14 Sézary syndrome........................................................... 143
Ellen J. Kim, Paul Haun, Martine Bagot,
Maxime Battistella, and András Schaffer
15 Primary cutaneous CD30-positive T-cell
lymphoproliferative disorders......................................... 158
Rebecca L. King, Werner Kempf, Amy C. Musiek,
and Andrew L. Feldman
16 Subcutaneous panniculitis-like T-cell lymphoma............ 178
Alejandro A. Gru, Laura Beth Pincus, and
Yann Charlie-Joseph
17 Cutaneous CD4 small to medium
+
lymphoproliferative disorder and other
proliferations with TFH phenotype.................................. 193
Sanam Loghavi, Farrah Bakr, Helmut Beltraminelli,
Alistair M. Robson, and Michael T. Tetzlaff
18 Aggressive cytotoxic primary cutaneous T-cell
lymphomas.................................................................... 203
Jacqueline M. Junkins-Hopkins and Ellen J. Kim
19 Primary cutaneous peripheral T-cell lymphoma, not
otherwise specified........................................................ 220
Alistair M. Robson, Andy C. Hsi, Amy C. Musiek,
and András Schaffer
20 Primary cutaneous CD8 acral lymphoproliferative
+
disorder......................................................................... 225
Alistair M. Robson, Farrah Bakr, Melissa Pulitzer,
and Werner Kempf
21 Granulomatous CD8-positive lymphoproliferative
disorder associated with immunodeficiency................... 233
Werner Kempf and Christina Mitteldorf
22 An approach to the treatment of mycosis
fungoides/Sézary syndrome and CD30 positive
lymphoproliferative disorders......................................... 238
Pietro Quaglino, Egle Ramelyte, Andrea Roggo,
Crystal Gao, Rein Willemze, Stephen Lade,
and H. Miles Prince
Contributors.............................................................................. vii
Preface.................................................................................... xiii
Part I
Immunobiology and Molecular Pathogenesis 1
1 Cutaneous T-cell immunobiology. ...................................... 1
Emmanuella Guenova, Andy C. Hsi, and András Schaffer
2 Cutaneous B-cell immunobiology..................................... 12
Alejandro A. Gru and José Cabeçadas
3 NK cell immunobiology.................................................... 21
Aharon G. Freud and Madelie Sellers
4 Mononuclear phagocytic system of the skin–guide to
pathologists..................................................................... 26
Kate Roussak and Eynav Klechevsky
5 Mast cells in the skin....................................................... 34
Tina L. Sumpter
6 Molecular pathogenesis of primary cutaneous T-cell
lymphomas...................................................................... 40
Sean Whittaker
7 Molecular pathogenesis of primary cutaneous
B-cell lymphomas............................................................ 50
Alejandro A. Gru and Pierluigi Porcu
Part II
Laboratory Techniques 59
8 Flow cytometric analysis in hematopathology diagnosis..... 59
Safa Najidh, Julia Almeida, Jacques J. M. van Dongen,
and Maarten H. Vermeer
9 PCR-based gene rearrangement studies.......................... 73
Ian S. Hagemann
10 FISH and cytogenetic techniques. .................................... 81
Andrea L. Salavaggione and Alejandro A. Gru
11 Next-generation sequencing............................................ 97
Ian S. Hagemann
Part IV
Primary Cutaneous NK/T-Cell Malignancies
256
Part III
Primary Cutaneous T-Cell Lymphomas
23 Extranodal natural killer/T-cell lymphoma,
nasal type...................................................................... 256
Carlos Barrionuevo-Cornejo and
Leticia Quintanilla-Martinez
24 Hydroa vacciniforme lymphoproliferative disorder.......... 262
Jose A. Plaza and J. Martin Sangueza
25 Natural killer–cell leukemias/lymphomas....................... 270
Aharon G. Freud and Madelie Sellers
103
12 Approach to the diagnosis of primary cutaneous
T-cell lymphomas.......................................................... 103
Alistair M. Robson, Alejandro A. Gru, and András Schaffer
13 Mycosis fungoides......................................................... 109
Alistair M. Robson, Rein Willemze, Julia Scarisbrick,
