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Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.
1. Multiple Sclerosis, clinical course, open questions and unmet clinical needs
Howard Weiner, Jonathan Zurawski
2. Novel Imaging Approaches in Multiple Sclerosis
Mauricio Farez
3. Effect of infections on Multiple Sclerosis
Jorge Correale, Mariano Marrodan
4. T cells in Multiple Sclerosis.
Thomas Korn
5. B cells in Multiple Sclerosis.
Jennifer Gommerman, Angela Anran Wang
6. Microglia in Multiple Sclerosis.
Marco Prinz, Katharina Borst
7. Monocytes in Multiple Sclerosis
Burkhard Becher, Sara Pereira, Rachel Lindemann
8. Antigen Presenting Cells in Multiple Sclerosis.
Ari Waisman, Lisa Johann
9. Oligodendrocytes in Multiple Sclerosis.
Jack Antel, Florian Pernin
10. Astrocytes in Multiple Sclerosis.
Francisco Quintana
11. The Blood Brain Barrier in Multiple Sclerosis
Bettina Zierfuss
12. Microbiome in Multiple Sclerosis.
Sergio Baranzini
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