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This new edition provides a fully updated guide to obesity’s relation to lung disease. Over forty percent of the U.S. population is obese, and obesity is increasing in much of the world. Obesity has a major impact on health conditions such as diabetes and cardiovascular disease. The effects of obesity on lung disease have drawn increasing attention in recent years. Furthermore, the COVID pandemic has dramatically illustrated how obesity affects respiratory disease, constitutes a major risk factor for COVID-19, and presents challenges to pulmonary care in the ICU.
Obesity changes physiology, immune and metabolic function, and is associated with changes in diet and the microbiome, all of which combine to have a major impact on the pathogenesis of respiratory diseases. Obesity is thus a risk factor for many respiratory diseases such as asthma, pulmonary hypertension, thromboembolic disease, obstructive sleep apnea and ARDS. Obesity also complicates the management of manyother respiratory diseases and conditions such as COPD, thromboembolic disease, and the care of the critically ill patient.
The objectives of this book are three-fold:
There have been major advances in our understanding of the relationship between obesity and lung disease since the first edition in 2013, in addition to the major lessons learned about the importance of obesity during the COVID-19 pandemic. This has led to the addition of eight new chapters on topics such as, the microbiome, lung transplant, and COVID-19 in the ICU.
This is an ideal guide for all clinicians taking care of patients with pulmonary and critical care diseases, as well as basic and translational scientists interested in how obesity affects respiratory health.
Front Matter
Pages i-ix
Effects of Obesity on Lung Function
Gregory G. King
Pages 1-19
Obesity-Mediated Alterations in Immune Function, Host Defense, and Lung Disease
Anna Reichenbach, Silvia Cabrera Guerrero, Deepa Rastogi
Pages 21-42
Obesity, the Microbiome, and Lung Disease
Jennifer L. Ingram, Yvonne J. Huang
Pages 43-71
Genetics and Genomics of Obesity and Lung Diseases
Erick Forno
Pages 73-82
The Western Dietary Pattern and Respiratory Health
Bronwyn S. Berthon, Lily M. Williams, Hayley A. Scott, Evan J. Williams, Lisa G. Wood
Pages 83-124
Pathogenesis of Obstructive Sleep Apnea in Obesity
Susheel P. Patil, Jason Paul Kirkness
Pages 125-150
Obesity Hypoventilation Syndrome
Alejandra C. Lastra, Nancy Stewart, Babak Mokhlesi
Pages 151-180
Obesity and Asthma: Epidemiology and Clinical Presentation
Jessica Reyes-Angel, Erick Forno
Pages 181-199
Obesity and Asthma: Metabolic Dysregulation
Fernando Holguin
Pages 201-210
Obesity and Asthma: Endotypes and Mechanisms
Arjun Mohan, Muhammad Adrish, Njira L. Lugogo
Pages 211-227
Asthma Management in Obesity
Anne E. Dixon, Sharmilee M. Nyenhuis
Pages 229-248
Obesity and Chronic Obstructive Pulmonary Disease (COPD)
Frits M. E. Franssen
Pages 249-265
Obesity, Metabolic Syndrome, and Pulmonary Hypertension
Jessica B. Badlam
Pages 267-287
Association of Obesity and Thromboembolic Disease
Margarita Kushnir, Henny Billett
Pages 289-300
Obesity and Respiratory Infections Including COVID-19
Peter Mancuso
Pages 301-320
Obesity and Lung Health in Children
Jason E. Lang, Dharini Bhammar
Pages 321-345
Obesity and Acute Respiratory Distress Syndrome
William G. Tharp, Renee D. Stapleton
Pages 347-364
Obesity and Mechanical Ventilation
Lorenzo Berra, Luigi G. Grassi
Pages 365-385
Obesity and COVID-19 in the Intensive Care Unit
MaryEllen Antkowiak
Pages 387-402
Pages 403-411
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