Section I. Neuroanatomy
	Chapter 1. Neuroanatomy
	- 
		Introduction
 
	- 
		Embryological Differentiation of Different Parts of Brain
 
	- 
		Anatomy of Brain
 
	- 
		Vascular Supply of the Brain
 
	- 
		The Meninges and Cerebrospinal Fluid
 
	Chapter 2. Neuroembryology
	- 
		Formation of Zygote
 
	- 
		Formation of Blastocyst
 
	- 
		Formation of Embryonic or Germ Disc
 
	- 
		Formation of Definitive Notochord
 
	- 
		Development of Nervous System
 
	Chapter 3. Blood-Brain Barrier
	- 
		Introduction
 
	- 
		Permeability at the Blood-Brain Barrier
 
	- 
		Cellular and Molecular Effects of Anesthetics on the Blood-Brain Barrier
 
	- 
		Clinical and Experimental Implications of Anesthetics on the Blood-Brain Barrier
 
	- 
		Conclusion
 
	Section II. Neurophysiology
	Chapter 4. Neurophysiology
	- 
		Intracranial Pressure
 
	- 
		Normal Intracranial Pressure
 
	- 
		Cerebral Compliance
 
	- 
		Importance of Intracranial Pressure
 
	- 
		Summary
 
	- 
		Cerebral Blood Flow
 
	- 
		Vascular Anatomy
 
	- 
		Summary
 
	- 
		Brain Metabolism
 
	- 
		Normal Cerebral Metabolism
 
	- 
		Summary
 
	- 
		Cerebrospinal Fluid
 
	- 
		Ventricular System
 
	- 
		Summary
 
	- 
		The Spinal Cord
 
	- 
		Anatomy
 
	- 
		Organization of the Spinal Cord
 
	- 
		Summary
 
	Chapter 5. Brain Protection in Neurosurgery
	- 
		Introduction
 
	- 
		Nonpharmacological Strategies
 
	- 
		Mild Hypothermia
 
	- 
		Blood Pressure Control
 
	- 
		Induced Arterial Hypertension
 
	- 
		Normoglycemia
 
	- 
		Target Hemoglobin Concentration
 
	- 
		Pharmacological Strategies
 
	- 
		Nonanesthetic Agents
 
	- 
		Anesthetic Agents
 
	- 
		Conclusion
 
	Section III. Neuropharmacology
	Chapter 6. Neuropharmacology
	- 
		Anesthetic Drugs and Sedatives
 
	- 
		Intravenous Anesthetic Agents
 
	- 
		Inhalational Anesthetic Agents
 
	- 
		Neuromuscular Blocking Agents
 
	- 
		Local Anesthetic Agents
 
	- 
		Miscellaneous Drugs
 
	- 
		Future Directions in Neuropharmacology
 
	- 
		Conclusion
 
	Chapter 7. Anesthetic Agents: Neurotoxics or Neuroprotectives?
	- 
		Introduction
 
	- 
		Pharmacological Considerations
 
	- 
		Anesthesia Practice: Clinical Outcomes
 
	- 
		Anesthesia and Fragile Brain
 
	- 
		Conclusion
 
	- 
		Abbreviations
 
	Section IV. Neuromonitoring
	Chapter 8. Neuromonitoring
	- 
		Introduction
 
	- 
		Cerebral Blood Flow
 
	- 
		Transcranial Sonography
 
	- 
		Thermal Diffusion Flowmetry
 
	- 
		Laser Doppler Flowmetry
 
	- 
		Intra-Arterial 133Xenon
 
	- 
		CT Perfusion
 
	- 
		Xenon Enhanced CT
 
	- 
		Positron Emission Tomography
 
	- 
		Single Photon Emission Computed Tomography
 
	- 
		Magnetic Resonance Imaging
 
	- 
		Intracranial Pressure
 
	- 
		Electroencephalogram
 
	- 
		Evoked Potential Monitoring
 
	- 
		Motor Evoked Potentials
 
	- 
		Depth of Anesthesia
 
	- 
		Cerebral Oxygenation Monitoring
 
	- 
		Jugular Venous Oximetry
 
	- 
		Regional Cerebral Oximetry
 
	- 
		Brain Tissue Oxygen Monitoring
 
	- 
		Cerebral Microdialysis
 
	- 
		Conclusion
 
	Chapter 9. Multimodal Monitoring
	- 
		Introduction
 
	- 
		Temperature
 
	- 
		Oxygen Transport, Hemodynamics, and Brain Metabolism
 
	- 
		Intracranial Pressure Monitoring
 
	- 
		Electroencephalography and Depth of Anesthesia Monitoring
 
	- 
		Miscellaneous
 
	- 
		Integration of Information and Decision-Helping Systems
 
	- 
		Clinical Pearls
 
	Section V. Positions in Neurosurgery
	Chapter 10. Positioning in Neurosurgery
	- 
		Introduction
 
