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This textbook describes several diseases and clinical conditions, from physiopathological mechanisms to main clinical pictures, highlighting the importance of laboratory medicine, with the aim to provide the necessary tools for guiding correct laboratory findings interpretation.
Indeed, it is now widely recognized that laboratory medicine has a pivotal role in clinical medicine, significantly influencing clinical decisions. Thus, it is crucial to understand and use laboratory data appropriately.
This book has the great advantage of describing each topic exhaustively in order to facilitate its understanding. Specifically, it describes both diseases with a high incidence in the population, such as Diabetes Mellitus, Cardiovascular Diseases, Dyslipidemias, and Autoimmune Diseases, as well as rare diseases, such as Hereditary Metabolic Diseases. In addition, unusual topics are treated, such as Clinical Biochemistry of the Mind, as well as hot topics, such as Biological Drugs, Biobanks, Health Technology Assessment, and Omics Sciences. Finally, the book includes a chapter on the new health emergency, the SARS-CoV-2 pandemic. Two appendices are provided at the end of the book: a table summarizing the reference range and decisional cut-off for the main laboratory parameters and instructions on performing a venous blood sample.
The book will be an invaluable tool for medical and biomedical students, as well as for practitioners.
Front Matter
Pages i-xvii
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The Role of Laboratory Medicine in the Clinical Context
Marcello Ciaccio
Pages 1-5
The Laboratory Diagnostic Process
Mario Plebani
Pages 7-13
Elements of Biomedical Laboratory Organization
Giuseppe Lippi, Camilla Mattiuzzi, Chiara Bovo
Pages 15-20
The Role of Statistics in Laboratory Medicine
Matteo Vidali
Pages 21-42
Elements of Metrology
Orazio Ruzzenente, Claudio Brentegani
Pages 43-46
The Pre-analytical Phase
Davide Giavarina
Pages 47-56
The Quality of Laboratory Results: Sources of Variability, Methods of Evaluation, and Estimation of Their Clinical Impact
Ferruccio Ceriotti, Mauro Panteghini
Pages 57-61
Principles of Immunochemistry
Antonio Fortunato
Pages 63-75
General Information on Laboratory Tests and Biomarkers
Giuseppe Lippi, Elisa Danese, Martina Montagnana
Pages 77-82
Enzymes and Their Clinical Use
Ilenia Infusino, Ferruccio Ceriotti, Mauro Panteghini
Pages 83-93
Liver: From Biochemistry to Clinical Biochemistry
Marcello Ciaccio, Luisa Agnello, Anna Maria Ciaccio
Pages 95-123
Protein Diagnostics
Maria Stella Graziani, Anna Caldini
Pages 125-137
Biomarkers of Nutritional Status
Marcello Ciaccio, Luisa Agnello, Rosaria Vincenza Giglio, Anna Maria Ciaccio
Pages 139-143
Dyslipidemias
Marcello Ciaccio, Luisa Agnello, Bruna Lo Sasso, Rosaria Vincenza Giglio, Anna Maria Ciaccio
Pages 145-161
Hematological Diagnostics
Gian Cesare Guidi
Pages 163-193
Immunohematology
Gianluca Gessoni
Pages 195-219
Hemostasis
Giuseppe Lippi, Gian Luca Salvagno, Massimo Franchini
Pages 221-235
Kidney
Michele Mussap
Pages 237-252
Physical, Chemical, and Morphological Urine Examination
Fabio Manoni
Pages 253-267
Hydroelectrolytic Disorders
Marcello Ciaccio, Anna Maria Ciaccio, Luisa Agnello
Pages 269-281
Blood Gas Analysis
Paolo Carraro
Pages 283-293
Cardiac Biomarkers
Aldo Clerico, Martina Zaninotto
Pages 295-306
Biomarkers of Stroke
Marcello Ciaccio, Luisa Agnello
Pages 307-312
Thrombophilia
Marcello Ciaccio
Pages 313-315
Endocrine System