Amy C. Musiek, Emmilia Hodak, Alejandro A. Gru,

Part V
Systemic T- and NK-Cell Lymphomas With Cutaneous
Dissemination 280
26 Systemic anaplastic large cell lymphoma....................... 280
Alejandro A. Gru and Werner Kempf
27 T-cell prolymphocytic leukemia...................................... 291
Alejandro A. Gru
28 Skin manifestations of angioimmunoblastic T-cell
lymphoma. .................................................................... 298
Nicolas Ortonne
29 Adult T-cell leukemia/lymphoma.................................... 311
Melissa Pulitzer
42 Cutaneous plasma-cell neoplasms................................. 474
Liaqat Ali, Jozef Malysz, and José Cabeçadas
43 Cutaneous involvement by Hodgkin’s lymphoma............ 480
Alejandro A. Gru, András Schaffer, and Maxime Battistella
Part VIII
Cutaneous Reactive Infiltrates 492
44 Pityriasis lichenoides chronica....................................... 492
Emily Y. Chu and Werner Kempf
45 Jessner lymphocytic infiltrate and tumid lupus
erythematosus............................................................... 498
Juanita Duran and Jose A. Plaza
46 Pigmented purpuric dermatoses.................................... 503
Casey A. Carlos
47 Chronic actinic dermatitis—actinic reticuloid................. 506
Sena J. Lee and András Schaffer
48 CD30 pseudolymphomas............................................... 510
Jacqueline M. Junkins-Hopkins and Werner Kempf
49 Pseudolymphomatous reactions with associated
cutaneous neoplastic proliferations................................ 525
Sara C. Shalin and Bruce R. Smoller
50 Cutaneous lymphoid hyperplasia and related
entities. ......................................................................... 542
Alejandro A. Gru
51 Pseudolymphomas at sites of vaccination and
in tattoos....................................................................... 562
Priyadharsini Nagarajan
52 Lymphoid proliferations in association with viral
and bacterial infections.................................................. 567
Priyadharsini Nagarajan
53 Cutaneous plasmacytosis. ............................................. 572
M. Yadira Hurley and Gillian Heinecke
54 Cutaneous IgG4-related disease. ................................... 577
Alejandro A. Gru
55 Lymphomatoid contact dermatitis.................................. 582
Caitlin M. Brumfiel, Meera H. Patel, Alejandro A. Gru,
and Matthew J. Zirwas
56 Annular lichenoid dermatosis of youth. .......................... 588
Alejandro A. Gru
57 Eosinophilic dermatosis of hematologic malignancy....... 592
Joya Sahu and Jason B. Lee
Part IX
Precursor Lymphoid and Myeloid Neoplasms 598
58 Precursor B- and T-cell neoplasms. ............................... 598
Alejandro A. Gru and Maxime Battistella
59 Leukemia cutis/aleukemic leukemia cutis/myeloid
sarcoma........................................................................ 608
Kari E. Sufficool and John L. Frater
60 Cutaneous manifestations of myeloproliferative
neoplasms..................................................................... 621
Richard Danialan and Carlos A. Torres-Cabala
Part VI
Primary Cutaneous B-Cell Lymphoproliferative
Disorders
322
30 Approach to the diagnosis of cutaneous B-cell
lymphomas.................................................................... 322
Alejandro A. Gru and Elaine S. Jaffe
31 Primary cutaneous follicle center B-cell lymphoma........ 336
Antonio Subtil and Michi M. Shinohara
32 Primary cutaneous marginal zone B-cell lymphoma....... 347
Katalin Ferenczi, Farrah Bakr, and Alistair M. Robson
33 Primary cutaneous diffuse large B-cell lymphoma. ........ 360
Christina MItteldorf, Alejandro A. Gru,
and José Cabeçadas
34 Lymphomatoid granulomatosis...................................... 378
Yasmin Hambaroush and Alejandro A. Gru
35 Mucocutaneous EBV- and HHV-8 associated
lymphoproliferative disorders in acquired
immunodeficiency. ........................................................ 388
Alejandro A. Gru, Melissa Pulitzer, and András Schaffer
36 An approach to the treatment of primary cutaneous
B-Cell lymphomas. ........................................................ 405
