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This book covers all aspects of hypersensitivity to drugs, providing practical information for non-specialist physicians as well as addressing issues of interest to practitioners in different specialties and presenting the expert knowledge required by specialist allergists and immunologists. The opening, general section discusses basics such as clinical manifestations, histopathology, mechanisms, risk factors, drug hypersensitivity in particular populations, and the full range of diagnostic methods. The second part of the book provides concise information on the most important drug classes and guides the reader on how to proceed when patients present with a suspected reaction. For each drug class, the current level of evidence for use of the different diagnostic tools, including skin tests, provocation tests, and in vitro tests, is clarified, and management options, outlined. The inclusion of helpful tables and algorithms is designed to aid in decision making. Drug hypersensitivity is among the more complex allergological issues, and this book will meet the needs of general practitioners, internists, and specialists.
Pages i-xxxii
Front Matter
Pages 1-1
Classification and Terminology of Drug Hypersensitivity Reactions
Pages 3-9
Pages 11-19
Cutaneous Signs and Syndromes of Drug Hypersensitivity
Pages 21-27
Systemic Organ Manifestations of Drug Allergy
Pages 29-42
Danger Signs in Drug Hypersensitivity
Pages 43-45
Pathomechanisms of Drug Hypersensitivity Targeting the Liver and Skin
Pages 47-57
Front Matter
Pages 59-59
Pages 61-68
Pages 69-78
T-Cell Assays for the Investigation of Drug Hypersensitivity
Pages 79-90
Pages 91-97
Histopathology of Drug-Induced Exanthemas
Pages 99-105
Front Matter
Pages 107-107
Drug Desensitization in Immediate-Type Hypersensitivity
Pages 109-126
Documentation for Patients with Drug Hypersensitivity: Allergy Pass and Allergy Card
Pages 127-131
Front Matter
Pages 133-133
Pages 135-146
Pages 147-154
Oncology: Immune Checkpoint Inhibitors
Pages 155-159
Drug Hypersensitivity and Clonal Mast Cell Disorders
Pages 161-165
Front Matter
Pages 167-167
Pages 169-176
Pages 177-186
Pages 187-191
Pages 193-195
Cutaneous Hypersensitivity Reactions to Analgesics and Nonsteroidal Anti-Inflammatory Drugs
Pages 197-205
Peri-Interventional Hypersensitivity: Anesthetic Drugs and Materials
Pages 207-214
Pages 215-222
Pages 223-231
Pages 233-237
Pages 239-250
Pages 251-256
Antiepileptic and Psychotropic Drugs
Pages 257-266
Antiacid drugs: Proton Pump Inhibitors and H2 Receptor Antagonists
Pages 267-272
Pages 273-278
Pages 279-286
Pages 287-290
Pages 291-295
Pages 297-304
Additives: Preservatives, Antioxidants, Dyes, and Others
Pages 305-312
Pages 313-319
Pages 321-327
Pages 329-337
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