Marcello Ciaccio, Luisa Agnello, Giulia Bivona, Anna Maria Ciaccio, Bruna Lo Sasso
Pages 317-382
Diabetes Mellitus: From Definition to Therapy
Marcello Ciaccio, Anna Maria Ciaccio, Luisa Agnello
Pages 383-397
Diabetes Mellitus: The Role of the Laboratory
Andrea Mosca, Martina Montagnana
Pages 399-410
Metabolic Syndrome
Marcello Ciaccio, Anna Maria Ciaccio, Luisa Agnello
Pages 411-413
Hypoglycemia
Marcello Ciaccio, Luisa Agnello
Pages 415-421
The Role of Laboratory in Pregnancy
Marcello Ciaccio, Luisa Agnello
Pages 423-435
Hereditary Metabolic Diseases
Carlo Corbetta, Carlo Dionisi Vici
Pages 437-446
Hyperphenylalaninemias, Tyrosinemias, Glycogenosis, Hyperammonemia
Marcello Ciaccio, Luisa Agnello
Pages 447-453
Circulating Biomarkers in Oncology: Areas of Application, Critical Issues, and Perspectives
Massimo Gion, Chiara Trevisiol, Aline S. C. Fabricio
Pages 455-465
Liquid Biopsy
Marcello Ciaccio
Pages 467-473
Biological Fluids
Gaetato Bernardi, Cosimo Ottomano, Sabrina Buoro
Pages 475-488
Laboratory Diagnostics in Autoimmune Diseases
Tommaso Trenti, Alessandra Melegari, Chiara Bonaguri
Pages 489-500
Laboratory Diagnostics in Allergic Diseases
Alda Tiziana Scacchetti, Tommaso Trenti
Pages 501-507
Biomarkers of Bone Remodeling
Franca Pagani, Martina Zaninotto
Pages 509-526
Alzheimer’s Disease and Other Neurodegenerative Dementias
Giulia Sancesario, Sergio Bernardini
Pages 527-532
In Vivo Clinical Biochemistry
Caterina Tonon, Raffaele Lodi, Claudia Testa, Stefania Evangelisti
Pages 533-551
Clinical Biochemistry of the Mind
Silvia Pellegrini, Pietro Pietrini
Pages 553-564
Clinical Molecular Biology
Ettore Domenico Capoluongo, Giuseppe Castaldo
Pages 565-576
Fever of Unknown Origin
Marcello Ciaccio, Luisa Agnello, Anna Maria Ciaccio
Pages 577-581
Biomarkers of Inflammation
Marcello Ciaccio, Luisa Agnello, Anna Maria Ciaccio
Pages 583-588
Biomarkers of Sepsis
Giuseppe Lippi, Gianfranco Cervellin, Marcello Ciaccio, Luisa Agnello
Pages 589-595
Laboratory Medicine and Exercise
Marcello Ciaccio, Luisa Agnello
Pages 597-599
Clinical Biochemistry of Exercise
Giuseppe Lippi, Nicola Maffulli
Pages 601-610
Preoperative Laboratory Test
Marcello Ciaccio
Pages 611-613
The Role of Laboratory in Urgency/Emergency
Marcello Ciaccio, Luisa Agnello, Paolo Carraro
Pages 615-620
Biological Drugs
Marcello Ciaccio, Bruna Lo Sasso, Salvatore Milano, Caterina Maria Gambino
Pages 621-629
Mass Spectrometry in Clinical Biochemistry and Laboratory Medicine
Giorgio Federici, Marcello Ciaccio
Pages 631-640
Toxicology and Analytical Pharmacology
Sergio Bernardini, Simona Martello, Antonello Nonnato, Davide Farci Santarcangeli
Pages 641-657
Pharmacotoxicology of Substances of Abuse
Roberta Pacifici, Simona Pichini, Manuela Pellegrini, Paolo Berretta
Pages 659-681
Applications of “Omics” Sciences in the Laboratory
Valeria D’Argenio, Barbara Lombardo, Marcella Nunziato, Lucio Pastore
Pages 683-691
COVID-19
Marcello Ciaccio, Luisa Agnello, Rosaria Vincenza Giglio
Pages 693-703
From Aging to Healthy Longevity: Innovation in Medicine Including Predictive Medicine and Laboratory Medicine Approaches
Francesco Salvatore
Pages 705-712
Biobanks of Biomedical Interest
Marialuisa Lavitrano, Barbara Parodi, Maria Grazia Daidone, Mattia Barbareschi, Aldo Scarpa, Matteo Macilotti et al.
Pages 713-720
Health Technology Assessment in Laboratory Medicine
Lucrezia Ferrario, Elisabetta Garagiola, Fabrizio Schettini, Emanuela Foglia
Pages 721-729
Back Matter
Pages 731-739
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