	- 
		Historical Background
 
	- 
		Principles of Positioning
 
	- 
		The Conduct of Positioning
 
	- 
		Surgical Approach for Craniotomies
 
	- 
		Positioning for Craniotomy
 
	- 
		Positions Used for Craniotomies
 
	- 
		Surgical Approach for Procedures of the Spine
 
	- 
		Conclusion
 
	- 
		Abbreviations
 
	Section VI. Preanesthetic Evaluation
	Chapter 11. Preanesthetic Evaluation of Neurosurgical Patients
	- 
		Introduction
 
	- 
		Preoperative Evaluation of Patient-Related Risk Factors
 
	- 
		Preoperative Evaluation of Specific Neurosurgical Conditions
 
	Section VII. Neurosurgery
	Chapter 12. Supratentorial Lesions
	- 
		Introduction
 
	- 
		Classification
 
	- 
		Pathophysiology and Clinical Correlations
 
	- 
		Clinical Features
 
	- 
		Neuroimaging
 
	- 
		Intraoperative Considerations: The Team Approach
 
	- 
		Anesthetic Management
 
	- 
		Intraoperative Management
 
	- 
		Emergence From Anesthesia
 
	- 
		Postoperative Management
 
	- 
		Awake Craniotomy
 
	- 
		Conclusions
 
	Chapter 13. Emergence From Anesthesia
	- 
		Introduction
 
	- 
		Neurophysiological Response During Emergence in Neurosurgical Patients
 
	- 
		Specific Perioperative Considerations
 
	- 
		Delayed Emergence and Arousal
 
	- 
		Complications
 
	- 
		Conclusion
 
	Chapter 14. Anesthesia for Posterior Fossa Surgery
	- 
		Introduction
 
	- 
		Anatomy
 
	- 
		Clinical Presentation
 
	- 
		Perioperative Management of Patients for Posterior Fossa Surgery
 
	- 
		Venous Air Embolism
 
	- 
		Postoperative Management
 
	- 
		Complications
 
	- 
		Abbreviations
 
	Chapter 15. Transesophageal Echocardiography
	- 
		Introduction
 
	- 
		Basics of Transesophageal Echocardiography
 
	- 
		Summary
 
	Chapter 16. Anesthesia for Epilepsy Surgery
	- 
		Introduction
 
	- 
		Surgical Management of Epilepsy
 
	- 
		Types of Surgical Treatment
 
	- 
		Presurgical Evaluation
 
	- 
		Anesthesia for Epilepsy Surgery
 
	- 
		Effect of Anesthetic Agents in Patients With Epilepsy
 
	- 
		Antiepileptic Drug Interactions
 
	- 
		Preanesthetic Evaluation and Preparation
 
	- 
		Anesthetic Management of Preoperative Procedures
 
	- 
		Anesthesia for Intracranial Electrode Insertion
 
	- 
		Anesthetic Management of Resection of Seizure Focus
 
	- 
		Awake Craniotomy
 
	- 
		Resection of Epileptogenic Focus Under General Anesthesia
 
	- 
		Neurostimulation for Drug-Resistant Epilepsy
 
	- 
		Anesthetic Management of the Patient With Epilepsy for Incidental Surgery
 
	- 
		Abbreviations
 
	Chapter 17. Refractory Status Epilepticus
	- 
		Introduction
 
	- 
		Epidemiology
 
	- 
		Classification
 
	- 
		Cause
 
	- 
		Pathophysiology
 
	- 
		Diagnosis
 
