovascular risks and mortality.
This volume is a useful, clear and up-to-date tool for gynecologists, endocrinologists, neurologists and cardiologists, and serves as a valuable source of information for all physicians involved in women’s health.
Neuroendocrine Changes of the Menopausal Transition
Pages 1-7
The Neurological and Immunological Transitions of the Perimenopause: Implications for Postmenopausal Neurodegenerative Disease
Pages 9-25
Estrogenic Regulation of Neuroprotective and Neuroinflammatory Mechanisms: Implications for Depression and Cognition
Pages 27-41
Estetrol and Its Effects on the Damaged Brain
Pages 43-91
Adrenal Androgens Impact on Neurosteroids
Pages 93-99
Do Menopausal Symptoms Account for the Declines in Cognitive Function During the Menopausal Transition?
Pages 101-109
Allopregnanolone as a Therapeutic to Regenerate the Degenerated Brain
Pages 111-123
Reproductive Depression and the Response to Hormone Therapy
Pages 125-133
Sex, Gender, and the Decline of Dementia
Pages 135-148
Obstetric History and Cardiovascular Disease (CVD) Risk
Pages 149-160
HRT and Cardiovascular Disease
Pages 161-167
Unique Vascular Benefits of Estetrol, a Native Fetal Estrogen with Specific Actions in Tissues (NEST)
Pages 169-195
Vascular Effects of Progestogens
Pages 197-207
Sex Differences, Progesterone, and Ischemic Stroke
Pages 209-231
Atherogenesis: Estrogen Induction of Polysialylated nCAM (PSA-nCAM) Blocks Monocyte Capture by Vascular Endothelial Cells
Pages 233-244
Cardiovascular Risk in Climacteric Women: When to Begin the Hormone Treatment?
Pages 245-255
HRT for the Primary Prevention of Coronary Heart Disease
Pages 257-264
Symptoms and Hormones: Fine-Tuning Atherosclerotic Risk?
Pages 265-269
Cardiovascular Mortality Risk and HRT
Pages 271-274
HT: Pharmacology Tailored to Women’s Health
Pages 275-285
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