Non ci sono recensioni
The History of Cerebrospinal Fluid
Pages 3-16
The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. The first part addresses preclinical aspects such as the history of CSF, as well as the anatomical, physiological, and biological background of this valuable fluid. In addition, CSF collection, its preanalytical and methodological implications, and the increasing number of disease-specific markers in CSF are discussed in detail. Lastly, CSF analyses are put into context with clinical syndromes, demonstrating their diagnostic value in neurological clinical practice. Cerebrospinal Fluid in Clinical Neurology helps readers understand the preanalytical and analytical aspects of CSF diagnostics and offers a valuable reference guide for interpreting CSF results during the clinical work-up for neurological patients.
The History of Cerebrospinal Fluid
Pages 3-16
Anatomy of CSF-Related Spaces and Barriers Between Blood, CSF, and Brain
Pages 17-24
Physiology and Constituents of CSF
Pages 25-34
Techniques, Contraindications, and Complications of CSF Collection Procedures
Pages 35-57
Importance of Pre-analytical Stability for CSF Biomarker Testing
Pages 59-77
Cell Count and Staining
Pages 81-100
Glucose and Lactate
Pages 101-106
CSF Total Protein
Pages 107-109
CSF Albumin: Albumin CSF/Serum Ratio (Marker for Blood-CSF Barrier Function)
Pages 111-114
Immunoglobulins in Cerebrospinal Fluid
Pages 115-129
Detection of Infectious Agents
Pages 131-142
Immunohistochemistry
Pages 143-158
Methods for Biomarker Analysis
Pages 159-171
Acute Infectious Diseases
Pages 175-209
Chronic Infectious Inflammatory Diseases of the Central Nervous System
Pages 211-245
Autoimmune Encephalitis
Pages 247-276
Chronic Noninfectious Inflammatory CNS Diseases
Pages 277-291
CSF Findings in Guillain-Barré Syndrome: Demyelinating and Axonal Acute Inflammatory Polyneuropathies
Pages 293-310
Alterations of the Cerebrospinal Fluid in Chronic Inflammatory Diseases of the Peripheral Nervous System
Pages 311-327
Alzheimer’s Disease and Other Neurodegenerative Disorders
Pages 329-351
Paraneoplastic Neurological Syndromes
Pages 353-385
Laboratory Diagnosis of Subarachnoid Haemorrhage
Pages 387-394
CSF-orrhoea
Pages 395-406
Guidelines on Cerebrospinal Fluid Analysis
Pages 407-428
Sei sicuro di voler eseguire questa azione?