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Natural History of Chronic Hepatitis C
Pages 3-55
This book helps scientists, clinicians and other interested individuals understand recent clinical advances and challenges for the future. It covers many basic aspects of the pathogenesis of chronic hepatitis C, HCV infections in particular populations, approaches to therapy, and prevention and control of HCV Infection. The book provides a succinct review of the large amount of data generated by multiple groups over the past two decades that has revealed the natural history of HCV infection. Similarly, it summarizes current understanding of the origins of HCV-associated hepatocellular carcinoma, cirrhosis and hepatic fibrosis. Extra-hepatic manifestation and metabolic disorders related to HCV infection are described. In this volume, these clinically important aspects of HCV infection are comprehensively described. Highlights are description of newly developed direct- acting antivirals. The authors represent a worldwide distribution of leaders in the field reflecting the global nature of HCV infection. Based on recent data concerning the genetic- and geographical diversity of HCV, and increased global disease burden of HCV infection, challenges for global control of HCV infections are described.
Natural History of Chronic Hepatitis C
Pages 3-55
The Multifaceted Features of HCV Infection Beyond the Liver
Pages 57-78
Hepatic Fibrosis in Hepatitis C
Pages 79-108
Hepatocellular Carcinoma and Hepatitis C Virus
Pages 109-136
HCV, Alcohol, and the Liver
Pages 137-163
Extrahepatic Replication of HCV
Pages 165-184
Hepatitis C Virus Infection in Pregnancy and Childhood
Pages 187-222
Host Genetics and Responses to Antiviral Therapy in Chronic Hepatitis C
Pages 225-241
Viral Variation and Response to Therapy
Pages 243-256
HCV NS3/4A Protease Inhibitors and the Road to Effective Direct-Acting Antiviral Therapies
Pages 257-285
Mechanism of Action of Direct-Acting Antivirals: New Insights into the HCV Life Cycle
Pages 287-301
Modeling HCV Dynamics in Clinical Practice to Personalize Antiviral Therapy
Pages 303-321
Prophylactic Vaccines for the Hepatitis C Virus
Pages 325-346
Global Control of Hepatitis C Virus Infection
Pages 347-368
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