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Introduction
Pages 3-9
This book describes the most recent insights into heart failure and the role played by autonomic nervous system pathophysiology in it, discussing the therapeutic implications. While current therapeutic approaches are able to control the effects of excessive adrenergic activation in heart failure syndrome, the underlying abnormalities of adrenergic control remain unaltered and can still cause progression to unmanageable end-stage heart failure. New therapeutic pathways are therefore being explored with a view to developing interventions that can directly modulate adrenergic over-activity and restore a more appropriate balance in neural control of the cardiovascular system. The book opens by examining current heart failure therapies. Advances in our understanding of autonomic regulation/dysregulation in heart failure are then discussed in detail, in the context of the search for more effective therapies. A concluding section addresses the role of autonomic nervous system denervation in heart failure. The authors are top scientists from leading research centers.
Introduction
Pages 3-9
Therapies in Heart Failure, Tomorrow May Be Too Late
Pages 11-23
Atrial Fibrillation, Heart Failure, and the Autonomic Nervous System
Pages 25-41
Current Therapies for Ventricular Tachycardia: Are there Autonomic Implications of the Arrhythmogenic Substrate?
Pages 43-60
“The Autonomic Nervous System Symphony Orchestra”: Pathophysiology of Autonomic Nervous System and Analysis of Activity Frequencies
Pages 63-72
Autonomic Pathophysiology After Myocardial Infarction Falling into Heart Failure
Pages 73-85
Cardiovascular Serenade: Listening to the Heart
Pages 87-100
Whispering During Sleep: Autonomic Signaling During Sleep, Sleep Apnea, and Sudden Death
Pages 101-113
Cerebral Aging: Implications for the Heart Autonomic Nervous System Regulation
Pages 115-127
The Autonomic Cardiorenal Crosstalk: Pathophysiology and Implications for Heart Failure Management
Pages 131-164
Vagal Stimulation in Heart Failure: An Anti-inflammatory Intervention?
Pages 165-182
Baroreflex Activation Therapy in Heart Failure
Pages 183-197
Renal Reflexes and Denervation in Heart Failure
Pages 199-213
Back to the Future
Pages 215-216
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