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This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.
Front Matter
Pages i-xxi
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Overview of CNS Development and Disorders
Front Matter
Pages 1-1
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Overview of CNS Organization and Development
Richard E. Brown
Pages 3-28
Neural Induction and Regionalization
Jeffrey T. Wigle, David D. Eisenstat
Pages 29-38
Neural Stem Cells, Differentiation, and Migration
Jessica M. Livingston, Emily A. B. Gilbert, Donna Gao, Cindi M. Morshead
Pages 39-54
Neurotrophins and Cell Death
Arman Shekari, Crystal Mahadeo, Nisha Sanwalka, Margaret Fahnestock
Pages 55-75
Synaptogenesis
Margaret H. Hastings, James Gilbert, Yuda Huo, Heng-Ye Man
Pages 77-92
Axonal Guidance
Mikaela Nevin, Janine Gallego, David D. Eisenstat
Pages 93-106
Myelination
Janine Gallego, Mikaela Nevin, David D. Eisenstat
Pages 107-121
Epigenetics
Helena Biasibetti-Brendler, Michael Steffen Kobor
Pages 123-145
The Impact of an Adverse Intrauterine Environment on Neurodevelopment
Sindhu Ramachandra, Michelle Low, Nethra Madurai, Maide Ozen, Yuma Kitase, Shenandoah Robinson et al.
Pages 147-163
Stress as a Determinant of Neurodevelopmental Outcomes
Bona Kim, Stephen G. Matthews
Pages 165-178
Sex Differences in Neurodevelopment and Its Disorders
Richard E. Brown
Pages 179-212
Autism Spectrum Disorders
Front Matter
Pages 213-213
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The History of Autism Spectrum Disorder
Alexandra Jackman, Lonnie Zwaigenbaum
Pages 215-226
Epidemiology
Mayada Elsabbagh
Pages 227-241
An Approach to the Diagnosis of Autism Spectrum
Cecilia Lee, Melanie Penner
Pages 243-251
Autism Spectrum Disorder: Cognition
Elizabeth Kelley, Alison Dodwell
Pages 253-268
The Neuroradiology of Autism: Framing Neuroimaging Investigations of the Autistic Brain Based on the US NIMH Research Domain Criteria
Hsiang-Yuan Lin, Meng-Chuan Lai
Pages 269-282
Neuropathology of Autism
Yarden Kezerle
Pages 283-291
Autism Spectrum Disorders
Genetics and Epigenetics of ASD
Bahareh A. Mojarad, Farah Qaiser, Ryan K. C. Yuen
Pages 293-307
Preclinical Models of Autism Spectrum Disorder
Stephania Assimopoulos, Antoine Beauchamp, Jason P. Lerch
Pages 309-325
Biomedical Interventions for Autism Spectrum Disorder
Janys Joy Lim, Evdokia Anagnostou
Pages 327-335
Interventions in ASD: Psychosocial Interventions and Supports for ASD
Jessica A. Brian, Isabel M. Smith, Katherine Stover
Pages 337-350
Fetal Alcohol Spectrum Disorder
Front Matter
Pages 351-351
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Clinical Perspectives on the Diagnostic Assessment of Individuals with FASD
Ana C. Hanlon-Dearman, Sally Longstaffe
Pages 353-369
Epidemiology of Alcohol Consumption among Pregnant and Childbearing Age Women and Fetal Alcohol Spectrum Disorder
Svetlana Popova, Jürgen Rehm, Kevin Shield
Pages 371-378
Fetal Alcohol Spectrum Disorder: Diagnosis
Jocelynn L. Cook, Courtney R. Green
Pages 379-395
Magnetic Resonance Imaging in Fetal Alcohol Spectrum Disorder (FASD)
Catherine Lebel, Ashley Ware
Pages 397-407
Neuropathological Changes in Humans with History of Prenatal Alcohol Exposure or Diagnosis of Fetal Alcohol Spectrum Disorder
Marc R. Del Bigio
Pages 409-423
Genetics and Epigenetics of FASD
Jessica A. Baker, Shuliang Yu, Matthew T. Scott, Kristin M. Hamre
Pages 425-439
Genetic, Epigenetic, and Environmental Influences on Fetal Alcohol Spectrum Disorder: Implications for Diagnosis, Research and Clinical Practice
