Titolo: Raynaud’s Phenomenon 2nd edition

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Raynaud’s Phenomenon 2nd edition

From Pathogenesis to Management

Editore

Springer

Anno

2024

Pagine

443

ISBN

9783031525803

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This book comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists. Raynaud’s phenomenon is an inappropriate and exaggerated response of the digital and cutaneous circulation to cold environmental temperatures. It is common, often causing significant morbidity and it is a major challenge for physicians at every level and specialty. A comprehensive review of Raynaud’s is now timely because of the incredible progress in understanding the molecular mechanisms of the normal regulation of cutaneous blood flow and how disease can disrupt the function of these specialized vessels. Likewise, the clinical implications of Raynaud’s phenomenon are better appreciated with studies defining its prevalence, the associated diseases, and new treatment approaches for patients suffering from it. The nomenclature used to classify cases has changed over the years and is important to understand these terms both for clinical care andresearch.

This fully updated second edition comprehensively discusses various causes of Raynaud’s phenomenon including childhood Raynaud’s phenomenon, Raynaud’s phenomenon secondary to connective tissue disease, occupational causes, and a variety of other associated disorders. Careful consideration is given to the diagnosis of Raynaud’s phenomenon with state of the art discussion of nailfold capillary examination, non-invasive imaging, angiography, and appropriate serological testing. The concept that Raynaud’s phenomenon is associated with systemic disease or can be the manifestation of a systemic vasospastic disorder is also presented. In addition to reviewing both non-drug and drug therapy for patients with Raynaud’s phenomenon, this volume provides a practical approach in specific clinical situations by presenting problematic cases and the authors’ expert opinions on therapy. It also discusses mechanisms contributing to the vascular dysfunctionof primary Raynaud’s phenomenon and the vascular disease of secondary Raynaud’s phenomenon.

Engaging readers with case vignettes and a plethora of visual aids, Raynaud’s Phenomenon: From Pathogenesis to Management is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to adult and pediatric physicians, rheumatologists, and clinical and basic researchers.

    Front Matter
    Pages i-xvii
    Download chapter PDF
    Historical Perspective of Raynaud’s Phenomenon
        Andrea Fava, Francesco Boin
    Pages 1-13
    Definition, Nomenclature, and Diagnostic Criteria
        John D. Pauling, Marco Matucci-Cerinic
    Pages 15-23
    Epidemiology of Raynaud’s Phenomenon
        Kimti Kumar, Adam Maundrell, Susanna M. Proudman
    Pages 25-40
    The Normal Structure and Function of the Cutaneous Vascular System
        Nicholas A. Flavahan
    Pages 41-59
    A Mechanistic Approach to Understanding and Preventing the Vasculopathy of Raynaud’s Phenomenon
        Nicholas A. Flavahan
    Pages 61-84
    Practical Approach to the Patient with Raynaud’s Phenomenon: Primary Versus Secondary Raynaud’s Phenomenon
        Ariane L. Herrick
    Pages 85-99
    Raynaud’s Phenomenon in the Pediatric Age
        Francesco Zulian, Clare Pain
    Pages 101-115
    Secondary Raynaud’s Phenomenon: Focus on Rheumatic Diseases
        Voon H. Ong, Christopher P. Denton
    Pages 117-140
    Other Secondary Causes
        Michael Hughes, Ami A. Shah
    Pages 141-167
    Raynaud’s Mimics
        Robyn T. Domsic, Julie J. Paik
    Pages 169-192
    Systemic Vasospasm
        Laura K. Hummers
    Pages 193-206
    Nailfold Capillaroscopy
        Vanessa Smith, Elvis Hysa, Francesca Ingegnoli, Maurizio Cutolo
    Pages 207-224
    Autoantibodies in Raynaud’s Phenomenon
        Victoria Flower
    Pages 225-244
    Angiography
        Thomas Reifsnyder
    Pages 245-253
    Laboratory Assessment of Raynaud’s Phenomenon
        Andrea Murray
    Pages 255-295
    Statistical Design and Reporting of Randomised Controlled Trials for Raynaud’s Phenomenon
        Jack Wilkinson, James R. Seibold
    Pages 297-307
    Clinical Outcome Measures in Raynaud’s Phenomenon
        John D. Pauling, Dinesh Khanna
    Pages 309-324
    Non-drug Approaches to Treating Raynaud’s Phenomenon
        Linda Kwakkenbos, Elsa-Lynn Nassar, Nadine Sigmans, Brett D. Thombs
    Pages 325-341
    Drug Therapy
        Ariane L. Herrick, Fredrick M. Wigley, Janet Pope
    Pages 343-368