	- 
		Management
 
	- 
		Treatment
 
	- 
		Conclusions
 
	Chapter 18. Aneurysmal Subarachnoid Hemorrhage
	- 
		History
 
	- 
		Introduction
 
	- 
		Clinical Presentation and Diagnosis
 
	- 
		Grading of Subarachnoid Hemorrhage
 
	- 
		Initial Management Concerns in Neurocritical Care Unit
 
	- 
		Timing of Surgery
 
	- 
		Clipping or Coiling
 
	- 
		Evaluation of a Patient With Subarachnoid Hemorrhage for Anesthesia
 
	- 
		Anesthetic Management
 
	- 
		Temporary Clipping and Brain Protection Strategy
 
	- 
		Intraoperative Aneurysm Rupture
 
	- 
		Giant Aneurysms and Circulatory Arrest
 
	- 
		Endovascular Management for Aneurysm Ablation
 
	- 
		Postoperative Management of Patients
 
	- 
		Conclusion
 
	Chapter 19. Circulatory Arrest
	- 
		Introduction
 
	- 
		Deep Hypothermic Circulatory Arrest
 
	- 
		Anesthesia Management
 
	- 
		Complications
 
	- 
		Adenosine-Induced Circulatory Arrest
 
	- 
		Anesthesia Considerations
 
	- 
		Complications
 
	- 
		Summary
 
	Chapter 20. Cerebrovascular Disease
	- 
		Intracerebral Hemorrhage
 
	- 
		Incidence and Risk Factors
 
	- 
		Imaging
 
	- 
		Clinical Presentation
 
	- 
		Management of Intracerebral Hemorrhage
 
	- 
		Arteriovenous Malformations
 
	- 
		Cause and Incidence
 
	- 
		Natural History
 
	- 
		Pathophysiologic Effects and Clinical Presentation
 
	- 
		Grading of Arteriovenous Malformations
 
	- 
		Imaging
 
	- 
		Cerebral Hemodynamics in Arteriovenous Malformation
 
	- 
		Management
 
	- 
		Surgical Resection of Arteriovenous Malformation
 
	- 
		Anesthetic Considerations for Resection of Arteriovenous Malformation
 
	- 
		Postoperative Management
 
	- 
		Anesthetic Considerations for Arteriovenous Malformation Embolization
 
	- 
		Complications During Arteriovenous Malformation Embolization
 
	- 
		Pediatric Arteriovenous Malformations
 
	- 
		Pregnancy and Arteriovenous Malformations
 
	- 
		Vein of Galen Aneurysmal Malformations
 
	- 
		Dural Arteriovenous Fistula
 
	- 
		Clinical Presentation
 
	- 
		Management
 
	- 
		Carotid Endarterectomy
 
	- 
		Preoperative Evaluation
 
	- 
		Management of Carotid Artery Disease
 
	- 
		Monitoring
 
	- 
		Intraoperative Management
 
	- 
		Postoperative Complications and Outcomes
 
	- 
		Coronary Angioplasty and Stenting
 
	- 
		Moyamoya Disease
 
	- 
		Management of Moyamoya Disease
 
	Chapter 21. Flow Arrest in Cerebrovascular Surgery
	- 
		Deep Hypothermic Circulatory Arrest
 
	- 
		Adenosine-Assisted Cerebral Blood Flow Arrest
 
	- 
		Rapid Ventricular Pacing-Assisted Cerebral Blood Flow Arrest
 
	Chapter 22. Neuroendocrine Lesions
	- 
		Hypothalamic-Pituitary-Adrenal Axis Evaluation
 
