Section I. Neuroanatomy
Chapter 1. Neuroanatomy
-
Introduction
-
Embryological Differentiation of Different Parts of Brain
-
Anatomy of Brain
-
Vascular Supply of the Brain
-
The Meninges and Cerebrospinal Fluid
Chapter 2. Neuroembryology
-
Formation of Zygote
-
Formation of Blastocyst
-
Formation of Embryonic or Germ Disc
-
Formation of Definitive Notochord
-
Development of Nervous System
Chapter 3. Blood-Brain Barrier
-
Introduction
-
Permeability at the Blood-Brain Barrier
-
Cellular and Molecular Effects of Anesthetics on the Blood-Brain Barrier
-
Clinical and Experimental Implications of Anesthetics on the Blood-Brain Barrier
-
Conclusion
Section II. Neurophysiology
Chapter 4. Neurophysiology
-
Intracranial Pressure
-
Normal Intracranial Pressure
-
Cerebral Compliance
-
Importance of Intracranial Pressure
-
Summary
-
Cerebral Blood Flow
-
Vascular Anatomy
-
Summary
-
Brain Metabolism
-
Normal Cerebral Metabolism
-
Summary
-
Cerebrospinal Fluid
-
Ventricular System
-
Summary
-
The Spinal Cord
-
Anatomy
-
Organization of the Spinal Cord
-
Summary
Chapter 5. Brain Protection in Neurosurgery
-
Introduction
-
Nonpharmacological Strategies
-
Mild Hypothermia
-
Blood Pressure Control
-
Induced Arterial Hypertension
-
Normoglycemia
-
Target Hemoglobin Concentration
-
Pharmacological Strategies
-
Nonanesthetic Agents
-
Anesthetic Agents
-
Conclusion
Section III. Neuropharmacology
Chapter 6. Neuropharmacology
-
Anesthetic Drugs and Sedatives
-
Intravenous Anesthetic Agents
-
Inhalational Anesthetic Agents
-
Neuromuscular Blocking Agents
-
Local Anesthetic Agents
-
Miscellaneous Drugs
-
Future Directions in Neuropharmacology
-
Conclusion
Chapter 7. Anesthetic Agents: Neurotoxics or Neuroprotectives?
-
Introduction
-
Pharmacological Considerations
-
Anesthesia Practice: Clinical Outcomes
-
Anesthesia and Fragile Brain
-
Conclusion
-
Abbreviations
Section IV. Neuromonitoring
Chapter 8. Neuromonitoring
-
Introduction
-
Cerebral Blood Flow
-
Transcranial Sonography
-
Thermal Diffusion Flowmetry
-
Laser Doppler Flowmetry
-
Intra-Arterial 133Xenon
-
CT Perfusion
-
Xenon Enhanced CT
-
Positron Emission Tomography
-
Single Photon Emission Computed Tomography
-
Magnetic Resonance Imaging
-
Intracranial Pressure
-
Electroencephalogram
-
Evoked Potential Monitoring
-
Motor Evoked Potentials
-
Depth of Anesthesia
-
Cerebral Oxygenation Monitoring
-
Jugular Venous Oximetry
-
Regional Cerebral Oximetry
-
Brain Tissue Oxygen Monitoring
-
Cerebral Microdialysis
-
Conclusion
Chapter 9. Multimodal Monitoring
-
Introduction
-
Temperature
-
Oxygen Transport, Hemodynamics, and Brain Metabolism
-
Intracranial Pressure Monitoring
-
Electroencephalography and Depth of Anesthesia Monitoring
-
Miscellaneous
-
Integration of Information and Decision-Helping Systems
-
Clinical Pearls
Section V. Positions in Neurosurgery
Chapter 10. Positioning in Neurosurgery
-
Introduction
-
Historical Background
-
Principles of Positioning
