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This book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy.
Pages i-xiii
Pages 1-1
Nuclear Medicine Imaging Tracers for Neurology
Philip H. Elsinga
Pages 3-35
Adriaan A. Lammertsma
Pages 37-52
Hiroshi Matsuda
Pages 53-72
Sanne K. Meles, Jelmer G. Kok, Remco J. Renken, Klaus L. Leenders
Pages 73-104
Artificial Intelligence in the Analysis of PET Scans of the Human Brain
Kim Mouridsen, Ronald Borra
Pages 105-117
Georg Schramm, Koen Van Laere, Peter Jan Van Laar, Michel Koole
Pages 119-163
The Default Network of the Brain
Koene R. A. Van Dijk, Alexander Drzezga
Pages 165-179
Use of Nuclear Medicine Molecular Neuroimaging to Model Brain Molecular Connectivity
Carlos A. Sanchez-Catasus, Martijn L. T. M. Müller, Peter Paul De Deyn, Rudi A. J. O. Dierckx, Nicolaas I. Bohnen, Lester Melie-Garcia
Pages 181-207
Pages 209-209
PET Neuroimaging in Dementia Conditions
Daniela Perani, Silvia Paola Caminiti, Giulia Carli, Giacomo Tondo
Pages 211-282
Aβ Imaging in Aging, Alzheimer’s Disease, and Other Neurodegenerative Conditions
Victor L. Villemagne, Vincent Doré, Samantha Burnham, Christopher C. Rowe
Pages 283-343
PET Imaging of the α4β2* Nicotinic Acetylcholine Receptors in Alzheimer’s Disease
Osama Sabri, Philipp M. Meyer, Hermann-Josef Gertz, Solveig Tiepolt, Peter Brust, Henryk Barthel et al.
Pages 345-365
Neuroimaging Findings in Mild Cognitive Impairment
Federico Massa, Matteo Bauckneht, Enrico Peira, Caterina Lapucci, Agnese Picco, Selene Capitanio et al.
Pages 367-425
Impact of the New Conceptual Framework of Alzheimer’s Disease in Imaging Studies
Bruno Dubois, Nicolas Villain, Claudia Jacova, Olga Uspenskaya
Pages 427-451
Ronald W. J. van Rheenen, Gilles N. Stormezand, Jacoba P. van Amerongen, Andreas Otte, Peter Paul De Deyn, Rudi A. J. O. Dierckx
Pages 453-468
Nuclear Imaging in Frontotemporal Dementia
Fransje E. Reesink, Gilles N. Stormezand, Rudi A. J. O. Dierckx, Peter Paul De Deyn
Pages 469-490
Parkinsonian Dementias: PET Findings
Prabesh Kanel, Martijn L. T. M. Müller, Nicolaas I. Bohnen
Pages 491-513
SPECT/PET Findings in Dementia with Lewy Bodies
Sedigheh Zabihi, Tim Whitfield, Zuzana Walker
Pages 515-561
SPECT and PET in Vascular Dementia
Yumin Zheng, Zhi Zhou
Pages 563-575
Value of MIBG in the Differential Diagnosis of Neurodegenerative Disorders
Mitsuhiro Yoshita
Pages 577-590
Pages 591-591
Perfusion Imaging in Healthy Human Aging
Sabine L. Collette, Auke P. Appelman, Reinoud P. H. Bokkers
Pages 593-606
Carotid Plaque Imaging with SPECT/CT and PET/CT
Riemer H. J. A. Slart, Hendrikus H. Boersma, Clark J. Zeebregts
Pages 607-627
PET in Brain Arteriovenous Malformations and Cerebral Proliferative Angiopathy
J. Marc C. van Dijk, Timo Krings, Janine Doorduin, Riemer H. J. A. Slart
Pages 629-650
PET Reveals Pathophysiology in Ischemic Stroke
Wolf-Dieter Heiss, Olivier Zaro-Weber
Pages 651-671
Pages 673-673
