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Chronic Lymphocytic Leukemia: Who, How, and Where?
Pages 3-17
This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.
Chronic Lymphocytic Leukemia: Who, How, and Where?
Pages 3-17
Laboratory Diagnosis of Chronic Lymphocytic Leukaemia
Pages 21-35
The Clinical Presentation of CLL
Pages 39-50
Prognostic Markers
Pages 53-65
Guidelines for Diagnosis, Indications for Treatment, Response Assessment, and Supportive Management of Chronic Lymphocytic Leukemia: The 2018 Update
Pages 69-77
Initial Therapy of Chronic Lymphocytic Leukemia
Pages 79-96
CLL with Del (17p)/TP53 Mutation
Pages 97-106
Treatment of Relapsed and Refractory Chronic Lymphocytic Leukemia
Pages 107-119
Autoimmune Cytopenia in Chronic Lymphocytic Leukemia
Pages 123-136
Richter Syndrome
Pages 137-151
Prolymphocytic Leukaemia
Pages 155-165
Large Granular Lymphocyte Leukemia
Pages 167-179
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