-
The Conduct of Positioning
-
Surgical Approach for Craniotomies
-
Positioning for Craniotomy
-
Positions Used for Craniotomies
-
Surgical Approach for Procedures of the Spine
-
Conclusion
-
Abbreviations
Section VI. Preanesthetic Evaluation
Chapter 11. Preanesthetic Evaluation of Neurosurgical Patients
-
Introduction
-
Preoperative Evaluation of Patient-Related Risk Factors
-
Preoperative Evaluation of Specific Neurosurgical Conditions
Section VII. Neurosurgery
Chapter 12. Supratentorial Lesions
-
Introduction
-
Classification
-
Pathophysiology and Clinical Correlations
-
Clinical Features
-
Neuroimaging
-
Intraoperative Considerations: The Team Approach
-
Anesthetic Management
-
Intraoperative Management
-
Emergence From Anesthesia
-
Postoperative Management
-
Awake Craniotomy
-
Conclusions
Chapter 13. Emergence From Anesthesia
-
Introduction
-
Neurophysiological Response During Emergence in Neurosurgical Patients
-
Specific Perioperative Considerations
-
Delayed Emergence and Arousal
-
Complications
-
Conclusion
Chapter 14. Anesthesia for Posterior Fossa Surgery
-
Introduction
-
Anatomy
-
Clinical Presentation
-
Perioperative Management of Patients for Posterior Fossa Surgery
-
Venous Air Embolism
-
Postoperative Management
-
Complications
-
Abbreviations
Chapter 15. Transesophageal Echocardiography
-
Introduction
-
Basics of Transesophageal Echocardiography
-
Summary
Chapter 16. Anesthesia for Epilepsy Surgery
-
Introduction
-
Surgical Management of Epilepsy
-
Types of Surgical Treatment
-
Presurgical Evaluation
-
Anesthesia for Epilepsy Surgery
-
Effect of Anesthetic Agents in Patients With Epilepsy
-
Antiepileptic Drug Interactions
-
Preanesthetic Evaluation and Preparation
-
Anesthetic Management of Preoperative Procedures
-
Anesthesia for Intracranial Electrode Insertion
-
Anesthetic Management of Resection of Seizure Focus
-
Awake Craniotomy
-
Resection of Epileptogenic Focus Under General Anesthesia
-
Neurostimulation for Drug-Resistant Epilepsy
-
Anesthetic Management of the Patient With Epilepsy for Incidental Surgery
-
Abbreviations
Chapter 17. Refractory Status Epilepticus
-
Introduction
-
Epidemiology
-
Classification
-
Cause
-
Pathophysiology
-
Diagnosis
-
Management
-
Treatment
-
Conclusions
Chapter 18. Aneurysmal Subarachnoid Hemorrhage
-
History
-
Introduction
-
Clinical Presentation and Diagnosis
-
Grading of Subarachnoid Hemorrhage
-
Initial Management Concerns in Neurocritical Care Unit
-
Timing of Surgery
-
Clipping or Coiling
-
Evaluation of a Patient With Subarachnoid Hemorrhage for Anesthesia
-
Anesthetic Management
-
Temporary Clipping and Brain Protection Strategy
-
Intraoperative Aneurysm Rupture
-
Giant Aneurysms and Circulatory Arrest
-
Endovascular Management for Aneurysm Ablation
-
Postoperative Management of Patients
-
Conclusion
Chapter 19. Circulatory Arrest
-
Introduction
-
Deep Hypothermic Circulatory Arrest
-
Anesthesia Management
-
