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This book provides readers with the most up-to-date practical information on breast cancer screening. Since breast cancers are highly heterogeneous, time to clinical onset from the initial carcinogenesis differs diversely between cancers. Pathological germline variants and driver mutations cause a high lifetime risk of breast cancer. The lifetime risks are various according to what genes are pathologically dysfunctional. Integrated omics and imaging technologies have established varying tumour characteristics. Thus, this book suggests that a more individualised scheme is required to improve breast cancer screening.
A key aim is to demonstrate how multiple diagnostic imaging modalities such as mammography, ultrasonography, MRI, PET and dbPET improve breast cancer screening accuracy. Mammography screening alone may have a limited impact on breast cancer risk prediction. These issues are crucial to discuss. Clinical experts recommend that new modalities be incorporated for women with dense breasts, like ultrasonography, dynamic mammography, MRI and maybe breast-dedicated PET. Topics on these modalities are going to be summarized in this book. An in-depth review of these modalities is summarised in this book. In addition, new diagnostic modalities, including risk assessment tools, multi-cancer early detection tests using liquid biopsy, the role of protein biomarkers in breast cancer risk screening, challenges, and hopes for future advances, are also covered in this book.
Front Matter
Pages i-xii
PDF
Advances in Breast Cancer Screening: Precision, Imaging, and Harms
Masakazu Toi, Masako Kataoka, Ravi Velaga, John R. Benson, Masahiro Takada, Ismail Jatoi
Pages 1-27
Breast Cancer Risk Assessment Models and Multi-Cancer Early Detection Tests
Masakazu Toi, Masako Kataoka, Ravi Velaga, John R. Benson, Yoshiaki Matsumoto
Pages 29-43
Hereditary Breast Cancer and Pathogenic Germline Variants
Ravi Velaga, Masakazu Toi, Nobuko Kawaguchi-Sakita, John R. Benson, Noriko Senda
Pages 45-59
Over-Diagnosis and Breast Cancer Screening
John R. Benson, Eric Jou, Ismail Jatoi
Pages 61-75
Breast Cancer Screening with MRI in Women with Over 20% Lifetime Risk
Madeleine M. A. Tilanus-Linthorst, Emiel J. T. Rutgers
Pages 77-83
MRI for Breast Cancer Screening: Technical Consideration
Masako Kataoka
Pages 85-95
Risk-Reducing Surgery for Breast Cancer
John R. Benson, Samantha Muktar, Ismail Jatoi
Pages 97-111
Cost-Effectiveness of Genetic Testing Strategies for Breast Cancer
Samuel Oxley, Xia Wei, Michail Sideris, Ranjit Manchanda
Pages 113-126
Biomarkers in Proteomics
Dong-Young Noh, Myeong-Hee Yu, Yumi Kim, Tae Yoon Oh
Pages 127-142
Ultrasound in Breast Cancer Screening
Narumi Harada-Shoji, Takanori Ishida, Akihiko Suzuki, Noriaki Ohuchi
Pages 143-149
Detection of Breast Cancer by PET
Kanae K. Miyake
Pages 151-162
Inverse Scattering Problem and Microwave Mammography
Kenjiro Kimura, Ayaka Hirai, Kai Yabumoto, Akari Inagaki, Yoshiharu Nakashima, Takayoshi Yumii et al.
Pages 163-175
Photoacoustic Imaging of Breast Cancer
Yoshiaki Matsumoto, Masakazu Toi
Pages 177-186
Japanese Breast Cancer Screening: Challenges and Hopes
Masako Kataoka
Pages 187-189
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