	- 
		Neuroendocrine Response Related to Anesthesia and Surgery
 
	- 
		Pituitary Gland Adenomas
 
	- 
		Physiology of Pituitary Gland
 
	- 
		Endocrine Diseases
 
	- 
		Nonfunctioning Tumors
 
	- 
		Intraoperative Considerations
 
	- 
		Advantages of Endoscopic Endonasal Approach
 
	- 
		Relative Contraindications to Transsphenoidal Approach
 
	- 
		Intraoperative Issues
 
	- 
		Disorder of Water and Electrolytes
 
	Chapter 23. Pituitary Apoplexy
	- 
		Clinical Features
 
	- 
		Management
 
	Chapter 24. Spinal Surgery
	- 
		Introduction
 
	- 
		Spine
 
	- 
		Types of Spine Surgeries
 
	- 
		Surgical Approaches to the Spine
 
	- 
		Common Spine Disorders
 
	- 
		Imaging in Spine Lesions
 
	- 
		Positioning for Spine Surgeries
 
	- 
		Neurophysiological Intraoperative Monitoring During Spine Surgeries
 
	- 
		Preanesthetic Assessment and Optimization
 
	- 
		Anesthesia Management
 
	- 
		Postoperative Management
 
	- 
		Special Considerations
 
	- 
		Conclusion
 
	Chapter 25. Postoperative Visual Loss
	- 
		Introduction
 
	- 
		Central Retinal Artery Occlusion
 
	- 
		Ischemic Optic Neuropathy
 
	- 
		Cortical Blindness
 
	- 
		Recent Advances
 
	- 
		Conclusion
 
	Chapter 26. Neuroendoscopy
	- 
		Introduction
 
	- 
		Anesthetic Goals and Management
 
	- 
		Anesthetic Management of Specific Neuroendoscopic Procedures
 
	- 
		Advances in Neuroendoscopy
 
	- 
		Conclusion
 
	- 
		Clinical Pearls
 
	Chapter 27. Pressure Inside the Neuroendoscope
	- 
		Introduction
 
	- 
		Indications and Procedures
 
	- 
		How Do Neurosurgeons Perform an Intraventricular Endoscopic Procedure?
 
	- 
		Anesthetic Procedure: What to Take Into Account?
 
	- 
		Perioperative Complications
 
	- 
		Conclusion
 
	Chapter 28. Anesthesia for Functional Neurosurgery
	- 
		Introduction
 
	- 
		Procedure
 
	- 
		Anesthetic Consideration
 
	- 
		Anesthetic Techniques
 
	- 
		Complications
 
	- 
		Anesthesia in Patients With Deep Brain Stimulator In Situ
 
	- 
		Conclusion
 
	Chapter 29. Awake Craniotomy
	- 
		Introduction
 
	- 
		Patient Selection
 
	- 
		Awake Craniotomy for Tumor Surgery
 
	- 
		Awake Craniotomy for Epilepsy
 
	- 
		Conclusion
 
	Section VIII. Neuroradiology
	Chapter 30. Anesthesia for Neuroradiology
	- 
		Introduction
 
	- 
		Issues Relating to Anesthesia Care in Neuroradiology
 
	- 
		Anesthesia for Computed Tomographic Study
 
	- 
		Anesthesia for Magnetic Resonance Imaging Study
 
	- 
		Anesthesia for Diagnostic Angiography
 
	- 
		Anesthetic Management of Endovascular Coiling
 
	- 
		Anesthetic Management of Endovascular Embolization of Arteriovenous Malformation, Arteriovenous Fistula, and Vein of Galen Malformation
 
	- 
		Anesthesia for Stroke Interventions
 
	- 
		Issues Related to Radiation During Neurointervention
 
	- 
		Anesthesia for Stereotactic Radiosurgery
 
	- 
		Pregnancy and Neuroradiology
 
	- 
		Clinical Pearls
 
	Chapter 31. Magnetic Resonance Imaging: Anesthetic Implications
	- 
		Introduction: The Road From X-Ray to Magnetic Resonance Imaging
 
	- 
		Principles of Nuclear Magnetic Resonance and Magnetic Resonance Imaging
 
	- 
		Various Types of Signals Recorded
 
	- 
		Hazards Related to Magnetic Resonance Imaging
 
	- 
		Magnetic Resonance Imaging Safety: General Considerations
 
	- 
		Magnetic Resonance Imaging Safety: Management of Cardiac Implantable Electronic Devices and Other Implantable Devices
 
	- 
		Anesthesia for Magnetic Resonance Imaging
 
	- 
		Research Applications/Emerging Clinical Applications of Magnetic Resonance Imaging
 
	Section IX. Neurotrauma
	Chapter 32. Neurotrauma
	- 
		Traumatic Brain Injury
 
	- 
		Definition
 
	- 
		Epidemiology
 
	- 
		Classification of Traumatic Brain Injury
 
	- 
		Physiologic Response to Brain Injury
 
	- 
		Neuroimaging
 
	- 
		Severity of Traumatic Brain Injury
 
	- 
		Management of Traumatic Brain Injury
 
	- 
		Outcome
 
	- 
		Emerging Treatment Modalities
 
	- 
		Conclusion
 
	- 
		Spine and Spinal Cord Trauma
 
	- 
		Epidemiology
 
	- 
		Classification of Spinal Injury
 
	- 
		Pathophysiology of Spinal Cord Trauma
 
	- 
		Systemic Complications of Spinal Cord Injuries
 
	- 
		Management of Spine and Spinal Cord Injury
 
	- 
		Emerging Treatment Modalities
 
	Chapter 33. Biomarkers in Traumatic Brain Injury
	Section X. Neurointensive Care
	Chapter 34. Neurological Critical Care
	- 
		Introduction
 
