Titolo: Cardiovascular Outcomes Research

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Cardiovascular Outcomes Research

A Clinician’s Guide to Cardiovascular Epidemiology and Clinical Outcomes Trials

Editore

Springer

Anno

2024

Pagine

438

ISBN

9783031549595

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This book provides clinicians with the information needed to effectively interpret the literature from observational and interventional cardiovascular outcomes studies. The book begins by providing a historical context of cardiovascular epidemiology, followed by chapters addressing key concepts in the study of cardiovascular disease such as the types of cardiovascular outcomes studies, basic and evolving design and statistical considerations, current guidelines for reducing atherosclerotic cardiovascular disease risk, surrogate markers of cardiovascular disease, challenges in developing evidence-based recommendations for non-pharmacological interventions, an overview of the pharmaceutical development process, and a detailed discussion of the clinical evidence supporting several factors and their relationships with atherosclerotic cardiovascular disease (lipids, inflammation, hemostasis, heart rhythm, blood pressure, diabetes, obesity, and chronic kidney disease).

Cardiovascular Outcomes Research is a must-have resource for physicians and other clinicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.

Front Matter
Pages i-xvi

Background and Process

    Front Matter
    Pages 1-1

    Evolution of Cardiovascular Outcomes Studies
        Liana L. Guarneiri, Mary R. Dicklin, Kevin C. Maki
    Pages 3-18
    Statistical Methods for Cardiovascular Outcomes Studies
        Aurelian Bidulescu, Steven R. Horbal, Andrew D. Althouse
    Pages 19-66
    Pharmaceutical Development and Approval in the United States of Agents to Influence Cardiovascular Health
        Mary Katherine Cheeley, Laurie Cavendish
    Pages 67-81
    Biomarkers and Imaging Modalities to Detect Subclinical Atherosclerotic Cardiovascular Disease
        Catherine J. McNeal, Philip D. Houck, Nguyen N. Nguyen, James Murchison, Harry Chiang
    Pages 83-110
    An Overview of the Guideline Development Process for Atherosclerotic Cardiovascular Disease Risk Reduction with an Emphasis on Guidelines for Cholesterol and Dyslipidemia Management
        Carl E. Orringer
    Pages 111-116
    Implementation Science: Strategies to Improve Adoption and Adherence to Clinical Practice Guidelines
        Laney K. Jones, Mitchell N. Sarkies, Michael R. Gionfriddo, Samuel S. Gidding, Gerald F. Watts
    Pages 117-141
    Challenges in Developing Evidence-Based Recommendations for Non-Pharmacological Interventions for Atherosclerotic Cardiovascular Disease Risk Reduction
        Kristina S. Petersen
    Pages 143-164

Overview of Current Evidence in Categories of Interventions

    Front Matter
    Pages 165-165
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    Lifestyle Interventions and Atherosclerotic Cardiovascular Disease Outcomes
        Carol F. Kirkpatrick, Kathyrn A. Greaves, Elaine Foster
    Pages 167-200
    Lipids, Lipoproteins, and Cardiovascular Outcomes
        Alexander Sakers, Reed Mszar, Daniel Soffer
    Pages 201-236
    Inflammation and Cardiovascular Outcomes
        Priyanka Satish, Anandita Agarwala
    Pages 237-260
    Thrombosis, Hemostasis, and Cardiovascular Outcomes
        Agastya D. Belur, Shengnan Zheng, Munis Raza, Dinesh K. Kalra
    Pages 261-301
    Blood Pressure and Cardiovascular Outcomes
        Steven A. Greenstein, Joseph A. Diamond
    Pages 303-318
    Pharmacotherapy for Obesity: Recent Evolution and Implications for Cardiovascular Risk Reduction
        Kevin C. Maki, Carol F. Kirkpatrick, David B. Allison, Kishore M. Gadde
    Pages 319-343
    Cardiovascular Disease Risk and Risk Reduction Strategies in Diabetes Mellitus
        Don P. Wilson, Luke Hamilton, Kevin C. Maki
    Pages 345-371
    Cardiac Rhythms and Cardiovascular Outcomes
        Bahij Kreidieh, Ali Keramati, Peter R. Kowey
    Pages 373-400
    Chronic Kidney Disease and Cardiovascular Outcomes
        Gates B. Colbert, Lovy Gaur, Mohamed Elrggal, Hector Madariaga, Edgar Lerma
    Pages 401-429