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Features:
1. Historical Background
2. Factor VIII: Anatomy and Physiology
A. Isolation & Relationship to the Von Willebrand Factor
B. Structure
C. Cell of Origin, Secretion, & Clearance
D. Participation in Hemostasis & Inactivation
3. Genetic Basis of Hemophilia
A. Factor VIII gene
B. Mutations
C. Hemophilia in Women
D. Carrier Detection & Prenatal Diagnosis
4. Factor VIII Therapy for Bleeding
A. Plasma and Cryoprecipitate
B. Recombinant Factor VIII
C. Gene Therapy
5. Complications of Therapy
A. Allergic Reactions
B. Thrombosis
C. Alloantibodies
6. Acquired Disorders of Factor VIII
A. Autoantibodies
B. Non-immunologic
7. Factor VIII and Thrombosis
A. Genetic disorders
B. Hormones
C. Role in Thrombosis
D. Antithrombotic Therapy
8. Factor VIII: Future Directions
A. Re-engineering FVIII for oral or topical administration
B. Decreasing FVIII immunogenicity
C. Anti-thrombotics that block FVIII
D. Genetic and cell-based approaches
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