	- 
		History of Neurocritical Care
 
	- 
		Design of a Neurocritical Care Unit
 
	- 
		Clinical Conditions Requiring Admission to Neurocritical Care Unit
 
	- 
		Justification for Neurological Critical Care Units
 
	- 
		Pathophysiological Issues in Neurological Critical Care
 
	- 
		Management of Patients in a Neurological Intensive Care Unit
 
	- 
		Management of General Systemic Physiology
 
	- 
		Specific Therapeutic Issues in Individual Clinical Conditions
 
	- 
		Advanced Neuromonitoring
 
	- 
		Outcomes of Neurological Intensive Care Unit
 
	- 
		End-of-Life Issues in Neurological Critical Care
 
	- 
		Clinical Pearls
 
	Chapter 35. Antibiotics: Prophylactic and Therapeutics
	- 
		Introduction
 
	- 
		Principles of Antimicrobial Therapy in Neurosurgery
 
	- 
		Treatment of Central Nervous System Infections in the Neurosurgical Patient
 
	- 
		Antimicrobial Prophylaxis in Neurosurgery
 
	Section XI. Special Considerations
	Chapter 36. Pediatric Neuroanesthesia
	- 
		Overview
 
	- 
		Pediatric Neurophysiology
 
	- 
		General Principles of Pediatric Neuroanesthesia
 
	- 
		Intraoperative Management
 
	- 
		Postoperative Considerations
 
	- 
		Management of Specific Conditions
 
	- 
		Conclusion
 
	Chapter 37. Fluid and Blood Transfusion in Pediatric Neurosurgery
	- 
		Introduction
 
	- 
		Fluid and Electrolyte Choices
 
	- 
		Type of Fluids for Perioperative Administration in Pediatric Patients
 
	- 
		Fluid Management in Pediatric Neurosurgery
 
	- 
		Osmotherapy
 
	- 
		Fluid and Electrolyte Disturbances in Pediatric Neurosurgery
 
	- 
		Blood Transfusion
 
	- 
		Blood Components
 
	- 
		Special Situations
 
	- 
		Epilepsy Surgery
 
	- 
		Scoliosis
 
	- 
		Conclusion
 
	Chapter 38. Geriatric Neuroanesthesia
	- 
		Introduction
 
	- 
		Implications of Surgical Stress and Anesthesia on the Elderly
 
	- 
		Neurosurgical Concerns Unique to the Elderly
 
	- 
		Conclusion
 
	Chapter 39. Postoperative Cognitive Dysfunction
	- 
		Introduction
 
	- 
		Definitions, Epidemiology, and Pathophysiology
 
	- 
		Risk Factors
 
	- 
		Prevention
 
	- 
		Screening Tools
 
	- 
		Treatment
 
	- 
		Outcome
 
	Chapter 40. Pregnancy
	- 
		Requirement of Neurosurgery During Pregnancy
 
	- 
		Physiological Alterations During Pregnancy
 
	- 
		Effect of Anesthetic Agents on Fetal Outcome
 
	- 
		Uteroplacental Drug Transfer and Neonatal Depression
 
	- 
		Timing and Method of Delivery
 
	- 
		Anesthetic Considerations During Pregnancy
 
	- 
		Induction: Rapid Sequence Versus Slow Neuroinduction
 
	- 
		Combined Cesarean Delivery and Neurosurgery
 
	- 
		Intracranial Pressure and Regional Anesthesia
 
	- 
		Postoperative Management
 
	- 
		Anesthesia for Interventional Neurosurgical Procedures
 
	Chapter 41. Cerebral Venous Thrombosis
	- 
		Definition
 
	- 
		Venous Anatomy
 
	- 
		Incidence of Cerebral Venous Thrombosis
 
	- 
		Risk Factors
 
	- 
		Pathophysiology
 
	- 
		Clinical Manifestations
 
	- 
		Diagnostic Evaluation
 
	- 
		Treatment
 
	- 
		Anesthetic Management
 
	- 
		Prognosis
 
	- 
		Conclusion
 
	Chapter 42. Neurosurgical Anesthesia in Patients With Coexisting Cardiac Disease
	- 
		Introduction
 