Complications
-
Adenosine-Induced Circulatory Arrest
-
Anesthesia Considerations
-
Complications
-
Summary
Chapter 20. Cerebrovascular Disease
-
Intracerebral Hemorrhage
-
Incidence and Risk Factors
-
Imaging
-
Clinical Presentation
-
Management of Intracerebral Hemorrhage
-
Arteriovenous Malformations
-
Cause and Incidence
-
Natural History
-
Pathophysiologic Effects and Clinical Presentation
-
Grading of Arteriovenous Malformations
-
Imaging
-
Cerebral Hemodynamics in Arteriovenous Malformation
-
Management
-
Surgical Resection of Arteriovenous Malformation
-
Anesthetic Considerations for Resection of Arteriovenous Malformation
-
Postoperative Management
-
Anesthetic Considerations for Arteriovenous Malformation Embolization
-
Complications During Arteriovenous Malformation Embolization
-
Pediatric Arteriovenous Malformations
-
Pregnancy and Arteriovenous Malformations
-
Vein of Galen Aneurysmal Malformations
-
Dural Arteriovenous Fistula
-
Clinical Presentation
-
Management
-
Carotid Endarterectomy
-
Preoperative Evaluation
-
Management of Carotid Artery Disease
-
Monitoring
-
Intraoperative Management
-
Postoperative Complications and Outcomes
-
Coronary Angioplasty and Stenting
-
Moyamoya Disease
-
Management of Moyamoya Disease
Chapter 21. Flow Arrest in Cerebrovascular Surgery
-
Deep Hypothermic Circulatory Arrest
-
Adenosine-Assisted Cerebral Blood Flow Arrest
-
Rapid Ventricular Pacing-Assisted Cerebral Blood Flow Arrest
Chapter 22. Neuroendocrine Lesions
-
Hypothalamic-Pituitary-Adrenal Axis Evaluation
-
Neuroendocrine Response Related to Anesthesia and Surgery
-
Pituitary Gland Adenomas
-
Physiology of Pituitary Gland
-
Endocrine Diseases
-
Nonfunctioning Tumors
-
Intraoperative Considerations
-
Advantages of Endoscopic Endonasal Approach
-
Relative Contraindications to Transsphenoidal Approach
-
Intraoperative Issues
-
Disorder of Water and Electrolytes
Chapter 23. Pituitary Apoplexy
-
Clinical Features
-
Management
Chapter 24. Spinal Surgery
-
Introduction
-
Spine
-
Types of Spine Surgeries
-
Surgical Approaches to the Spine
-
Common Spine Disorders
-
Imaging in Spine Lesions
-
Positioning for Spine Surgeries
-
Neurophysiological Intraoperative Monitoring During Spine Surgeries
-
Preanesthetic Assessment and Optimization
-
Anesthesia Management
-
Postoperative Management
-
Special Considerations
-
Conclusion
Chapter 25. Postoperative Visual Loss
-
Introduction
-
Central Retinal Artery Occlusion
-
Ischemic Optic Neuropathy
-
Cortical Blindness
-
Recent Advances
-
Conclusion
Chapter 26. Neuroendoscopy
-
Introduction
-
Anesthetic Goals and Management
-
Anesthetic Management of Specific Neuroendoscopic Procedures
-
Advances in Neuroendoscopy
-
Conclusion
-
Clinical Pearls
Chapter 27. Pressure Inside the Neuroendoscope
-
Introduction
-
Indications and Procedures
-
How Do Neurosurgeons Perform an Intraventricular Endoscopic Procedure?
-
Anesthetic Procedure: What to Take Into Account?
