Cholesterol Crystals in Atherosclerosis and Other Related Diseases

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Cholesterol Crystals in Atherosclerosis and Other Related Diseases

Editore

Springer

Anno

2023

Pagine

504

ISBN

9783031411915

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable ‘liquid’ cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book examines how cholesterol crystals can induce similar injurious processes in other organs including the retina of the eye to cause blindness, in solid cancers causing further tumor growth and in the brain of patients with Alzheimer’s. And lastly, the book addresses various potential therapeutics that disrupt the physiochemical transformation of cholesterol from a liquid to a solid, inhibit its role in triggering inflammation and tissue injury while ushering a path towards targeted therapies.

Cholesterol Crystals in Atherosclerosis and Other Related Diseases will be of interest to cardiologists as well as individuals in various fields of science including crystallography, basic and clinical imaging, cardiac oncology, and drug discovery.

Front Matter

Pages i-xv

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Overview
1. Front Matter
  
  Pages 1-1
  
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2. Atherosclerosis as a Crystalloid Disease: The Discovery of the Role of Cholesterol Crystals in the Formation and Rupture of Atherosclerotic Plaques
  - Stefan Mark Nidorf, George S. Abela, James E. Muller
  Pages 3-14
3. The Cholesterol Crystal Paradigm: Overview of How Cholesterol Crystals Evolve and Induce Traumatic and Inflammatory Vascular Injury
  - Stefan Mark Nidorf, George S. Abela
  Pages 15-26
Physical Properties and Imaging of Cholesterol Crystals: In Vitro
1. Front Matter
  
  Pages 27-27
  
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2. How Innovation in Tissue Preparation and Imaging Revolutionized the Understanding of the Role of Cholesterol Crystals in Atherosclerosis
  - Stanley Flegler, Abigail Vanderberg, Melinda Frame, Carol Flegler, Alicia Withrow, Michael Rich et al.
  Pages 29-48
3. Crystals in Atherosclerosis: Crystal Cholesterol Structures, Morphologies, Formation and Dissolution. What Do We Know?
  - Jenny Capua-Shenkar, Neta Varsano, Howard Kruth, Lia Addadi
  Pages 49-71
Physical Properties and Imaging of Cholesterol Crystals: In Vivo
1. Front Matter
  
  Pages 73-73
  
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2. In Vivo Detection of Cholesterol Crystals in Atherosclerotic Plaque with Optical Coherence Tomography
  - Jinwei Tian, Xiang Peng, Yanwen Zhang, Zhifeng Qin, Peng Zhao, Yani Wang et al.
  Pages 75-87
3. Detecting Cholesterol Crystals Clinically in Spontaneous Aortic Plaque Rupture
  - Kazuhisa Kodama, Chikao Yutani, Sei Komatsu, Satoru Takahashi
  Pages 89-101
Lipidology of Atherosclerosis
1. Front Matter
  
  Pages 103-103
  
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2. Disorders of Cholesterol Trafficking and the Formation of Cholesterol Crystals in Atherosclerotic Plaque
  - Sean P. Gaine, Steven R. Jones, Peter P. Toth
  Pages 105-126
3. Formation of CCs in Endothelial Cells
  - Yvonne Baumer, Lola R. Ortiz-Whittingham, Andrew S. Baez, Tiffany M. Powell-Wiley, William A. Boisvert
  Pages 127-142
Cholesterol Crystals and Tissue Injury
1. Front Matter
  
  Pages 143-143
  
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2. Atherosclerotic Plaque Morphology and the Conundrum of the Vulnerable Plaque
  - Stefan Mark Nidorf, Ryan Madder, Ahmed Elshafie, George S. Abela
  Pages 145-160
3. The Role of Cholesterol Crystals in Plaque Rupture Leading to Acute Myocardial Infarction and Stroke
  - George S. Abela, Kusai Aziz
  Pages 161-185
4. Infarction Without Plaque Rupture
  - Rocco Vergallo, Filippo Crea
  Pages 187-202
5. Athero-Embolism: A Manifestation of Atherosclerosis
  - Rohan M. Prasad, Adolfo Martinez Salazar, Majid Yavari, George S. Abela, Christopher Hanson
  Pages 203-218
6. The Role of Cholesterol Crystals in the Development and Progression of Degenerative Valve Disease
  - Khalid Saeed Al-Asad, Nadine El-Ayache, Abdullah Al-Abcha, George S. Abela
  Pages 219-230
Cholesterol Crystals and Inflammation
1. Front Matter
  