	- 
		Preoperative Evaluation
 
	- 
		Risk Stratification
 
	- 
		Perioperative Monitoring
 
	- 
		Ischemic Heart Disease
 
	- 
		Valvular Heart Disease
 
	- 
		Tumors of the Heart
 
	- 
		Congenital Heart Disease
 
	- 
		Hypertension
 
	- 
		Conclusion
 
	Chapter 43. Intraoperative Cardiopulmonary Resuscitation
	- 
		Introduction
 
	- 
		Incidence, Morbidity, and Mortality
 
	- 
		Survival From Intraoperative Cardiac Arrest
 
	- 
		Predictors
 
	- 
		Cause of Intraoperative Cardiac Arrest
 
	- 
		Cardiopulmonary Resuscitation Quality
 
	- 
		Cardiac Arrest and Cardiopulmonary Resuscitation in Neurosurgical Patients
 
	- 
		Prognosis
 
	- 
		Conclusion
 
	Chapter 44. Coexisting Diabetes Mellitus in Neurosurgical Patients
	- 
		Introduction
 
	- 
		Incidence of Diabetes Mellitus
 
	- 
		Glycemic Indices
 
	- 
		Modes of Glucose Measurement
 
	- 
		Pathophysiology of Diabetes Mellitus
 
	- 
		Cerebral Glucose Metabolism
 
	- 
		Hyperglycemia and the Brain
 
	- 
		Hyperglycemic Neuropathy
 
	- 
		Diabetic Dysautonomia
 
	- 
		Hypoglycemia and the Brain
 
	- 
		Evidence of Glycemic Control in Important Neurosurgical Subsets
 
	- 
		Traumatic Brain Injury
 
	- 
		Subarachnoid Hemorrhage
 
	- 
		Cerebrovascular Accidents
 
	- 
		Tumor Surgery
 
	- 
		Spine Surgery
 
	- 
		Blood Sugar Management in Perioperative Period and Neurocritical Care
 
	- 
		Intraoperative Management
 
	- 
		Anesthetic Management
 
	- 
		Postoperative Glycemic Management
 
	- 
		Blood Sugar Control in Emergency Neurosurgical Patient
 
	- 
		Blood Sugar Control in Intensive Care Setup
 
	- 
		Nutrition
 
	- 
		Conclusions
 
	- 
		Coexisting Hypertension in Neurosurgical Patients
 
	- 
		Physiology of Cerebral Circulation
 
	- 
		Pathophysiology of Arterial Hypertension
 
	- 
		Hypertension in Patients With Traumatic Brain Injury
 
	- 
		Perioperative Management
 
	- 
		Preoperative Evaluation
 
	- 
		Antihypertensive Drugs
 
	- 
		Intraoperative Management
 
	- 
		Monitoring
 
	- 
		Induction of Anesthesia
 
	- 
		Maintenance of Anesthesia
 
	- 
		Recovery From Anesthesia
 
	- 
		Postoperative Care
 
	- 
		Neurocritical Care
 
	- 
		Conclusion
 
	Chapter 45. Neuromuscular Disorders
	- 
		Introduction
 
	- 
		Myasthenia Gravis
 
	- 
		Myasthenic Crisis
 
	- 
		Lambert-Eaton Myasthenic Syndrome
 
	- 
		Guillain-Barré Syndrome
 
	- 
		Periodic Paralysis
 
	- 
		Myotonias
 
	- 
		Muscular Dystrophies
 
	- 
		Motor Neuron Diseases
 
	- 
		Multiple Sclerosis
 
	- 
		Parkinson’s Disease
 
	- 
		Alzheimer’s Disease
 
	- 
		Huntington’s Disease
 
	Chapter 46. Neuromuscular Electrical Stimulation in Critically Ill Patients
	- 
		Introduction
 
	- 
		Neuromuscular Electrical Stimulation: Basic Concepts and Practical Considerations
 
	- 
		Neuromuscular Electrical Stimulation in the Intensive Care Unit
 
	- 
		Contraindications and Adverse Effects
 
	- 
		Recommendations for the Use of Neuromuscular Electrical Stimulation in the Intensive Care Unit
 
	Chapter 47. Neurological Patients for Nonneurosurgeries
	- 
		Neurodegenerative Diseases
 