Alexandre A. Lussier, Berardino Petrelli, Geoffrey G. Hicks, Joanne Weinberg
Pages 441-456
Fetal Alcohol Spectrum Disorder: Interventions
Jacqueline Pei, Aamena Kapasi, Carmen Rasmussen
Pages 457-465
Cerebral Palsy
Front Matter
Pages 467-467
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Cerebral Palsy: Clinical Vignettes
Michael Shevell
Pages 469-477
Cerebral Palsy: Epidemiology
Shona Goldsmith, Sarah McIntyre, Eve Blair, Hayley Smithers-Sheedy, Nadia Badawi, Michele Hansen
Pages 479-495
Diagnosis of Cerebral Palsy
Young-Min Kim, Stephen Ashwal
Pages 497-513
Neuroradiology of Cerebral Palsy
Fatema Al Amrani, Christine Saint-Martin, Pia Wintermark
Pages 515-532
Neuropathology of Cerebral Palsy
Harvey B. Sarnat
Pages 533-546
Genetics and Genomics of Cerebral Palsy
Jan Friedman, Clara van Karnebeek
Pages 547-568
Pre-Clinical Models of Cerebral Palsy
Zeenat Ladak, Jerome Y. Yager
Pages 569-578
Therapeutic Approaches for the Treatment of Cerebral Palsy and Developmental Disability
Michael G. Fehlings, Stephanie R. Beldick, Janette Mailo, Oriana Shaw, Sarah Almas, Jerome Y. Yager
Pages 579-609
Co-Morbidities in Neurodevelopmental Disorders
Front Matter
Pages 611-611
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Sleep Disorders
Gabrielle Rigney, Pratima Gulati, Penny Corkum, Shelly K. Weiss
Pages 613-629
Optimizing Therapy of Seizures in Children and Adolescents with Developmental Disabilities
Anthony Fine, Elaine Wirrell, Katherine Nickels
Pages 631-653
Behavioral and Mental Health Disorders (Including Attentional Disorders)
I. Leslie Rubin, Claire D. Coles, Jarrett Barnhill
Pages 655-674
Role of Gender and Neurodevelopmental Disabilities
Donald E. Greydanus, Dilip R. Patel, Joav Merrick
Pages 675-683
A Non-Categorical Approach to Childhood Neurodisability: Concepts, Evidence, and Implications for Clinical Practice, Organization of Services, Teaching, and Research
Anton R. Miller, Emily Gardiner, Peter L. Rosenbaum
Pages 685-695
Pain and Symptom Management in Neurodevelopmental Disorders: Sensory and Nociceptive Function/Pain and Symptom Management
Chantel Burkitt, Lara Genik, Alyssa Merbler, Hal Siden, Tim F. Oberlander, Frank Symons
Pages 697-711
Pharmacology, Psychopharmacology, and Adverse Drug Reactions
Jarrett Barnhill, Roberto A. Blanco, Kateland Napier, Takahiro Soda
Pages 713-729
Developmental Origins, Differential Susceptibility, and Resilience in Neurodevelopmental Disorders
Marina White, Marie-Elyse Lafaille-Magnan, Christopher Roche, Alexia Jolicoeur-Martineau, Ashley Wazana, Kristin L. Connor
Pages 731-749
Neurodevelopmental Disorders in the Context of Families
Front Matter
Pages 751-751
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Children with Neurodevelopmental Disabilities and the Right to Health
Keiko Shikako, Jonathan K. Y. Lai, Shikha Saxena, Maya Sabatello
Pages 753-762
Patient Navigation: Core Concepts and Relevance to the Field of Pediatric Neurodisability
Emily Gardiner, Anton R. Miller
Pages 763-771
Evaluating the Economic Impact of Neurodevelopmental Disability Intervention on the Family and Community
Jennifer D. Zwicker, Ramesh Lamsal
Pages 773-788
Resources
Front Matter
Pages 789-789
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Using Large-Scale Population-Based Data
Rubab G. Arim, Dafna E. Kohen
Pages 791-803
Tools for Knowledge Dissemination and Translation to Help Your Journey from Research to Impact
David J. Phipps, Anneliese Poetz
Pages 805-816
Back Matter
Pages 817-832
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