-
Perioperative Complications
-
Conclusion
Chapter 28. Anesthesia for Functional Neurosurgery
-
Introduction
-
Procedure
-
Anesthetic Consideration
-
Anesthetic Techniques
-
Complications
-
Anesthesia in Patients With Deep Brain Stimulator In Situ
-
Conclusion
Chapter 29. Awake Craniotomy
-
Introduction
-
Patient Selection
-
Awake Craniotomy for Tumor Surgery
-
Awake Craniotomy for Epilepsy
-
Conclusion
Section VIII. Neuroradiology
Chapter 30. Anesthesia for Neuroradiology
-
Introduction
-
Issues Relating to Anesthesia Care in Neuroradiology
-
Anesthesia for Computed Tomographic Study
-
Anesthesia for Magnetic Resonance Imaging Study
-
Anesthesia for Diagnostic Angiography
-
Anesthetic Management of Endovascular Coiling
-
Anesthetic Management of Endovascular Embolization of Arteriovenous Malformation, Arteriovenous Fistula, and Vein of Galen Malformation
-
Anesthesia for Stroke Interventions
-
Issues Related to Radiation During Neurointervention
-
Anesthesia for Stereotactic Radiosurgery
-
Pregnancy and Neuroradiology
-
Clinical Pearls
Chapter 31. Magnetic Resonance Imaging: Anesthetic Implications
-
Introduction: The Road From X-Ray to Magnetic Resonance Imaging
-
Principles of Nuclear Magnetic Resonance and Magnetic Resonance Imaging
-
Various Types of Signals Recorded
-
Hazards Related to Magnetic Resonance Imaging
-
Magnetic Resonance Imaging Safety: General Considerations
-
Magnetic Resonance Imaging Safety: Management of Cardiac Implantable Electronic Devices and Other Implantable Devices
-
Anesthesia for Magnetic Resonance Imaging
-
Research Applications/Emerging Clinical Applications of Magnetic Resonance Imaging
Section IX. Neurotrauma
Chapter 32. Neurotrauma
-
Traumatic Brain Injury
-
Definition
-
Epidemiology
-
Classification of Traumatic Brain Injury
-
Physiologic Response to Brain Injury
-
Neuroimaging
-
Severity of Traumatic Brain Injury
-
Management of Traumatic Brain Injury
-
Outcome
-
Emerging Treatment Modalities
-
Conclusion
-
Spine and Spinal Cord Trauma
-
Epidemiology
-
Classification of Spinal Injury
-
Pathophysiology of Spinal Cord Trauma
-
Systemic Complications of Spinal Cord Injuries
-
Management of Spine and Spinal Cord Injury
-
Emerging Treatment Modalities
Chapter 33. Biomarkers in Traumatic Brain Injury
Section X. Neurointensive Care
Chapter 34. Neurological Critical Care
-
Introduction
-
History of Neurocritical Care
-
Design of a Neurocritical Care Unit
-
Clinical Conditions Requiring Admission to Neurocritical Care Unit
-
Justification for Neurological Critical Care Units
-
Pathophysiological Issues in Neurological Critical Care
-
Management of Patients in a Neurological Intensive Care Unit
-
Management of General Systemic Physiology
-
Specific Therapeutic Issues in Individual Clinical Conditions
-
Advanced Neuromonitoring
-
Outcomes of Neurological Intensive Care Unit
-
End-of-Life Issues in Neurological Critical Care
-
Clinical Pearls
Chapter 35. Antibiotics: Prophylactic and Therapeutics
-
Introduction
-
Principles of Antimicrobial Therapy in Neurosurgery
-
Treatment of Central Nervous System Infections in the Neurosurgical Patient
-
Antimicrobial Prophylaxis in Neurosurgery
Section XI. Special Considerations
Chapter 36. Pediatric Neuroanesthesia
-
Overview
-
Pediatric Neurophysiology
-
General Principles of Pediatric Neuroanesthesia
-
Intraoperative Management
-
Postoperative Considerations
-
Management of Specific Conditions