	- 
		Demyelinating Disease
 
	- 
		Neuromuscular Disease: Myasthenia Gravis
 
	- 
		Epilepsy
 
	- 
		Intracranial Tumors
 
	- 
		Traumatic Brain Injury
 
	Chapter 48. Anesthesia for Electroconvulsive Therapy
	- 
		Background
 
	- 
		Technique of Electroconvulsive Therapy
 
	- 
		Contraindications
 
	- 
		Preprocedure Management
 
	- 
		Anesthesia for Electroconvulsive Therapy
 
	- 
		Side Effects
 
	- 
		Special Conditions
 
	- 
		Conclusion
 
	Section XII. Fluids and Electrolyte Management
	Chapter 49. Fluids and Electrolyte Management
	- 
		Introduction
 
	- 
		Anatomy and Physiology
 
	- 
		Pathophysiology
 
	- 
		Definitions
 
	- 
		Choice of Fluids
 
	- 
		Hypertonic Fluids
 
	- 
		Isotonic Fluids
 
	- 
		Colloids
 
	- 
		Hypotonic Fluids
 
	- 
		Fluid Management
 
	- 
		Commonly Encountered Fluid Abnormalities
 
	- 
		Conclusion
 
	- 
		Clinical Pearls
 
	Chapter 50. Crystalloid and Colloid Fluids
	- 
		Crystalloid Fluids
 
	- 
		Colloid Fluids
 
	- 
		Which Fluid to Choose?
 
	- 
		Conclusions
 
	Section XIII. Pain Management
	Chapter 51. Pain Management
	- 
		Postcraniotomy Pain
 
	- 
		Incidence
 
	- 
		Anatomical and Physiological Basis of Pain Following Craniotomy
 
	- 
		Pain-Sensitive Structures of Cranium
 
	- 
		Pathogenesis of Postcraniotomy Pain
 
	- 
		Factors Affecting Postcraniotomy Pain
 
	- 
		Classification and Assessment of Postcraniotomy Pain
 
	- 
		Preemption of Pain
 
	- 
		Treatment of Acute Pain
 
	- 
		Postcraniotomy Pain Management in the Pediatric Population
 
	- 
		Conclusion
 
	- 
		Acute Pain Management After Spinal Surgery
 
	- 
		Pathophysiology
 
	- 
		Treatment Modalities for Acute Postoperative Spinal Pain
 
	- 
		Conclusion
 
	Section XIV. Brain Death and Ethical Issues
	Chapter 52. Brain Death and Ethical Issues in Neuroanesthesia Practice
	- 
		Part A: Brain Death
 
	- 
		Criteria for Diagnosing Death
 
	- 
		Need for Brain Death Diagnosis
 
	- 
		Rules Regulating Diagnosis of Brain Death
 
	- 
		Criteria for Certifying Brain Stem Death
 
	- 
		Pitfalls/Controversies
 
	- 
		Conclusion
 
	- 
		Appendix I
 
	- 
		Part B: Ethical Issues in Neuroanesthesia Practice
 
	- 
		Ethical Issues in Clinical Care
 
	- 
		Ethical Issues Related to Research
 
	- 
		Ethical Issues Related to Team Work
 
	- 
		Ethical Issues Related to Training
 
	- 
		Ethical Issues Related to Innovative Neurosurgery
 
	- 
		Conclusion
 
	Chapter 53. Organ Donation
	Section XV. Evidence-Based Practice
	Chapter 54. Evidence-Based Practice of Neuroanesthesia
	- 
		Introduction
 
	- 
		Evidence-Based Practice and Neuroanesthesia
 
	- 
		Evidence and the Brain Trauma Foundation Guidelines
 
	- 
		Unresolved Issues in the Practice of Neuroanesthesia
 
	- 
		Conclusion
 
	- 
		Clinical Pearls
 
	Chapter 55. Translational Research
	- 
		Introduction
 
	- 
		Definition
 
	- 
		In Neuroanesthesia
 
	- 
		Why Not Lead to Clinical
 
	- 
		To Be a Successful Translation
 
	- 
		Conclusion
 
	Section XVI. Recent Advances
	Chapter 56. Recent Advances in Neuroanesthesiology
	- 
		Introduction
 
