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This book summarizes the broad and rapidly evolving field of geriatric pharmacotherapy, which is becoming increasingly relevant for practicing physicians who care and prescribe medications for older patients. Around the globe, ageing populations are associated with an increased prevalence of chronic diseases. Older adults are often affected by multimorbidity, i.e., suffer from more than one chronic disease. The main consequence of multimorbidity is polypharmacy, which is commonly defined as the regular use of five or more medicines. Polypharmacy has now reached epidemic proportions in our societies, and is associated with an increased risk of drug-drug interactions, drug-disease interactions and adverse drug reactions. The management of polypharmacy in older patients with complex multimorbidity poses several challenges and needs to be based on specific knowledge and prescribing expertise.
The aim of this book is to provide a comprehensive update on the field, and to share the expertise needed to optimize the management of pharmacotherapy in older patients.
Pages i-ix
Front Matter
Pages 1-1
The Impact of Ageing on Pharmacokinetics
Pages 3-14
Polypharmacy: Definition, Epidemiology, Consequences and Solutions
Pages 15-31
Drug–Drug and Drug–Nutrients Interactions: From Theory to Clinical Relevance
Pages 33-46
Inappropriate Prescription of Medicines
Pages 47-58
Pages 59-68
Adverse Drug Reactions in Older People: A Twenty-First Century View
Pages 69-80
Adherence: How to Measure and Improve It
Pages 81-90
Medication Reconciliation and Review: Theory, Practice and Evidence
Pages 91-104
The Role of Pharmacists in Optimising Drug Therapy
Pages 105-117
Deprescribing: Evidence Base and Implementation
Pages 119-128
Front Matter
Pages 129-129
General Principles of Management of Patients with Multimorbidity and Frailty
Pages 131-142
Pages 143-159
Pages 161-172
Optimizing Pharmacotherapy in Older Patients: Delirium
Pages 173-183
Optimizing Pharmacotherapy in Older Adults: Urinary Incontinence
Pages 185-198
Pages 199-215
Pages 217-227
Pages 229-237
Pages 239-267
Pharmacological Treatment of Cognitive and Behavioral Disorders in Dementia
Pages 269-287
Pharmacological Treatment of Osteoporosis in Older Patients
Pages 289-309
Chronic Respiratory Disease: COPD, IPF
Pages 311-330
Pages 331-347
Stroke Therapeutics in the Care of Older Persons
Pages 349-367
Optimizing Pharmacotherapy in Older Patients with Depression or Anxiety
Pages 369-379
Nutritional Deficiency and Malnutrition
Pages 381-389
Pharmacotherapy of Insomnia in Older Adults
Pages 391-404
Optimizing Pharmacotherapy in Older Patients: An Interdisciplinary Approach: Chronic Kidney Disease
Pages 405-426
Pages 427-440
Pages 441-445
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