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Introduction
Pages 1-4
Representing a state-of-the-art appraisal of this viral infection and its complications, this book comprises contributions from international authorities in infectious diseases, varicella-voster virus infections, and neuropathic pain. Important new information is presented on the role of the virus in terms of vascular risk, notably in heart attack, stroke and granulomatous angiitis (temporal arteritis). Similarly, new information on gastrointestinal involvement, often in the absence of rash and as seen with vasculopathies, is covered. The reader will benefit from new research into the pathology, pathophysiology and treatment of postherpetic neuralgia and its complications, and special attention is paid to prevention through zoster vaccination using the current zoster vaccine, and a novel, broader option that can be used in immunocompromised patients.
This book follows the two editions of the book, Herpes Zoster and Postherpetic Neuralgia, and is divided into sections for the convenience of the reader. A section on herpes zoster includes epidemiology and natural history of the varicella zoster virus, herpes zoster ophthalmicus, neurological complications, the role of varicella zoster virus in giant cell arteritis, concern about increased vascular risk of heart attack and stroke, antiviral therapy, and treatment of skin manifestations. A section on postherpetic neuralgia includes important information on the effect of herpes zoster and postherpetic neuralgia on quality of life, the neuropathology and pathophysiological mechanisms in postherpetic neuralgia, and the new concept of persistent ganglionitis as the cause of postherpetic neuralgia. A comparison is made between facial postherpetic neuralgia and trigeminal neuralgia. There is an extensive section on treatment, including the role of opioids, the general treatment of postherpetic neuralgia, intervention and neurosurgical approaches, and covering guidelines for clinical trial designs in postherpetic neuralgia. A final section addresses the questions of whether aggressive treatment of acute herpes zoster can prevent postherpetic neuralgia and includes a critically important chapter on herpes zoster vaccines.
Introduction
Pages 1-4
Varicella
Pages 7-15
Herpes Zoster: A Patient’s Perspective
Pages 19-23
The Epidemiology and Natural History of Herpes Zoster and Postherpetic Neuralgia
Pages 25-44
Herpes Zoster Ophthalmicus
Pages 45-59
Neurological Complications of Herpes Zoster
Pages 61-75
The Role of Varicella Zoster Virus in Giant Cell Arteritis
Pages 77-84
Herpes Zoster and Vascular Risk
Pages 85-96
Antiviral Therapy and Local Treatment for Herpes Zoster
Pages 97-102
Dermatologic Manifestations of Herpes Zoster
Pages 103-115
The Effect of Herpes Zoster and Postherpetic Neuralgia on Health-Related Quality of Life, Function, Employment-Related Productivity, and the Cost-Effectiveness of the Vaccine
Pages 119-140
The Pathology of Postherpetic Neuralgia and Postherpetic Itch
Pages 141-156
Neural Basis of Pain in Herpes Zoster and Postherpetic Neuralgia: The Ectopic Pacemaker Hypothesis
Pages 157-187
Persistent VZV Ganglionitis May Be the Cause of Postherpetic Neuralgia
Pages 189-195
A Comparison of Clinical Features and Mechanisms of Trigeminal Postherpetic Neuralgia and Trigeminal Neuralgia
Pages 197-226
Treatment of Postherpetic Neuralgia: Subtypes and a Mechanism-Based Treatment
Pages 229-238
Interventional Approaches to Postherpetic Neuralgia
Pages 239-251
Treatment of Postherpetic Neuralgia: The Role of Opioids
Pages 253-277
Postherpetic Neuralgia: Difficult to Treat, Easier to Prevent
Pages 279-296
Postherpetic Neuralgia: Are There Neurosurgical Options?
Pages 297-313
Designing Randomized Controlled Trials of Oral Analgesics for Chronic Postherpetic Neuralgia
Pages 315-331
The Importance of Zoster Prevention Vaccines
Pages 335-339
Aggressive Noninvasive Treatment of Acute Herpes Zoster for the Prevention of Postherpetic Neuralgia
Pages 341-364
Herpes Zoster Vaccines
Pages 365-418
Conclusion: “All Roads Lead to Rome”
Pages 419-419
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