Pablo L. Ortiz-Romero and Mariana Cravo
Part VII
Systemic B-Cell Lymphomas With Cutaneous
Dissemination
413
37 Systemic follicular lymphoma, marginal zone
lymphomas, and lymphoplasmacytic lymphoma. ........... 413
Alejandro A. Gru and Antonio Subtil
38 Intravascular large B-cell lymphoma.............................. 423
Alejandro A. Gru and Maxime Battistella
39 Cutaneous involvement in systemic diffuse large
B-cell lymphomas.......................................................... 431
Alejandro A. Gru and Yvonne Perner
40 Cutaneous mantle cell lymphoma.................................. 455
José Cabeçadas and Alejandro A. Gru
41 Cutaneous manifestations of chronic lymphocytic
leukemia/small lymphocytic lymphoma.......................... 463
Alejandro A. Gru and Maxime Battistella

61 Cutaneous extramedullary hematopoiesis...................... 635
Shadi Khalil and András Schaffer
62 Blastic plasmacytoid dendritic cell neoplasm. ................ 638
M. Yadira Hurley, Joseph D. Khoury, Alejandro A. Gru,
Tony Petrella, and Martin Dittmer
Part X
Cutaneous Mast Cell Proliferations 650
63 Mast cell neoplasms...................................................... 650
Clive E. Grattan and Hans-Peter Horny
Part XI
Benign and Malignant Histiocytic Disorders 664
64 Molecular classification of histiocytoses......................... 664
Jennifer Picarsic and Benjamin H. Durham
65 Langerhans cell proliferations and related
disorders (“L” group)...................................................... 674
Jacob R. Bledsoe, Jennifer Picarsic, Louis P. Dehner,
and Rosalynn M. Nazarian
66 Rosai–Dorfman disease................................................. 684
Kristin C. Smith and M. Yadira Hurley
67 Non-Langerhans cell histiocytoses (C and H groups)...... 690
Andrea P. Moy, Jacob R. Bledsoe, Louis P. Dehner,
and Rosalynn M. Nazarian
68 Histiocytic and dendritic cell sarcomas. ......................... 702
Archana Shenoy and Louis P. Dehner
69 Intralymphatic histiocytosis and Melkersson–Rosenthal
syndrome. ..................................................................... 708
Andrea P. Moy, Louis P. Dehner, and Rosalynn M. Nazarian
Part XII
Lymphoid Proliferations of Special Sites/Special
Populations 717
70 Oral lymphoproliferative disorders. ................................ 717
Kristin K. McNamara
71 Ocular lymphoproliferative disorders.............................. 751
Carolina M. Gentile and Paola de la Iglesia Niveyro
72 Cutaneous hematolymphoid proliferations in children. ... 770
Julia Scarisbrick, Louis P. Dehner, and Alejandro A. Gru
73 Alopecia in lymphoproliferative disorders....................... 820
Allen F. Shih, Ali Al-Haseni, and Lynne J. Goldberg
74 Cutaneous adverse reactions to chemotherapeutic
agents........................................................................... 834
Jacob Nosewicz, Brittany O. Dulmage, Jose A. Plaza,
and Benjamin H. Kaffenberger
75 Cutaneous adverse reactions to immunotherapy............ 867
Kelsey Nusbaum, Abraham Korman, Catherine G. Chung,
Benjamin H. Kaffenberger, and Brittany O. Dulmage
Part XIII
Cutaneous Manifestations Associated With
Hematologic Malignancy 872
76 Sweet and histiocytoid sweet syndrome. ....................... 872
Jacqueline M. Junkins-Hopkins and Viktoryia Kazlouskaya
77 Wells syndrome (eosinophilic cellulitis). ......................... 883
Melinda Jen and Adam I. Rubin
78 Vasculitis....................................................................... 887
Alejandro A. Gru
79 Paraneoplastic pemphigus............................................. 897
Katherine France, Milda Chmieliauskaite,
and Faizan Alawi
80 Cryoglobulinemia........................................................... 903
Alejandro A. Gru
81 Granulomatous reactions............................................... 910
Zoe O. Brown-Joel and Karolyn A. Wanat
82 Pyoderma gangrenosum................................................ 914
Campbell L. Stewart and Roberto Novoa
83 Schnitzler syndrome...................................................... 917
Viktoryia Kazlouskaya and Jacqueline M. Junkins-Hopkins
Index..................................................................................... 921