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An Introduction to Mitochondria, Their Structure and Functions
Pages 3-30
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Mitochondrial Dysfunction in Neurodegenerative Disorders
Reeve, Simcox, Duchen, Turnbull
Editore
Springer
Anno
2016
Pagine
380
ISBN
9783319286358
135,00 €
DA SCONTARE
This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets.
Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins.
Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.
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Neurodegeneration in Mitochondrial Disorders
Pages 33-58
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The Ageing Brain, Mitochondria and Neurodegeneration
Pages 59-80
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Mitochondrial Genes and Neurodegenerative Disease
Pages 81-106
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Mitochondrial Signaling and Neurodegeneration
Pages 107-137
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Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson’s Disease
Pages 141-173
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Mitochondrial Dynamics and Neurodegeneration
Pages 175-191
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Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation
Pages 193-217
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Mitochondria, the Synapse, and Neurodegeneration
Pages 219-239
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Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration
Pages 241-253
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Mitochondrial Degradation, Autophagy and Neurodegenerative Disease
Pages 255-278
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The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria
Pages 279-300
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Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration?
Pages 303-328
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Mitochondrial Function and Dynamics Imaged In Vivo
Pages 329-345
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Development of Treatments and Therapies to Target Mitochondrial Dysfunction
Pages 349-371
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Summary and Conclusions
Pages 373-376
