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This book encompasses an up-to-date, comprehensive review of the state-of-the-art for prostate gland preserving therapies. It provides insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, image-targeted therapy methods.
Imaging and Focal Therapy of Early Prostate Cancer, Third Edition opens with a discussion of why patients and clinicians should consider focal therapy, then moves on to consider the question of active surveillance versus focal therapy from a global perspective, with chapters on North American, European, Southeast Asian, and South American perspectives. From there, chapters cover the scientific foundation of focal therapy, current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance imaging, etc.) and various biopsy techniques. Following this is detailed coverage of patient selection, treatment strategy, adjuvants to enhance therapy, outcomes, and patient centered interests, followed by a discussion of the strengths and limitations of various therapeutic modalities, such as cryotherapy, high intensity focused ultrasound, and photodynamic therapy, follows. The final sections of the book cover the assessment of focal therapy outcomes and look forward to the future of focal therapy for prostate cancer.
Written by experts in the field and lavishly illustrated with detailed line-art and photographs, this text is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, residents, fellows, nurses and allied professionals, and researchers with an interest in the diagnosis and novel targeted treatment of prostate cancer.
Pages i-xxiii
Front Matter
Pages 1-1
Focal Therapy for Prostate Cancer: A Guide for Patients
Pages 3-14
The Story of Breast and Prostate Cancer: Parallels and Common Controversies
Pages 15-23
Focal Ablative Therapy for Localized Kidney Cancer
Pages 25-45
The Patient’s Perspective: What Does the Patient Want?
Pages 47-52
Front Matter
Pages 53-53
Pages 55-61
Focal Therapy and Active Surveillance of Prostate Cancer: A European Perspective
Pages 63-78
Focal Therapy and Active Surveillance of Prostate Cancer in East and South-East Asia
Pages 79-85
Acceptance and Challenges in the Adoption of Focal Therapy for Prostate Cancer in South America
Pages 87-93
Front Matter
Pages 95-95
Pages 97-102
Identifying and Characterizing the Index Lesion
Pages 103-109
Utility of Biopsy-Based Genomic Assays to Risk Stratify Patients for Active Treatment
Pages 111-116
Pages 117-122
Differences Between MRI-Visible Vs. MRI-Invisible Cancers: Biology and Outcomes
Pages 123-131
Front Matter
Pages 133-133
Pages 135-154
Employing a Quality Improvement Program to Optimize mpMRI-Directed Fusion Biopsy
Pages 155-167
Multiparametric Ultrasound for Prostate Imaging and Targeting
Pages 169-178
Staging Imaging for Focal Therapy of Prostate Cancer
Pages 179-186
Front Matter
Pages 187-187
Multiparametric MRI/TRUS Fusion Biopsy, Outcomes, and Commercial Systems
Pages 189-210
Comparison of Outcomes with Transperineal Versus Transrectal Image-Targeted Prostate Biopsy
Pages 211-218
Pages 219-240
Diagnostic Performance of PET-Based Targeted Fusion Biopsy in Prostate Cancer
Pages 241-253
Optimizing Biopsy Core Quality for Diagnosis
Pages 255-260
Front Matter
Pages 261-261
Pages 263-273
Prostate Focal Therapy: Definitions and Common Terminology
Pages 275-280
Focal Therapy for Anterior Cancers
Pages 281-290
Office-Based Outpatient Focal Therapy Under Local Anesthesia
Pages 291-313
Front Matter
Pages 315-315
Focal Brachytherapy (Interventional Radiotherapy) and IMRT
Pages 317-326
Pages 327-344
Irreversible Electroporation for Partial Gland Ablation: Clinical Application and Outcomes
Pages 345-351
Front Matter
Pages 353-353
Role of Transurethral Ultrasound Ablation (TULSA) in Prostate Cancer Focal Therapy
Pages 355-372
Transurethral Vapor Ablation in Prostate Cancer
Pages 373-386
Front Matter
Pages 387-387
Robotic High-Intensity Focused Ultrasound of the Prostate
Pages 389-403
Transrectal Laser Focal Therapy of Prostate Cancer
Pages 405-416
Front Matter
Pages 417-417
Role of Prostate MRI for Postfocal Treatment Assessment and Surveillance
Pages 419-429
Pages 431-439
Assessing Functional Outcomes After Focal Therapy
Pages 441-448
Biochemical Assessment of Cancer Outcomes Following Focal Therapy
Pages 449-454
Pathologic Assessment and Implications Following Focal Therapy of Prostate Cancer
Pages 455-468
Salvage Treatment Following Focal Therapy
Pages 469-474
Front Matter
Pages 475-475
Pages 477-488
The Horizon: Future of Focal Therapy in Prostate Cancer
Pages 489-492
Pages C1-C1
Pages 493-502
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