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Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. Updated material includes inflammation focusing in particular on chorioamnionitis and fetal brain injury; genetic brain injury; and expanded sections on cholestasis, diabetes, and thyroid disease. An updated, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.
	Part I. Epidemiology, Pathophysiology, and Pathogenesis of Fetal and Neonatal Brain Injury:
	1. Neonatal encephalopathy: epidemiology and overview
	2. Neuronal cell death mechanisms relevant to humans: rethinking modeling neonatal hypoxic-ischemic encephalopathy
	3. Cellular and molecular biology of hypoxic-ischemic encephalopathy
	4. The pathogenesis of preterm brain injury
	Part II. Pregnancy, Labor, and Delivery Complications Causing Brain Injury:
	5. Prematurity and complications of labor and delivery
	6. Risks and complications of multiple gestation
	7. Intrauterine growth restriction
	8. Maternal diseases that affect fetal and neonatal neurodevelopment
	9. Obstetrical conditions and practices that affect the fetus and newborn
	10. Fetal and neonatal injury as a consequence of maternal substance abuse
	11. Hypertensive disorders of pregnancy
	12. Complications of labour and delivery
	13. Fetal responses to asphyxia
	14. Antepartum evaluation of fetal well-being
	15. Intrapartum evaluation of the fetus
	Part III. Diagnosis of the Infant with Brain Injury:
	16. Clinical manifestations of hypoxic-ischemic encephalopathy
	17. The use of EEG and aEEG in assessing the term and preterm brain
	18. Neuroimaging in the evaluation of pattern and timing of fetal and neonatal brain abnormalities
	19. Light-based assessment of the brain
	20. Placental pathology and the etiology of fetal and neonatal brain injury
	21. Timing perinatal hypoxic-ischemic brain injury
	Part IV. Specific Conditions Associated with Fetal and Neonatal Brain Injury:
	22. Congenital malformations of the brain
	23. Neurogenetic disorders of the brain
	24. Hemorrhagic lesions of the central nervous system
	25. Neonatal stroke
	26. Neurodevelopmental consequences of neonatal hypoglycemia
	27. Hyperbilirubinemia and kernicterus
	28. Polycythemia and fetal–maternal bleeding
	29. Hydrops fetalis
	30. Bacterial sepsis in the neonate
	31. Neonatal bacterial meningitis
	32. Neurological sequelae of congenital and perinatal infections
	33. Neurological complications of perinatal human immunodeficiency virus infection
	34. Inborn errors of metabolism and single gene disorders with features of neonatal encephalopathy
	35. Acidosis and alkalosis
	36. Persistent pulmonary hypertension of the newborn
	37. Pediatric cardiac surgery: relevance to fetal and neonatal brain injury
	38. Neonatal resuscitation: immediate management
	39. Improving performance, reducing error, and minimizing risk in the delivery room
	40. Extended management following resuscitation
	41. Endogenous and exogenous neuroprotective mechanisms after hypoxic-ischemic injury
	42. Neonatal seizures: evaluation, treatment, and prognosis
	43. Nutritional support of the asphyxiated infant
	44. Early outcomes after extremely preterm birth
	45. Cerebral palsy: advances in definition, classification, management and outcome
	46. Neurodevelopmental and neurobehavioral outcomes of prematurity: cognition, language, academic skills, and behavioral and emotional profiles
	47. Neurocognitive outcomes in term infants with neonatal encephalopathy
	48. Neonatal neuroethics
	49. Medicolegal issues in perinatal brain injury.
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