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Infertility is an important health problem affecting around 15% of couples worldwide, with profound psycho-social consequences and impairment of patients’ quality of life. It has been shown that the male factor is solely and partially implicated in 20-50% of the cases of infertility. Male infertility is a complex issue that can be related to a variety of congenital or acquired factors that lead to a decline in the quantity and/or the quality of semen. Over the recent years, there have been major advances in basic understanding of the factors that regulate male fertility, the diagnostic tests for assessment of male fertility potential, and the therapeutic options for the management of male subfertility/infertility. However, despite advances in technologies and diagnostic methods in the field of andrology, there remains a significant subset of these subfertile men who are classified as having unexplained or idiopathic male infertility. In addition, there are ongoing debates and controversies on the clinical management of infertile men under certain conditions like varicocele, genital tract inflammation/infection or non-obstructive azoospermia.
This book discusses advances in cellular, molecular, and genetic aspects of spermatogenesis and sperm evaluation in the context of clinical scenarios. It also addresses clinical dilemmas and controversies through a discussion of the basic science underlying these conditions. The authors form an impressive international collaboration to provide a unique perspective that specializes in all key areas of andrology.
Current and Future Advances in Male Infertility provides insights into strategies to reduce the burden of male gonadotoxins, to enhance men’s fecundity and to help optimize the care of infertile men. It aims to bridge the gap between researchers and clinicians by integrating basic science and clinical application.
Pages i-xiv
Front Matter
Pages 1-1
Clinical Implications of the WHO 6th Edition on Human Semen Analysis
Pages 3-16
Endocrine-Disrupting Chemicals (EDCs) and Male Infertility
Pages 17-42
Lifestyle Modifications and Male Infertility
Pages 43-66
Impact of Testicular Cancer on Male Fertility
Pages 67-85
Front Matter
Pages 87-87
Impact of Sperm DNA Fragmentation on Natural and Assisted Conception
Pages 89-108
Front Matter
Pages 109-109
Pathophysiology of Seminal Oxidative Stress
Pages 111-126
Management of Male Oxidative Stress Infertility (MOSI)
Pages 127-151
Front Matter
Pages 153-153
Advances in Genetics of Male Infertility
Pages 155-174
Epigenetic Alterations in Male Infertility
Pages 175-195
Front Matter
Pages 197-197
New Insights into the Pathophysiology of Varicocele in Male Infertility
Pages 199-219
Clinical Dilemmas and Controversies in Varicocele Management
Pages 221-241
Front Matter
Pages 243-243
Challenges in the Diagnosis and Treatment of Male Accessory Gland Infection (MAGI)
Pages 245-263
Front Matter
Pages 265-265
Epidemiologic Features and Management of Sexual Dysfunctions in Infertile Men
Pages 267-279
Front Matter
Pages 281-281
Hypogonadism in Infertile Men: A Clinical Minefield
Pages 283-302
Challenges in the Management of Nonobstructive Azoospermia
Pages 303-322
Alternative Approaches to the Treatment of Male Infertility
Pages 323-343
A Comprehensive Guide to Sperm Optimization Prior to ART
Pages 345-368
Artificial Intelligence in Andrology and Reproductive Medicine
Pages 369-390
New Frontiers of Research and Therapy in Male Infertility
Pages 391-400
Pages 401-407
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