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Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. With an estimated 80% of people with diabetes living in disadvantaged regions, and the key roles of lipoproteins in the pathogenesis of the chronic complications of diabetes, this volume will be relevant to many readers globally. It is our intention that the contents will advance knowledge of the readers who will use it to contribute to the reduction of the burden associated with altered lipoproteins in people with diabetes.
The second edition of this book provides an updated and comprehensive review of the field. The book, which includes many tables and figures, is presented in three main sections: (i) Lipoprotein metabolism, qualitative changes and measurements; (ii) Lipoproteins and the complications of diabetes; and (iii) the treatment of lipoproteins in diabetes. Each chapter from the first edition has been updated, and new topics added. New topics include the links between glycemia and lipoproteins, the role of lipoproteins in ischemic stroke, the diagnosis and management of statin intolerance (which is thought to be more common in people with diabetes) and the use of PCSK9 inhibitors and fish oils in the management of lipoproteins in people with diabetes. This book is written by an international group of experts in the clinical, laboratory and research aspects of lipoproteins in diabetes.
Lipoproteins in Diabetes Mellitus, 2nd Edition is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It is a must-have resource for primary care and specialist clinicians, clinical and basic science researchers and to trainees and students.
Pages i-xx
Front Matter
Pages 1-1
Laboratory Assessment of Lipoproteins in Type 2 Diabetes
Pages 3-15
Tools for Assessing Lipoprotein Metabolism in Diabetes Mellitus
Pages 17-31
Links Between Glucose and Lipoproteins
Pages 33-54
Pages 55-109
Lipoprotein Metabolism and Alterations Induced by Insulin Resistance and Diabetes
Pages 111-143
Pages 145-167
Production and Metabolism of Triglyceride-Rich Lipoproteins: Impact of Diabetes
Pages 169-194
Pages 195-222
Pages 223-245
Lipoprotein(a): Metabolism, Pathophysiology, and Impact on Diabetes Mellitus
Pages 247-274
Lipoprotein Glycation in Diabetes Mellitus
Pages 275-318
Lipid: Extracellular Matrix Interactions as Therapeutic Targets in the Atherosclerosis of Diabetes
Pages 319-336
Front Matter
Pages 337-337
Pages 339-355
Endothelial Dysfunction in Type 2 Diabetes with an Update on New Interventions
Pages 357-406
Lipoproteins and Diabetic Kidney Disease
Pages 407-438
Lipids and Diabetic Retinopathy
Pages 439-464
Roles of Extravasated and Modified Plasma Lipoproteins in Diabetic Retinopathy
Pages 465-484
The Role of Lipids and Lipoproteins in Peripheral Neuropathy
Pages 485-502
Lipoproteins and Ischemic Stroke in Diabetes
Pages 503-522
Front Matter
Pages 523-523
About Randomized Clinical Trials Related to Lipoproteins in Diabetes Mellitus
Pages 525-553
Pages 555-577
Statin Therapy: Impact on Dyslipidemia and Cardiovascular Events in Patients with Diabetes
Pages 579-595
Statin Intolerance: An Overview for Clinicians
Pages 597-635
Pages 637-679
Pages 681-704
Pages 705-734
Pages 735-753
Clinical Care of Lipids in People with Type 1 Diabetes
Pages 755-778
Adjunct Drug Treatment to Reduce Vascular Disease in People with Diabetes
Pages 779-819
Emerging Lipoprotein-Related Therapeutics for Patients with Diabetes
Pages 821-878
Front Matter
Pages 879-879
Diabetes Epidemiology and Its Implications
Pages 881-890
Epidemiology, Control, and Cardiovascular Outcomes of Dyslipidemia in Diabetes
Pages 891-913
Pages 915-926
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