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Pathology of Histiocytic Disorders and Neoplasms and Related Disorders
Pages 3-50
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Histiocytic Disorders
Abla, Janka
Editore
Springer
Anno
2018
Pagine
392
ISBN
9783319596310
130,00 €
DA SCONTARE
This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses.
Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.
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Biology and Genomics of LCH and Related Disorders
Pages 53-71
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Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in Children
Pages 73-85
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Central Nervous System Langerhans Cell Histiocytosis
Pages 87-101
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First-Line Treatment of Pediatric Langerhans Cell Histiocytosis
Pages 103-118
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Treatment of Relapsed and Refractory Langerhans Cell Histiocytosis in Children
Pages 119-137
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Adult Langerhans Cell Histiocytosis
Pages 139-153
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Late Effects of Langerhans Cell Histiocytosis and the Association of LCH with Malignancy
Pages 155-170
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Classification, Clinical Manifestations, and Diagnostics of HLH
Pages 173-187
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CNS Involvement in HLH (CNS-HLH)
Pages 189-196
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Genetics and Pathogenesis of Hemophagocytic Lymphohistiocytosis
Pages 197-214
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Hemophagocytic Lymphohistiocytosis Associated with Malignancies and with Epstein-Barr Virus
Pages 215-231
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Macrophage Activation Syndrome in Rheumatic Diseases (MAS-HLH)
Pages 233-246
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Treatment of Newly Diagnosed HLH and Refractory Disease
Pages 247-263
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Hematopoietic Cell Transplantation and Novel Therapies in Hemophagocytic Lymphohistiocytosis
Pages 265-274
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HLH in Adults
Pages 275-290
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Juvenile Xanthogranuloma and Related Non-LCH Disorders
Pages 293-311
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Erdheim-Chester Disease
Pages 313-338
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Rosai–Dorfman Disease
Pages 339-360
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Malignant Histiocytoses
Pages 361-381
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Erratum to: Histiocytic Disorders
Pages E1-E1
