Informazioni
Non ci sono recensioni
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Neuraxial Therapeutics
A Comprehensive Guide
Yaksh, Hayek
Editore
Springer
Anno
2023
Pagine
830
ISBN
9783031395574
200,00 €
DA SCONTARE
This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics. It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy.
Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics, to be an invaluable guide to this treatment modality.
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Front Matter
Pages i-xix
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The History of Spinal Drug Delivery: The Evolution of Lumbar Puncture and Spinal Narcosis
- David C. Mackey
Pages 1-32
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The History and Evolution of Intrathecal Drug Delivery: From the 1950s to the Present
- Richard D. Penn, Tony L. Yaksh
Pages 33-46
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Development of the Spinal Cord
- Juraj Ševc, Anna Alexovič Matiašová, Zuzana Daxnerová
Pages 47-82
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Human Spinal Microanatomy
- Miguel Angel Reina, André P. Boezaart, Yury Zasimovich, Olga C. Nin, Alberto Prats-Galino, José De Andrés
Pages 83-99
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Spinal Anatomy of Experimental Animals
- Thomas F. Fletcher, Shelle A. Malkmus
Pages 101-120
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Spinal Cord Vasculature: General Anatomy and Physiology
- Jaroslav Pavel, Erika Kellerova, Jana Snopkova
Pages 121-149
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Cerebrospinal and Interstitial Fluids: Production, Outflow, and Circulation
- Stephen B. Hladky, Margery A. Barrand
Pages 151-185
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Emerging Insights into the Interstitial Distribution of Neuraxial Therapeutics via the Cerebrospinal Fluid Compartment
- Deidre J. Jansson, Jeffrey J. Iliff
Pages 187-221
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CSF Flow Dynamics in Relation to Intrathecal Drug Transport
- Andreas A. Linninger, Kevin Tangen, Ayankola O. Ayansiji, Daniel S. Gehrke, Indu Venugopal, Tony L. Yaksh et al.
Pages 223-253
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Cerebrospinal Fluid, the Meninges, and the Subarachnoid Space
- Tony L. Yaksh
Pages 255-288
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Animal Models of Neuraxial Drug Delivery
- Shelle A. Malkmus, Robert B. Boyd, Linda S. Sorkin, Tony L. Yaksh
Pages 289-314
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Preclinical Evaluation of Neuraxial Drugs for Safety
- Tony L. Yaksh, Robert B. Boyd, Orion Paul Keifer Jr.
Pages 315-346
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Histopathologic Examinations Following Neuraxial Drug Delivery
- Sarah D. Cramer, Mark T. Butt
Pages 347-361
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Formulation of Therapeutics for Neuraxial Infusion
- Carolyn A. Fairbanks, Cristina D. Peterson, Benjamin Michael Clements, Virginia L. Ghafoor, Tony L. Yaksh
Pages 363-388
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Compounding for Intrathecal Targeted Drug Delivery: A Comprehensive Guide
- William A. Stuart
Pages 389-398
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Intrathecal Delivery of Viral Vector-Mediated Gene Therapy
- Orion Paul Keifer Jr.
Pages 399-412
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Spinal Subpial Viral Vector Delivery in Treatment of Neurodegenerative Disorders
- Mariana Bravo-Hernández, Oleksandr Platoshyn, Joseph D. Ciacci, Martin Marsala
Pages 413-423
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Neuraxial Delivery of Targeted Toxins for Long-Term Pain Control
- Michael J. Iadarola, Matthew R. Sapio, Robert M. Caudle, David J. FitzGerald, Andrew J. Mannes
Pages 425-450
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Spinal Cellular Implants in Treatment of Neurodegenerative Disorders
- Yoshiomi Kobayashi, Joseph D. Ciacci, Martin Marsala
Pages 451-486
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Principles and Targets Underlying Spinal Analgesia
- Linda S. Sorkin, Elayne Vieira Dias, Tony L. Yaksh
Pages 487-504
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Review of Neuraxial Agents Producing Analgesia
- Elayne Vieira Dias, Linda S. Sorkin, Tony L. Yaksh
Pages 505-541
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Therapeutic Use of Neuraxial Drugs in Veterinary Medicine
- Alonso Guedes, Martin Kennedy
Pages 543-565
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Intrathecal Chemotherapy for Central Nervous System Malignancy
- Michele Antonio Capozza, Stefano Mastrangelo, Silvia Triarico, Antonio Ruggiero
Pages 567-582
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Targeted Drug Delivery to the CNS: Beyond the Intrathecal Space
- Daniel J. Abrams, Gregory R. Stewart
Pages 583-596
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Intrathecal Pharmacokinetics
- Christophe Perruchoud
Pages 597-604
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Intrathecal Drug Delivery for Pain: Medical Considerations
- Michael Hanes
Pages 605-611
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Intrathecal Drug Delivery for Pain: Psychological Considerations
- Daniel M. Doleys, Marilyn S. Jacobs
Pages 613-626
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Intrathecal Trialing Techniques for Pain Indications
- Jay S. Grider, Michael E. Harned
Pages 627-636
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Intrathecal Analgesics: Choices and Optimization of Delivery
- Jonathan M. Hagedorn, Nicholas Bremer, Timothy R. Deer, Jason E. Pope
Pages 637-643
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Maintenance and Troubleshooting of Intrathecal Therapy for Pain
- Ann Cai Shah, Gail L. McGlothlen, Lawrence Poree
Pages 645-661
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Intrathecal Therapy for Cancer Pain: Best Practices
- Melinda M. Lawrence, Amitabh Gulati
Pages 663-670
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Targeted Intrathecal Drug Delivery in Chronic Noncancer Pain: Best Practices
- Salim Michel Hayek
Pages 671-680
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Managing Complications of Intrathecal Medications Used for Pain
- Robert B. Bolash, Nagy Mekhail
Pages 681-692
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Assessing Patients with Movement Disorders for Intrathecal Therapy
- Hesham Abboud
Pages 693-698
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Neuraxial Trialing Techniques for Spasticity
- Michael E. Harned, Jay S. Grider
Pages 699-706
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Intrathecal Agents Used for Spasticity
- Francois Bethoux, Hesham Abboud
Pages 707-719
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Maintenance and Troubleshooting of Intrathecal Therapy for Spasticity
- Michael Saulino
Pages 721-728
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Intrathecal Drug Delivery Systems: Functional Characteristics and Tissue Reactivity
- Salim Michel Hayek, Tony L. Yaksh, Ashwini D. Sharan
Pages 729-753
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Preoperative Considerations
- Luke Campos, Jason E. Pope
Pages 755-759
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Intrathecal Pump Implantation: Technique and Precautions
- James North, Arun Ganesh
Pages 761-767
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Managing Surgical Complications of Intrathecal Pump Placement
- George M. Ghobrial, Jonathan P. Riley, Ashwini D. Sharan, Chengyuan Wu
Pages 769-773
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Special Patient Populations
- Michael D. Staudt, Eric Z. Herring, Berje H. Shammassian, Sonia A. Havele, Jerry Lipinski, Jennifer A. Sweet
Pages 775-786
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Managing and Minimizing Risk of Device Failure
- Ryan Galica, Bradford A. Jones, Salim Michel Hayek
Pages 787-801
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Cost-Effectiveness of Intrathecal Drug Delivery
- Rui V. Duarte, Lazaros Andronis
Pages 803-811
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Back Matter
Pages 813-830