	- 
		Endovascular Treatment of Stroke and Perioperative Stroke
 
	- 
		Indications for Deep Brain Stimulation
 
	- 
		Anesthetic Neurotoxicity
 
	- 
		Pre- and Postconditioning
 
	- 
		Brain Monitoring
 
	- 
		New Assays for Creutzfeldt-Jakob Disease
 
	Chapter 57. Stem Cell Therapy
	- 
		Hypothesis of Stem Cell Research
 
	- 
		Stem Cell
 
	- 
		Historical Background
 
	- 
		Types of Stem Cells
 
	- 
		Sources of Stem Cells
 
	- 
		Mesenchymal Stem Cells
 
	- 
		Stem Cells in Neurological Diseases
 
	- 
		Mode of Action of Stem Cell Therapy
 
	- 
		Ethical Issues
 
	- 
		Recent Advances
 
	Chapter 58. Pharmacogenomics
	- 
		Introduction
 
	- 
		Basic Genetic Principles
 
	- 
		Basic Pharmacologic Principles
 
	- 
		Anesthesia Contribution to the History of Pharmacogenomics
 
	- 
		Pharmacogenomics: Current Application to Clinical Anesthesia
 
	- 
		Conclusion
 
	Section XVII. Sterilization Techniques
	Chapter 59. Sterilization and Disinfection
	- 
		Background
 
	- 
		Recommendation of Preferred Methods for Various Medical Devices
 
	- 
		Recommendation for the Cleaning and Decontamination of Environmental Surfaces
 
	- 
		Recommendation for Blood Spill on the Surface
 
	- 
		Cleaning and Disinfection of Medical Instruments
 
	- 
		Cleaning and Reprocessing of Patient Care Equipment
 
	- 
		Reprocessing of Respiratory Apparatus and Endoscopes
 
	- 
		Reprocessing of Endoscopes
 
	- 
		Specific Issues
 
	- 
		Special Precaution for Inactivation of Creutzfeldt-Jakob Disease
 
	- 
		Health Care-Associated Infections
 
	- 
		Infections in Operating Rooms and Intensive Care Units
 
	- 
		Conclusion
 
	Chapter 60. Universal Precautions in the Intensive Care Unit
	- 
		Introduction
 
	- 
		Prophylactics of Health Care-Associated Infections in the Intensive Care Unit
 
	- 
		Early Diagnosis of Pathogens and Infection Complications in the Intensive Care Unit
 
	- 
		Rational Antibiotic Therapy
 
	- 
		Systemic Approach
 
	- 
		Conclusion
 
	Section XVIII. Palliative Care
	Chapter 61. Palliative Care to Neurological and Neurosurgical Patients
	Chapter 62. Quality of Life and Health-Related Issues
	- 
		Introduction
 
	- 
		Quality of Life and Health-Related Quality of Life
 
	- 
		Utility of Health-Related Quality of Life
 
	- 
		Tools for Measuring Health-Related Quality of Life
 
	- 
		Uses of Measuring Health-Related Quality of Life
 
	- 
		Health-Related Quality of Life in Relation to Neurosurgical/Neurological Conditions
 
	- 
		Conclusion
 
	Section XIX. Biostatistics
	Chapter 63. Biostatistics
	- 
		Introduction to Biostatistics
 
	- 
		Definition of Statistics
 
	- 
		Biostatistics and Its Applications
 
	- 
		Uses of Statistical Methods in Medical Sciences
 
	- 
		Some Basic Statistical Concepts
 
	- 
		Population and Sample
 
	- 
		Scale of Measurements
 
	- 
		Constant
 
	- 
		Variables
 
	- 
		Parameter and Statistic
 
	- 
		Ratio, Proportion, and Rate
 
	- 
		Statistical Inference
 
	- 
		Estimation
 
	- 
		Hypothesis Testing
 
	- 
		Steps in Hypothesis Testing or Testing the Statistical Significance
 
	- 
		Defining the Null and Alternative Hypotheses
 
	- 
		Calculating the Test Statistic
 
	- 
		Obtaining, Using, and Interpreting the p-Value
 
	- 
		Errors in Hypothesis Testing
 
	- 
		The Possible Mistakes We Can Make
 
	- 
		Other Important Concepts That are Essential in Statistical Inference
 
	- 
		Parametric and Nonparametric Statistical Methods
 
	- 
		Basic Principles of Statistics
 
	- 
		Probability Distributions
 
	- 
		Study Design
 
	- 
		Sample Size
 
	- 
		Data Collection and Preparing Data for Analysis
 
	- 
		Analysis and Presentation of Data
 
	- 
		Summarizing Data
 
	- 
		Comparing Groups: Continuous Data
 
	- 
		Comparing Groups: Categorical Data
 
	- 
		Comparing Groups: Time to Event Data
 
	- 
		Relation Between Two Continuous Variables
 
	- 
		Multivariable Analysis
 
	- 
		Conclusion