  Pages 231-231
2. 1. Activation of Systemic- and Intracellular Complement by Cholesterol Crystals
    - Nathalie Niyonzima, Claudia Kemper, Bente Halvorsen, Tom Eirik Mollnes, Terje Espevik
    Pages 233-255
  2. Role of CCs and Their Lipoprotein Precursors in NLRP3 and IL-1β Activation
    - Kristiina Rajamäki, Katariina Öörni
    Pages 257-274
  3. Molecular Pathomechanisms of Crystal-Induced Disorders
    - Chongxu Shi, Shrikant R. Mulay, Stefanie Steiger, Hans-Joachim Anders
    Pages 275-296
  4. Omega-3 Fatty Acids Influence Membrane Cholesterol Distribution and Crystal Formation in Models of Atherosclerosis
    - Samuel C. R. Sherratt, Peter Libby, Deepak L. Bhatt, R. Preston Mason
    Pages 297-318
3. Interaction of CCs with Other Crystalloids and Disease Conditions
  1. Front Matter
    
    Pages 319-319
    
    PDF
  2. Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis: Lessons for Cholesterol from the Land of Gout
    - Binita Shah, Gary Ho, Sonal Pruthi, Michael Toprover, Michael H. Pillinger
    Pages 321-349
  3. Calcium Crystals in Arterial Disease
    - Sandeep Banga, Jagadeesh K. Kalavakunta, Oliver Abela, On Topaz
    Pages 351-374
  4. Cholesterol Crystals in Diabetic Retinopathy
    - Yazen A. Shihab, Yvonne Adu Agyeiwaah, Tim F. Dorweiler, Irina Pikuleva, Julia V. Busik, Maria B. Grant
    Pages 375-387
  5. Cholesterol in the Central Nervous System in Health and Disease
    - Ryan Skowronek
    Pages 389-412
  6. Interaction Between Crystals, Inflammation, and Cancer
    - Stefan Mark Nidorf, Abdallah Almaghraby, Yehia Saleh, Venkat R. Katkoori, Zain ul Abideen, Harvey L. Bumpers et al.
    Pages 413-429
  7. The Interaction Between Infection, Crystals, and Cardiovascular Disease
    - Subhashis Mitra, Stefan Mark Nidorf, Manel Boumegouas, George S. Abela
    Pages 431-451
  8. The Potential Role of Cholesterol Crystals in Preeclampsia
    - Robert A. Wild, Zain ul Abideen, Enhua Wang, Ayowale T. Oladeji, Nigel Paneth, Stefan Mark Nidorf et al.
    Pages 453-464
4. Treatment of Cholesterol Crystals
  1. Front Matter
    
    Pages 465-465
    
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  2. Agents That Affect Cholesterol Crystallization and Modify the Risk of Crystal Induced Traumatic and Inflammatory Injury
    - George S. Abela, Sandra Hammer, Xuefei Huang, Julia V. Busik, Stefan Mark Nidorf
    Pages 467-489
5. Back Matter
  
  Pages 491-504

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DA SCONTARE

Front Matter

Overview

Physical Properties and Imaging of Cholesterol Crystals: In Vitro

Physical Properties and Imaging of Cholesterol Crystals: In Vivo

Lipidology of Atherosclerosis

Cholesterol Crystals and Tissue Injury

Cholesterol Crystals and Inflammation

Interaction of CCs with Other Crystalloids and Disease Conditions

Treatment of Cholesterol Crystals

Back Matter

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