-
Conclusion
Chapter 37. Fluid and Blood Transfusion in Pediatric Neurosurgery
-
Introduction
-
Fluid and Electrolyte Choices
-
Type of Fluids for Perioperative Administration in Pediatric Patients
-
Fluid Management in Pediatric Neurosurgery
-
Osmotherapy
-
Fluid and Electrolyte Disturbances in Pediatric Neurosurgery
-
Blood Transfusion
-
Blood Components
-
Special Situations
-
Epilepsy Surgery
-
Scoliosis
-
Conclusion
Chapter 38. Geriatric Neuroanesthesia
-
Introduction
-
Implications of Surgical Stress and Anesthesia on the Elderly
-
Neurosurgical Concerns Unique to the Elderly
-
Conclusion
Chapter 39. Postoperative Cognitive Dysfunction
-
Introduction
-
Definitions, Epidemiology, and Pathophysiology
-
Risk Factors
-
Prevention
-
Screening Tools
-
Treatment
-
Outcome
Chapter 40. Pregnancy
-
Requirement of Neurosurgery During Pregnancy
-
Physiological Alterations During Pregnancy
-
Effect of Anesthetic Agents on Fetal Outcome
-
Uteroplacental Drug Transfer and Neonatal Depression
-
Timing and Method of Delivery
-
Anesthetic Considerations During Pregnancy
-
Induction: Rapid Sequence Versus Slow Neuroinduction
-
Combined Cesarean Delivery and Neurosurgery
-
Intracranial Pressure and Regional Anesthesia
-
Postoperative Management
-
Anesthesia for Interventional Neurosurgical Procedures
Chapter 41. Cerebral Venous Thrombosis
-
Definition
-
Venous Anatomy
-
Incidence of Cerebral Venous Thrombosis
-
Risk Factors
-
Pathophysiology
-
Clinical Manifestations
-
Diagnostic Evaluation
-
Treatment
-
Anesthetic Management
-
Prognosis
-
Conclusion
Chapter 42. Neurosurgical Anesthesia in Patients With Coexisting Cardiac Disease
-
Introduction
-
Preoperative Evaluation
-
Risk Stratification
-
Perioperative Monitoring
-
Ischemic Heart Disease
-
Valvular Heart Disease
-
Tumors of the Heart
-
Congenital Heart Disease
-
Hypertension
-
Conclusion
Chapter 43. Intraoperative Cardiopulmonary Resuscitation
-
Introduction
-
Incidence, Morbidity, and Mortality
-
Survival From Intraoperative Cardiac Arrest
-
Predictors
-
Cause of Intraoperative Cardiac Arrest
-
Cardiopulmonary Resuscitation Quality
-
Cardiac Arrest and Cardiopulmonary Resuscitation in Neurosurgical Patients
-
Prognosis
-
Conclusion
Chapter 44. Coexisting Diabetes Mellitus in Neurosurgical Patients
-
Introduction
-
Incidence of Diabetes Mellitus
-
Glycemic Indices
-
Modes of Glucose Measurement
-
Pathophysiology of Diabetes Mellitus
-
Cerebral Glucose Metabolism
-
Hyperglycemia and the Brain
-
Hyperglycemic Neuropathy
-
Diabetic Dysautonomia
-
Hypoglycemia and the Brain
-
Evidence of Glycemic Control in Important Neurosurgical Subsets
-
Traumatic Brain Injury
-
Subarachnoid Hemorrhage
-
Cerebrovascular Accidents
-
Tumor Surgery
-
Spine Surgery
-
Blood Sugar Management in Perioperative Period and Neurocritical Care
-
Intraoperative Management
-
Anesthetic Management
-
Postoperative Glycemic Management
-
Blood Sugar Control in Emergency Neurosurgical Patient
-
Blood Sugar Control in Intensive Care Setup
-
Nutrition
-
Conclusions
-
Coexisting Hypertension in Neurosurgical Patients
-
Physiology of Cerebral Circulation
-
Pathophysiology of Arterial Hypertension
-
Hypertension in Patients With Traumatic Brain Injury
-
Perioperative Management
-
Preoperative Evaluation
-
Antihypertensive Drugs
-
Intraoperative Management
-
Monitoring
-
Induction of Anesthesia
-
Maintenance of Anesthesia
-
Recovery From Anesthesia
