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This book addresses Epigenetics in Cancer and covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years.
Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively.
By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resourcefor scientists, graduate students and clinicians alike.
Pages i-vi
Front Matter
Pages 1-1
RNA Modifications in Cancer Metabolism and Tumor Microenvironment
Pages 3-24
RNA Modifications in Cancer Stem Cell Biology
Pages 25-47
Recent Advances of RNA m6A Modifications in Cancer Immunoediting and Immunotherapy
Pages 49-94
Recent Advances in RNA m6A Modification in Solid Tumors and Tumor Immunity
Pages 95-142
Recent Advances in Adenosine-to-Inosine RNA Editing in Cancer
Pages 143-179
RNA Modifications in Hematologic Malignancies
Pages 181-207
Front Matter
Pages 209-209
The SWI/SNF Complex: A Frequently Mutated Chromatin Remodeling Complex in Cancer
Pages 211-244
Histone Readers and Their Roles in Cancer
Pages 245-272
Polycomb Repressive Complex 2 in Oncology
Pages 273-320
Epigenetic (De)regulation in Prostate Cancer
Pages 321-360
Front Matter
Pages 361-361
Ten-Eleven-Translocation Genes in Cancer
Pages 363-373
Inferring the Cancer Cellular Epigenome Heterogeneity via DNA Methylation Patterns
Pages 375-393
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