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This book presents the current state of knowledge regarding the ability of Helicobacter pylori to colonize the gastrointestinal tract, the global epidemiology of H. pylori infection, transmission routes, the pathophysiology of H. pylori-related gastroduodenal and other diseases, diagnosis and treatment methods, guidelines for eradication, antibiotic resistance, the reinfection and recrudescence rate after H. pylori eradication, the effect of H. pylori and its eradication on the gastric microbiota and animal models of H. pylori or related Helicobacter infection. The aim is to equip readers around the world with the understanding required in order to implement effective methods of H. pylori eradication and to enhance clinical outcomes for patients. In addition, readers can understand the interaction between H. pylori and other gut microbiota during chronic infection and after H. pylori eradication. The text is clearly written and is complemented by many helpful illustrations. This book will be a great asset in clinical practice for all practitioners who are involved in caring for patients with H. pylori-related diseases or have an interest in the subject. It will also be a useful source of information for medical students and for intelligent laypeople seeking information on H. pylori.
Pages i-xi
Front Matter
Pages 1-1
Prevalence and Transmission Routes of H. pylori
Pages 3-21
Front Matter
Pages 23-23
Gastric Colonization by H. pylori
Pages 25-37
Immunological Reactions on H. pylori Infection
Pages 39-59
Change of Acid Secretions, Ghrelin, and Leptin, by H. pylori
Pages 61-87
H. pylori Virulence Factors: Toxins (CagA, VacA, DupA, OipA, IceA)
Pages 89-102
H. pylori Virulence Factors: Genetic Polymorphism and Disease
Pages 103-120
Host Factor: Genetic Polymorphism
Pages 121-131
Front Matter
Pages 133-133
Pages 135-141
Histopathologic Diagnosis of H. pylori Infection and Associated Gastric Diseases
Pages 143-152
Pages 153-160
Pages 161-170
Pages 171-175
Pages 177-184
Specific Conditions: Diagnosis of H. pylori Infection in Case of Upper Gastrointestinal Bleeding
Pages 185-190
Diagnosis of H. pylori Infection After Gastric Surgery
Pages 191-201
Front Matter
Pages 203-203
Symptoms of Acute and Chronic H. pylori Infection
Pages 205-213
Front Matter
Pages 215-215
Synopsis of H. pylori-Associated Diseases
Pages 217-228
Atrophic Gastritis and Intestinal Metaplasia
Pages 229-251
Pages 253-267
Pages 269-280
Gastric Extranodal Marginal Zone B-Cell Lymphoma of MALT
Pages 281-292
Gastric Cancer: Synopsis and Epidemiology of Gastric Cancer
Pages 293-300
Pages 301-306
Gastric Cancer: Epigenetic Mechanisms: Aberrant DNA Methylation and Dysregulation of MicroRNA
Pages 307-319
Gastric Cancer: H. pylori and Macrophage Migration Inhibitory Factor
Pages 321-326
Gastric Cancer: Epithelial-Mesenchymal Transition
Pages 327-345
Gastric Cancer: ABO Blood Type
Pages 347-364
Gastric Cancer: First Relatives of Gastric Cancer
Pages 365-379
H. pylori Infection-Negative Gastric Cancer
Pages 381-388
Gastroesophageal Reflux Disease
Pages 389-393
NSAID-Induced Gastropathy and H. pylori Infection
Pages 395-402
Extraintestinal Manifestations of H. pylori Infection: H. pylori-Associated Iron Deficiency Anemia
Pages 403-413
Extraintestinal Manifestations of H. pylori Infection: Idiopathic Thrombocytopenic Purpura
Pages 415-420
Extraintestinal Manifestations of H. pylori Infection: Heart Disease
Pages 421-437
Extraintestinal Manifestations of H. pylori Infection: Asthma and Allergic Disorders
Pages 439-445
Extragastric Manifestations of H. pylori Infection: Lower GI Disorders
Pages 447-456
Extraintestinal Manifestations of H. pylori Infection: Neurologic Disease
Pages 457-472
Front Matter
Pages 473-473
Synopsis of Antimicrobial Resistance
Pages 475-483
Pages 485-495
Pages 497-506
Pages 507-516
Pages 517-526
Front Matter
Pages 527-527
Synopsis of Antibiotic Treatment
Pages 529-539
Pages 541-552
Pages 553-562
Pages 563-567
Concomitant Therapy and Hybrid Therapy
Pages 569-574
Tailored Therapy Based on Antibiotic Resistance
Pages 575-586
Fluoroquinolone and Rifabutin-Containing Therapy
Pages 587-594
Pages 595-606
Pages 607-615
Pages 617-624
Recrudescence and Reinfection After H. pylori Eradication Treatment
Pages 625-631
Front Matter
Pages 633-633
Pages 635-639
Atrophic Gastritis and Intestinal Metaplasia
Pages 641-659
Primary Prevention of Gastric Cancer
Pages 661-669
Secondary Prevention of Gastric Cancer After Endoscopic or Surgical Treatment
Pages 671-683
Pages 685-698
Front Matter
Pages 699-699
The Effect of H. pylori Infection on the Gastric Microbiota
Pages 701-723
The Effect of H. pylori Eradication on the Gastric Microbiota
Pages 725-742
Front Matter
Pages 743-743
Animal Models of H. pylori Infection
Pages 745-755
Pages 757-767
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