-
Postoperative Care
-
Neurocritical Care
-
Conclusion
Chapter 45. Neuromuscular Disorders
-
Introduction
-
Myasthenia Gravis
-
Myasthenic Crisis
-
Lambert-Eaton Myasthenic Syndrome
-
Guillain-Barré Syndrome
-
Periodic Paralysis
-
Myotonias
-
Muscular Dystrophies
-
Motor Neuron Diseases
-
Multiple Sclerosis
-
Parkinson’s Disease
-
Alzheimer’s Disease
-
Huntington’s Disease
Chapter 46. Neuromuscular Electrical Stimulation in Critically Ill Patients
-
Introduction
-
Neuromuscular Electrical Stimulation: Basic Concepts and Practical Considerations
-
Neuromuscular Electrical Stimulation in the Intensive Care Unit
-
Contraindications and Adverse Effects
-
Recommendations for the Use of Neuromuscular Electrical Stimulation in the Intensive Care Unit
Chapter 47. Neurological Patients for Nonneurosurgeries
-
Neurodegenerative Diseases
-
Demyelinating Disease
-
Neuromuscular Disease: Myasthenia Gravis
-
Epilepsy
-
Intracranial Tumors
-
Traumatic Brain Injury
Chapter 48. Anesthesia for Electroconvulsive Therapy
-
Background
-
Technique of Electroconvulsive Therapy
-
Contraindications
-
Preprocedure Management
-
Anesthesia for Electroconvulsive Therapy
-
Side Effects
-
Special Conditions
-
Conclusion
Section XII. Fluids and Electrolyte Management
Chapter 49. Fluids and Electrolyte Management
-
Introduction
-
Anatomy and Physiology
-
Pathophysiology
-
Definitions
-
Choice of Fluids
-
Hypertonic Fluids
-
Isotonic Fluids
-
Colloids
-
Hypotonic Fluids
-
Fluid Management
-
Commonly Encountered Fluid Abnormalities
-
Conclusion
-
Clinical Pearls
Chapter 50. Crystalloid and Colloid Fluids
-
Crystalloid Fluids
-
Colloid Fluids
-
Which Fluid to Choose?
-
Conclusions
Section XIII. Pain Management
Chapter 51. Pain Management
-
Postcraniotomy Pain
-
Incidence
-
Anatomical and Physiological Basis of Pain Following Craniotomy
-
Pain-Sensitive Structures of Cranium
-
Pathogenesis of Postcraniotomy Pain
-
Factors Affecting Postcraniotomy Pain
-
Classification and Assessment of Postcraniotomy Pain
-
Preemption of Pain
-
Treatment of Acute Pain
-
Postcraniotomy Pain Management in the Pediatric Population
-
Conclusion
-
Acute Pain Management After Spinal Surgery
-
Pathophysiology
-
Treatment Modalities for Acute Postoperative Spinal Pain
-
Conclusion
Section XIV. Brain Death and Ethical Issues
Chapter 52. Brain Death and Ethical Issues in Neuroanesthesia Practice
-
Part A: Brain Death
-
Criteria for Diagnosing Death
-
Need for Brain Death Diagnosis
-
Rules Regulating Diagnosis of Brain Death
-
Criteria for Certifying Brain Stem Death
-
Pitfalls/Controversies
-
Conclusion
-
Appendix I
-
Part B: Ethical Issues in Neuroanesthesia Practice
-
Ethical Issues in Clinical Care
-
Ethical Issues Related to Research
-
Ethical Issues Related to Team Work
-
Ethical Issues Related to Training
-
Ethical Issues Related to Innovative Neurosurgery
-
Conclusion
Chapter 53. Organ Donation
Section XV. Evidence-Based Practice
Chapter 54. Evidence-Based Practice of Neuroanesthesia
-
Introduction
-
Evidence-Based Practice and Neuroanesthesia
-
Evidence and the Brain Trauma Foundation Guidelines
-
Unresolved Issues in the Practice of Neuroanesthesia
-
Conclusion
-
Clinical Pearls
Chapter 55. Translational Research
-
Introduction
-
Definition
-
In Neuroanesthesia
-
Why Not Lead to Clinical
-
To Be a Successful Translation
-
Conclusion
Section XVI. Recent Advances
Chapter 56. Recent Advances in Neuroanesthesiology