Michele Matarazzo, Andre C. Felicio, A. Jon Stoessl
Pages 675-708
Computer-Aided Diagnosis of Parkinson’s Disease, Based on SPECT Scans of the Dopamine Transporter
Francisco P. M. Oliveira, Durval C. Costa
Pages 709-727
PET and SPECT Imaging in Atypical Parkinsonian Syndromes
Martin Niethammer, Yoon Young Choi, Chris C. Tang, David Eidelberg
Pages 729-757
Martin R. Turner, Marco Pagani
Pages 759-781
H. P. H. (Berry) Kremer
Pages 783-798
PET and SPECT Imaging in Dystonia
Evelien Zoons, Jan Booij, Bauke de Jong, Marina A. J. Tijssen
Pages 799-820
PET and SPECT Imaging in Hyperkinetic Movement Disorders
Evelien Zoons, Sarvi Sharifi, Jan Booij, Bauke de Jong, Marina A. J. Tijssen
Pages 821-848
Clinical Applications of [123I]FP-CIT SPECT Imaging
Jan Booij, Marina A. J. Tijssen, Henk W. Berendse
Pages 849-870
Pages 871-871
Hans Christiaan Klein, Lot de Witte, Robert Bransfield, Peter Paul De Deyn
Pages 873-892
PET Imaging in Multiple Sclerosis
Chris W. J. van der Weijden, Jan F. Meilof, Erik F. J. de Vries
Pages 893-916
PET and SPECT Imaging of Neurotoxicity
Erik F. J. de Vries, Rudi A. J. O. Dierckx, Didima M. G. de Groot
Pages 917-946
PET and SPECT in Hepatic and Uraemic Encephalopathy
Georg Berding, Frank Bengel, Karin Weissenborn
Pages 947-965
Pages 967-967
Matthias Koepp, Marian Galovic, Maria Ilyas-Feldmann
Pages 969-982
Imaging Evaluation of Epilepsy: Functional and Structural Approaches
Sara K. Inati, William H. Theodore
Pages 983-1005
SISCOM (Subtraction Ictal SPECT with Coregistration to MRI)
Hwareung Lee, Jung Sik Kim, Ji Hyun Kim, Seung Bong Hong
Pages 1007-1023
Pages 1025-1025
Karl Herholz
Pages 1027-1049
Single-Photon Emission Computed Tomography [Neuro-SPECT] Imaging of Brain Tumors
George A. Alexiou, Spyridon Tsiouris, Andreas D. Fotopoulos
Pages 1051-1065
Bart R. J. van Dijken, Roelien H. Enting, Hanne-Rinck Jeltema, Miranda C. A. Kramer, Rudi A. J. O. Dierckx, Anouk van der Hoorn
Pages 1067-1081
Imaging Brain Metastases of Neuroendocrine Tumors
Klaas Pieter Koopmans, A. H. Brouwers
Pages 1083-1093
Traumatic Brain Injury: Nuclear Medicine Neuroimaging
Carlos A. Sanchez-Catasus, Gilles N. Stormezand, David Vállez García, Eloísa Le Riverend Morales, Reinaldo Galvizu Sánchez, Rudi A. J. O. Dierckx
Pages 1095-1120
Pages 1121-1121
Anaesthesia and PET of the Brain
Anthony Absalom, Ram Adapa
Pages 1123-1148
PET Imaging in Altered States of Consciousness: Coma, Sleep, and Hypnosis
Estelle A. C. Bonin, Géraldine Martens, Helena Cassol, Camille Chatelle, Steven Laureys, Aurore Thibaut
Pages 1149-1176
Modulation of CNS Functions by Deep Brain Stimulation: Insights Provided by Molecular Imaging
Alexandre Boutet, Mehr Jain, Dave Gwun, Pablo Rusjan, Clemens Neudorfer, Gavin J. B. Elias et al.
Pages 1177-1244
Radionuclide Imaging Studies in Pediatric Neurology
Ajay Kumar, Csaba Juhasz, Harry T. Chugani
Pages 1245-1289
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