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This volume is a practical guide of theranostics using intraoperative fluorescence imaging technology, as an all-out effort by the Japanese Society for Fluorescence Guided Surgery. It describes the various approaches the technique is being used such as vascular imaging, identification of lymphatic vessels by intratissue injection, lymph node imaging, and imaging for identification of anatomical structures. The book is organized into three major parts and the first one delivers the basics, introducing the use of the technology in clinical settings and initial setups. Next comes the description of clinical applications where chapters illustrate perfusion assessment, cancer localization, anatomy visualization, and lymph nodes/ducts mapping. Each chapter is devoted to the specific surgical field and disease areas, presenting images and videos of case studies. The last part presents some upcoming techniques for treatments. The Editor and the authors wish the ideas presented here will be hints to bridge the knowledge between surgeons and basic researchers for further innovation and practicality. It is important to stay up-to-date since intraoperative fluorescence imaging has been applied to clinical settings in various surgical fields and at the same time, novel techniques improving the efficacy of the technology have also been developed actively.
Fluorescence-Guided Surgery – From Lab to Operation Room is recommended for surgeons, operating nurses, medical experts, basic researchers and, industry engineers worldwide beyond boundaries of specialties. Edited and written by experts of The Japanese Society for Fluorescence-Guided Surgery, those who are the founders of the technology, it describes the accurate development history and cutting-edge techniques based on the knowledge accumulated over the years.
Pages i-xix
Front Matter
Pages 1-1
Clinically Available Fluorescent Reagents
Pages 3-6
Indocyanine Green Fluorescence Imaging System for Open Surgery
Pages 7-12
Indocyanine Green Fluorescence Imaging System for Endoscopic and Robot-Assisted Surgeries
Pages 13-17
5-Aminolevulinic Acid Fluorescence Imaging System
Pages 19-23
How to Introduce Fluorescence Imaging to the Operating Room
Pages 25-27
Recording of Intraoperative Fluorescence Imaging
Pages 29-31
Pages 33-36
Front Matter
Pages 37-37
Pages 39-40
Pages 41-45
Cerebral Angiography (Cerebral Aneurysm)
Pages 47-54
Evaluation of Blood Perfusion in Skin Flaps
Pages 55-62
Evaluation of Blood Perfusion in the Upper Gastrointestinal Tract
Pages 63-68
Evaluation of Blood Perfusion in Colorectal Surgery
Pages 69-75
Perfusion Assessment in HBP Surgery and Liver Transplantation
Pages 77-83
Pages 85-89
Front Matter
Pages 91-91
Liver Cancer (Primary Liver Cancer, Metastatic Liver Cancer)
Pages 93-99
Lung Cancer (Marking the Tumor Site)
Pages 101-110
Gastric Cancer (Primary Tumor, Peritoneal Dissemination)
Pages 111-116
Pages 117-125
Pages 127-133
Front Matter
Pages 135-135
Pages 137-137
Identification of Sentinel Lymph Nodes in Breast Cancer Surgery
Pages 139-143
Identification of Sentinel Lymph Nodes in Gastric Cancer Surgery
Pages 145-151
Identification of Sentinel Lymph Nodes in Colorectal Cancer Surgery
Pages 153-157
Identification of Sentinel Lymph Nodes in Gynecologic Surgery
Pages 159-164
Lymphography and Evaluation of Lymphedema
Pages 165-172
Front Matter
Pages 173-173
Imaging of the Bile Ducts (Fluorescence Cholangiography)
Pages 175-182
Pages 183-193
Pages 195-201
Pages 203-210
Imaging of the Parathyroid Gland
Pages 211-216
Front Matter
Pages 217-217
Pages 219-229
Development of a New Imaging System
Pages 231-236
Development of a New Operating Room That Integrates Imaging Information
Pages 237-245
Therapeutic Applications: Photodynamic Therapy Using Porphyrin Compounds
Pages 247-251
Application to Therapy (2): Photoimmunotherapy Using a Near-Infrared Fluorescent Probe
Pages 253-262
Pages 263-263
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