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Epidemiology
Pages 3-15
This book addresses neuroblastoma, a type of embryonic tumor derived from neural crest cells and one of the most frequent extra-cranial solid tumors in children. However, the term also describes a heterogeneous group of tumors, the prognosis of which can differ greatly according to age, stage and biology. Some forms undergo spontaneous regression, and some are cured by surgery alone or after chemo-reduction, while others exhibit extremely aggressive behavior. Their successful treatment is one of the best examples of tailored medicine, which involves close collaboration between pediatric surgeons, pediatric oncologists, radiologists, nuclear medicine specialists, biologists, oncogeneticists and radiotherapists.
The book pursues a unique approach, as it combines most essential insights from all of these fields, together with key information regarding epidemiology, physiopathology and palliative care. The respective chapters were written by the leading international experts on neuroblastoma, and present the latest advances in terms of research, surgical approaches and medical treatments. The book offers an invaluable resource to all pediatric surgeons, pediatricians, oncologists, students, researchers and all others involved in neuroblastoma management who want to benefit from their colleagues’ expertise.
Epidemiology
Pages 3-15
Biology of Neuroblastoma
Pages 17-28
Neuroblastoma Pathogenesis
Pages 29-56
Neuroblastoma Pathology
Pages 57-83
Radiology
Pages 87-117
Image-Defined Risk Factors
Pages 119-137
Nuclear Medicine Procedures in Neuroblastoma
Pages 139-162
Radiotherapy for Neuroblastoma
Pages 163-170
Spinal Canal Involvement in Peripheral Neuroblastic Tumors
Pages 173-189
Neonatal Neuroblastoma
Pages 191-203
Low- and Intermediate-Risk Neuroblastoma
Pages 205-212
High-Risk Neuroblastoma and Current Protocols
Pages 213-235
Immunotherapy
Pages 237-269
Prognostic Factors and Risk Stratification
Pages 271-292
Biopsy of Neuroblastoma
Pages 295-311
Surgical Techniques
Pages 313-325
Surgical Strategies for High Risk Neuroblastoma
Pages 327-336
Surgical Strategies for Neuroblastoma with Spinal Canal Involvement
Pages 337-342
Neuroblastoma: Minimally Invasive Surgery
Pages 343-355
Robotic Surgery for Neuroblastoma
Pages 357-362
Complications of the Surgical Management of Children with Neuroblastoma
Pages 363-374
Palliative Care
Pages 375-383
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