-
Introduction
-
Endovascular Treatment of Stroke and Perioperative Stroke
-
Indications for Deep Brain Stimulation
-
Anesthetic Neurotoxicity
-
Pre- and Postconditioning
-
Brain Monitoring
-
New Assays for Creutzfeldt-Jakob Disease
Chapter 57. Stem Cell Therapy
-
Hypothesis of Stem Cell Research
-
Stem Cell
-
Historical Background
-
Types of Stem Cells
-
Sources of Stem Cells
-
Mesenchymal Stem Cells
-
Stem Cells in Neurological Diseases
-
Mode of Action of Stem Cell Therapy
-
Ethical Issues
-
Recent Advances
Chapter 58. Pharmacogenomics
-
Introduction
-
Basic Genetic Principles
-
Basic Pharmacologic Principles
-
Anesthesia Contribution to the History of Pharmacogenomics
-
Pharmacogenomics: Current Application to Clinical Anesthesia
-
Conclusion
Section XVII. Sterilization Techniques
Chapter 59. Sterilization and Disinfection
-
Background
-
Recommendation of Preferred Methods for Various Medical Devices
-
Recommendation for the Cleaning and Decontamination of Environmental Surfaces
-
Recommendation for Blood Spill on the Surface
-
Cleaning and Disinfection of Medical Instruments
-
Cleaning and Reprocessing of Patient Care Equipment
-
Reprocessing of Respiratory Apparatus and Endoscopes
-
Reprocessing of Endoscopes
-
Specific Issues
-
Special Precaution for Inactivation of Creutzfeldt-Jakob Disease
-
Health Care-Associated Infections
-
Infections in Operating Rooms and Intensive Care Units
-
Conclusion
Chapter 60. Universal Precautions in the Intensive Care Unit
-
Introduction
-
Prophylactics of Health Care-Associated Infections in the Intensive Care Unit
-
Early Diagnosis of Pathogens and Infection Complications in the Intensive Care Unit
-
Rational Antibiotic Therapy
-
Systemic Approach
-
Conclusion
Section XVIII. Palliative Care
Chapter 61. Palliative Care to Neurological and Neurosurgical Patients
Chapter 62. Quality of Life and Health-Related Issues
-
Introduction
-
Quality of Life and Health-Related Quality of Life
-
Utility of Health-Related Quality of Life
-
Tools for Measuring Health-Related Quality of Life
-
Uses of Measuring Health-Related Quality of Life
-
Health-Related Quality of Life in Relation to Neurosurgical/Neurological Conditions
-
Conclusion
Section XIX. Biostatistics
Chapter 63. Biostatistics
-
Introduction to Biostatistics
-
Definition of Statistics
-
Biostatistics and Its Applications
-
Uses of Statistical Methods in Medical Sciences
-
Some Basic Statistical Concepts
-
Population and Sample
-
Scale of Measurements
-
Constant
-
Variables
-
Parameter and Statistic
-
Ratio, Proportion, and Rate
-
Statistical Inference
-
Estimation
-
Hypothesis Testing
-
Steps in Hypothesis Testing or Testing the Statistical Significance
-
Defining the Null and Alternative Hypotheses
-
Calculating the Test Statistic
-
Obtaining, Using, and Interpreting the p-Value
-
Errors in Hypothesis Testing
-
The Possible Mistakes We Can Make
-
Other Important Concepts That are Essential in Statistical Inference
-
Parametric and Nonparametric Statistical Methods
-
Basic Principles of Statistics
-
Probability Distributions
-
Study Design
-
Sample Size
-
Data Collection and Preparing Data for Analysis
-
Analysis and Presentation of Data
-
Summarizing Data
-
Comparing Groups: Continuous Data
-
Comparing Groups: Categorical Data
-
Comparing Groups: Time to Event Data
-
Relation Between Two Continuous Variables
-
Multivariable Analysis
-
Conclusion