Table of Contents

Part 1: Cellular and Molecular Basis for Heart Failure
A Brief Primer on the Development of the Heart
Serge Gregoire and Sean Wu
The Genetics of Dilated and Hypertrophic Cardiomyopathies
Calum Macrae
Molecular Signaling Networks Underlying Cardiac Hypertrophy and Failure
Gerald W Dorn II MD
Excitation-Contraction Coupling in the Normal and Failing Heart
Mattew Coggins, Bernhard Haring, Federica del Monte
Myocardial energetics and cellular metabolism in the failing heart
Joanne S. Ingwall
Animal Models of Heart Failure
William Carlson

Part II: Pathophysiology of Heart Failure
Ventricular Remodeling and Secondary Valvular Dysfunction in Heart Failure Progression
Kibar Yared, Judy Hung
Neurohormonal and Cytokine Activation in Heart Failure
Dennis McNamara
Cardiomyopathies in the Adult
Richard Rodeheffer
Water and Salt: the cardiorenal syndrome
Maria Rosa Costanzo

Part III: The Demographics, Diagnosis and Monitoring of Heart Failure:
The Clinical Syndrome of Heart Failure
Thomas DiSalvo, Jordon Shin
Clinical Profiles and Bedside Assessment
Lynne Warner Stevenson
Prognosis in Heart Failure
J. Susie Woo, Wayne C. Levy,
Biomarkers in Heart Failure
Ravi V. Shah, MD and Thomas J. Wang
Noninvasive Imaging Modalities for the Evaluation of Heart Failure
Kimberly A. Parks and Malissa J. Wood
Role of Invasive Monitoring in Heart Failure: Pulmonary Artery Catheters in the Post-ESCAPE Era
W. H. Wilson Tang, Gary S. Francis

Part IV: The Medical Treatment of Clinical Heart Failure
Conventional Therapy of Chronic Heart Failure: Diuretics, Vasodilators, and Digoxin
G. William Dec, MD
Conventional Therapy of Chronic Heart Failure: Beta-Adrenergic Blockers
G. William Dec
Angiotensin Receptor Blockers for Heart Failure
George V. Moukarbel
Anticoagulation in Systolic Heart Failure
Ronald Freudenberger
Role of Mineralocorticoid Antagonists in Patients with Heart Failure
Mara Giattina, Flora Sam
Treatment of Heart Failure with Preserved Ejection Fraction
Barry A. Borlaug
Cardiac Resynchronization Therapy
William T. Abraham, MD
Management of Atrial and Ventricular Arrhythmias in Heart Failure
Usha Tedrow, William G. Stevenson
Ultrafiltration for the management of volume overload
Bradley A. Bart
Heart Failure and Palliative Care
Joshua Hauser, Robert Bonow

Part V: Molecular and Biologic Therapies
Gene Therapy for Heart Failure
Stefan Janssens