Titolo: Innovative Neuromodulation

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Innovative Neuromodulation

Editore

Elsevier - Academic Press

Anno

2017

Pagine

340

ISBN

9780128004548

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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Description

Innovative Neuromodulation serves as an extensive reference that includes a basic introduction to the relevant aspects of clinical neuromodulation that is followed by an in-depth discussion of the innovative surgical and therapeutic applications that currently exist or are in development.

This information is critical for neurosurgeons, neurophysiologists, bioengineers, and other proceduralists, providing a clear presentation of the frontiers of this exciting and medically important area of physiology. As neuromodulation remains an exciting and rapidly advancing field—appealing to many disciplines—the editors’ initial work (Essential Neuromodulation, 2011) is well complemented by this companion volume.

Key Features

Presents a comprehensive reference on the emerging field of neuromodulation that features chapters from leading physicians and researchers in the field
Provides commentary for perspectives on different technologies and interventions to heal and improve neurological deficits
Contains 300 full-color pages that begin with an overview of the clinical phases involved in neuromodulation, the challenges facing therapies and intraoperative procedures, and innovative solutions for better patient care

Biographies
List of Contributors
Preface
Acknowledgments
Introduction—Opportunities and Challenges
- References
Section I: Creativity Theory and Performing Artists
- Chapter 1. Microarrays in the Brain: Can They Be Used for Brain–Machine Interface Control?
  - Abstract
  - Building a Brain–Machine Interface
  - The Architecture of a Brain–Machine Interface
  - What Does the Motor Cortex Do?
  - Low Performance Level and Limited Ability to Generalize
  - So the Answer to What the Motor Cortex Does Is…
  - Future Possibilities
  - Direct Control Versus Indirect Decoding
  - Concluding Remarks
  - Acknowledgments
  - References
- Chapter 2. Feedback-Sensitive and Closed-Loop Solutions
  - Abstract
  - Introduction
  - Cranial Nerve Electrical Stimulation for Seizure Control
  - Brain Stimulation for Epilepsy: Historical Perspective
  - Brain Stimulation In Vitro and In Vivo
  - Thalamic Brain Stimulation
  - Location of Brain Stimulation
  - Electrical Parameters for Brain Stimulation
  - Possible Mechanisms of Action
  - Closed-Loop Brain Stimulation
  - Clinical Applications
  - The RNS System: Pivotal and Long-Term Results
  - Seizure Prediction
  - Adverse Effects and Technical Challenges
  - Summary
  - References
- Chapter 3. Directional Deep Brain Stimulation
  - Abstract
  - Deep Brain Stimulation Inhibits Neuronal Firing
  - DBS Hardware
  - Accurate DBS Lead Targeting and Placement is Critical for Success of the Therapy
  - Directional DBS Leads Confer Several Benefits
  - Directional DBS in Parkinson’s Disease and Essential Tremor
  - Directional DBS Clinical Proof of Concept
  - Application of Directional DBS to Other Diseases
  - References
- Chapter 4. Waveform Variation in Neuromodulation
  - Abstract
  - Introduction
  - Modifications of Traditional Waveform Parameters and Shapes
  - Deep Brain Stimulation
  - Spinal Cord Stimulation
  - Other Considerations
  - References
Section II: New Modes of Therapy
- Chapter 5. Ultrasound Neuromodulation: A Chapter for Innovative Neuromodulation
  - Abstract
  - Introduction
  - Physics of Ultrasound
  - Historical Perspective of Ultrasonic Neuromodulation
  - Experimental Cortical Neuromodulation
  - Neuromodulation of Visual-Evoked Potentials
  - Experimental Neuromodulation of Deep Cerebral Structures
  - Hippocampal Neuromodulation With Ultrasound
  - Cortical Neuromodulation in Large Animals and Humans
  - Mechanisms of Ultrasonic Neuromodulation
  - Clinical Applications of FUS Neuromodulation
  - Future Clinical Applications of FUS Neuromodulation
  - Conclusions
  - References
- Chapter 6. Optogenetics
  - Abstract
  - Introduction
  - Opsins
  - In Vivo Optogenetic Applications
  - Outlook: Nonhuman Primates and Human Tissue
  - References
- Chapter 7. Introduction to Basic Mechanisms of Transcranial Magnetic Stimulation
  - Abstract
  - Introduction
  - Transcranial Magnetic Stimulation
  - Basic Principles of Nerve Stimulation With Magnetic Pulses
  - Effect of TMS on Motor Cortex
  - I-Waves
  - TMS of Motor Cortex Excites Inhibitory as Well as Excitatory Neurons: Paired Pulse Evidence
  - Models
  - Synaptic Plasticity
  - References
- Chapter 8. Transcranial Direct Current Stimulation: From Historical Foundations to Future Directions
  - Abstract
  - History
  - Technical Aspects
  - Parameters of Stimulation
  - Safety
  - Clinical Application
  - Future Directions
  - Conclusion
  - References
- Chapter 9. Viral Vectors and Other Modulatory Biologics
  - Abstract
  - Introduction
  - Viral Vectors
  - Adenovirus
  - Adeno-Associated Virus
  - Herpes Simplex Virus
  - Lentivirus (Retrovirus)
  - Nonviral Vector-Mediated Gene Therapy
  - Viral-Mediated Neuromodulation and Gene Therapy for Neurological Disease
  - Parkinson Disease
  - Chronic Pain
  - Epilepsy
  - Psychiatric Disorders
  - Conclusions
  - References
Section III: Innovative Thinking
- Chapter 10. Neuroprosthetic Advances
  - Abstract
  - Introduction
  - From an Electrophysiological “Brace” Toward a Neuroprosthetic Device
  - Neuroprosthetic Devices for Control of Movement via Peripheral Sensory Nerve Stimulation
  - Neuroprosthetic Devices Based on Spinal Cord Stimulation of Posterior Structures of the Spinal Cord
  - Neuroprosthesis for Motor Control Available Today
  - References
- Chapter 11. Neuromodulation for Memory
  - Abstract
  - Introduction
  - Validation of Hemispheric Encoding-Retrieval Asymmetry (HERA) Model
  - Motor Memory—Interhemispheric Competition Model
  - Recovery of Motor Memory After Stroke
  - Deep Brain Stimulation for Declarative Memory and Dementia
  - Optogenetic Isolation of Memory Engrams
  - Conclusion
  - Key Questions
  - References
- Chapter 12. Deep Brain Stimulation for Vegetative State and Minimally Conscious State
  - Abstract
  - Introduction
  - Patients and Methods
  - Results
  - Discussion and Conclusions
  - References
- Chapter 13. Neuromodulation as a Bypass—Spinal Cord Injury
  - Abstract
  - Introduction
  - Recording
  - Proof of Concept
  - Results
  - Discussion
  - Conclusion
  - Acknowledgments
  - References
- Chapter 14. Neuromodulation for Psychiatric Disorders
  - Abstract
  - Introduction
  - Accepted Indications
  - Experimental
  - Neuromodulation in Other Psychiatric Indications
  - Conclusion
  - References
Index