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The field of kidney cancer has dramatically evolved over the past several years due to notable advances. Most importantly, systemic treatment options have expanded to include combination regimens for advanced disease and expansion of treatment options in the adjuvant setting. Additionally, surgical management has evolved towards nephron-sparing and minimally invasive approaches for treatment of localized disease; the role of surgery and focal therapy are changing for patients with advanced disease. While kidney cancer is a common malignancy in both men and women worldwide, mortality has improved over time given advancements in modern oncology.
This book provides a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in kidney cancer. The book reviews new data about systemic treatment options for patients with advanced disease including strategies in the treatment naïve and post frontline setting. It covers new data regarding perioperative and adjuvant treatments for patients with localized disease and will highlight novel targets and treatments under development. Integration of surgery and systemic therapy through cytoreductive and consolidative approaches has yielded provocative data that promises to further advance the field, and major advances in this domain will also be discussed. Additionally, the book discusses the evolving role of alternative focal approaches including radiation therapy for patients with advanced disease.
This text serves as a very useful resource for physicians and researchers dealing with and interested in this challenging malignancy. Specifically, urologists, medical oncologists, radiation oncologists, basic science and translational researchers with interest in RCC, fellows in urologic oncology, upper level residents training in urology and medical oncology, and pharmaceutical partners interested in RCC will benefit most significantly. Integrating Multidisciplinary Treatment for Advanced Renal Cell Carcinoma will provide a concise yet comprehensive summary of strategies for sequencing therapies that will help guide patient care and stimulate investigative efforts.
Pages i-vi
Front Matter
Pages 1-1
Prognostic Factors for Localized Renal Cell Carcinoma
Pages 3-18
Active Surveillance of Patients with Clinically Localized Small Renal Masses
Pages 19-45
Partial Nephrectomy in the Treatment of RCC
Pages 47-72
Ablative Options for Renal Cell Carcinoma
Pages 73-90
Radical Nephrectomy for Renal Cell Carcinoma
Pages 91-109
Surgical Management of Hereditary Kidney Cancer Syndromes
Pages 111-140
Front Matter
Pages 141-141
Management of Renal Cell Carcinoma with IVC Thrombus, Nodal Involvement, and T4 Disease
Pages 143-181
Adjuvant Therapies in Renal Cell Carcinoma
Pages 183-194
Neoadjuvant Therapy in Locally Advanced Renal Cell Carcinoma
Pages 195-229
Front Matter
Pages 231-231
Prognostic Factors in Advanced Renal Cell Carcinoma
Pages 233-250
Predictive Biomarkers in Advanced Renal Cell Carcinoma
Pages 251-268
First-Line Systemic Treatment Options for Advanced Renal Cell Carcinoma
Pages 269-292
Subsequent Line Systemic Treatment Options for Advanced Renal Cell Carcinoma
Pages 293-308
Novel Targets in Development for Advanced Renal Cell Carcinoma
Pages 309-342
Pages 343-357
Systemic Therapies for Advanced Non-Clear Cell Renal Cell Carcinoma
Pages 359-375
Approach to Special Populations with Advanced Renal Cell Carcinoma
Pages 377-397
Integration of Palliative Care into the Renal Cancer Treatment Paradigm
Pages 399-414
Pages 415-422
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