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The Development of PGD
Pages 1-4
Intended for readers with a background in fertility medicine as well as those less familiar with IVF, this comprehensive work presents an update on preimplantation genetic testing to enable single embryo transfer (SET). An international cast of contributors explains the treatment sequence—from ovulation induction to luteal support—aiming to transfer only one euploid embryo. Applications of molecular techniques for gamete and embryo assessment are fully detailed, with a focus on the strengths and limitations of each. In addition, expert commentary is shared across a range of regulatory challenges associated with embryo screening and cryopreservation. As access to advanced reproductive technology increases against a sharper background of healthcare reform, clinicians, economists, bioethicists and legislators alike will find this new volume relevant and highly accessible.
The Development of PGD
Pages 1-4
Elements of Informed Consent for Preimplantation Genetic Diagnosis
Pages 5-19
Controlled Ovarian Stimulation for Follicular Recruitment and Oocyte Recovery in IVF
Pages 21-31
Biomarker-Based Flow Cytometric Semen Analysis for Male Infertility Diagnostics and Clinical Decision Making in ART
Pages 33-51
Comparison of Methods for Assessment of Sperm DNA Damage (Fragmentation) and Implications for the Assisted Reproductive Technologies
Pages 53-71
Single Gamete Insemination Aiming at the Ideal Conceptus
Pages 73-88
Comprehensive Chromosomal Screening from Polar Body Biopsy to Blastocyst Trophectoderm Sampling: Evidences and Considerations
Pages 89-102
Polar Body Diagnosis (PBD): An Alternative and Supplement to Preimplantation Diagnosis for Single Embryo Transfer
Pages 103-121
Efficiency of Polar Body Biopsy on Aneuploidy Screening by DNA Microarray for Single Euploid Embryo Transfer
Pages 123-131
Prediction of Embryo Viability by Morphokinetic Evaluation to Facilitate Single Transfer
Pages 133-145
Utilisation of Transcriptome-Based Biomarkers for Single Embryo Transfer
Pages 147-161
Array CGH and Partial Genome Sequencing for Rapidly Karyotyping IVF Blastocysts Before Single Transfer
Pages 163-178
Current and Future Preimplantation Genetic Screening (PGS) Technology: From Arrays to Next-Generation Sequencing
Pages 179-191
SNP Array, qPCR, and Next-Generation Sequencing-Based Comprehensive Chromosome Screening
Pages 193-202
Expanding PGD Applications to Nontraditional Genetic and Non-genetic Conditions
Pages 203-215
Should Molecular Cytogenetic Techniques Be Applied to Facilitate Single Embryo Transfer in Egg Donation Cases? Assessment of Frequency and Distribution of Embryo Aneuploidy After Anonymous Donor Oocyte IVF
Pages 217-229
Selecting the Right Embryo in Mitochondrial Disorders
Pages 231-246
Single Embryo Transfer: Significance of the Embryo Transfer Technique
Pages 247-262
The Vitrification Component: An Integral Part of a Successful Single-Embryo Transfer Program
Pages 263-272
A Review of Luteal Support Protocols for Single Embryo Transfers: Fresh and Frozen
Pages 273-293
Cost-Effectiveness of Single Embryo Transfers Relative to Higher Embryo Transfer Policies in Clinical Practice: A Population-Based Analysis
Pages 295-314
The Quebec Experience—One Plus One Equals Two at Once: Presenting Cumulative Pregnancy Rates as the Ideal Outcome in Elective SET Programmes
Pages 315-321
Regulatory Aspects of Embryo Transfer: An Israeli View
Pages 323-326
Single Embryo Transfer: The Québec Experience
Pages 327-338
Regulatory Aspects of Embryo Testing: An American View
Pages 339-351
The Ethical and Legal Analysis of Embryo Preimplantation Testing Policies in Europe
Pages 353-366
Preimplantation Genetic Screening for the Single Embryo: Aims and Responsibilities
Pages 367-376
Crossing the Rubicon: Assisted Reproductive Technologies and Remaining Human
Pages 377-393
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