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Description
The purpose of this work is to provide an update on our understanding of lipids in the clinic using information from recent clinical trials and in special populations. This will be a concise, easy to read book. We will cover LDL, HDL and triglyceride metabolism in the first chapters. We will provide updates from recent HDL trials where raising HDL cholesterol did not translate into reduced cardiovascular events and revisit the role of HDL cholesterol in heart disease (Dr. Yassine). The vast majority of authors are confirmed. Dr. Goran will review lipids abnormalities in children with a particular focus on vulnerable populations (emphasis on ethnicity and childhood obesity). Dr. Goldberg will review the treatment goals for managing lipids in clinic. Dr. Abela will provide his expertise on the link between inflammation and lipids, and how this relates to atherosclerosis development. I invited Drs. Howard Hodis and Wendy Mack (world renowned experts on carotid imaging) to provide an update on measures of subclinical atherosclerosis in patients with abnormal lipid levels. Finally, I invited Dr. Michael Dube to provide an update on how new HIV medications impact lipid levels. Overall, this somewhat small book will be an excellent resource for understanding changes in lipids in different populations with an updated approach to managing complicated lipid cases.
Table of Contents
1 Basics in Lipoprotein Metabolism 1
Hussein Yassine, Keenia Tappin and Muhammad Jawad Sethi
2 Genetics of Lipid Disorders 17
Marija Stojanova Jordanov
3 Lipid and Inflammation in Atherosclerosis 37
Imad Ahmado, Oliver G. Abela, Muhamad Adeeb Safiia, Abed Janoudi
and George S. Abela
4 Dyslipidemia: Relationship to Insulin Resistance, Fatty
Liver, and Sub-Clinical Atherosclerosis 65
Claudia M. Toledo-Corral, Tanya L. Alderete and Michael I. Goran
5 Is Low HDL Cholesterol a Marker or a Mediator of
Cardiovascular Disease? 81
Hussein Yassine
6 Title: Approach to the Patient with Lipid Disorders 91
Kelsey Michiko Shikuma Lee and Hussein Yassine
7 The Effects of Diet in Hyperlipidemia 113
Joseph Michael Allevato and Imelda Allevato
8 Statins 123
Marija Stojanova Jordanov and Hiba Abou Assi
9 Non-Alcoholic Fatty Liver Disease (NAFLD): The Lipid
Disease of the Liver and the Effect of Statins 149
Mazen Noureddin, David Alexanian and Neil Kaplowitz
10 The Role of Statins in Heart Failure 175
Allen Kuo and Michael Fong
11 Statins in Chronic Kidney Disease 187
Sahar H. Koubar
12 Non-Statin Treatment of Dyslipidemia 201
Stanley J. Goldberg
13 LDL Apheresis 233
Hedyeh Shafi, Holli M. Mason and Ellen Klapper
14 Dyslipidemia in HIV 241
Michael P. Dubé
15 New and Emerging Therapies for Hyperlipidemia 257
Michael J. Wong
Index 267
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