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For a very long time, cannabis has been one of the most widely used illicit drugs worldwide. However, particularly over the last few years, its legal status has been changing across many geographical jurisdictions. With growing public interest in the medicinal use of cannabis-derived molecules and changing public perception about cannabis, understanding the pharmacological principles underlying the effects of cannabinoids, their therapeutic potential as well as adverse effects has become more important than ever. This has been accompanied by an explosion in scientific research focused on cannabinoids, particularly over the past couple of decades and scientific journals dedicated to cannabis and cannabinoid research have joined the ranks of scientific publishing. Hence, there is a particular need to summarize this growing body of evidence for the wider scientific community. This book aims to address this need by providing a critical overview on a range of topics relevant to understanding the effect of cannabinoids on human health. It is made up of three parts, further divided into various sections. In compiling this book the authors have endeavored to provide a balanced overview of the state-of-the-art evidence regarding cannabinoids with particular relevance to neuropsychiatric conditions. Written by a diverse group of scientists and clinicians, the various chapters and sections provide a comprehensive examination of the adverse effects and therapeutic potential of cannabinoids underpinned by relevant cannabinoid pharmacology. This book will serve as a valuable resource for researchers, clinicians and students.
Endocannabinoid system and cannabinoids : principles of pharmacology
Anna Lauritano, Fabiana Piscitelli, Katarzyna Starowicz, Natalia Malek
Cannabinoids exposure in vulnerable period of brain development. Preclinical evidence
Roberto Frau, Miriam Melis
Cannabinoids and emotionality. Lessons from preclinical research
Brandon Richardson, Courtney Clarke, Francis R. Bambico
Animal models of cannabinoid reward
Sara R. Westbrook, Max W. Melville, Lydia N. Baxter-Potter, Ryan J. McLaughlin
Endocannabinoid-like compounds and their influence in chronic diseases and their comorbidities Focus on N-palmitoylethanolamide
Serena Boccella, Andrea M. Morace, Federica Ricciardi, Antimo Fusco, Michela Perrone, Rosmara Infantino, Ida Marabese, Enza Palazzo, Livio Luongo, Francesca Guida, Francesca Gargano, Sabatino Maione
Lessons learned from studies of the acute effects of cannabinoids on human health
Daniele Cavaleri, Giuseppe Carrà, Francesco Bartoli
Epidemiological evidence of the risk of severe mental disorders in the context of cannabis use
Branko Ristic, Sarah Tosato
Cannabinoids and psychopathology. Evidence from the real world
Franca Ceci, Nicola Ciraselli, Claudia Certelli, Giovanni Martinotti
Synthetic cannabinoids , the largest and most diverse group of novel psychoactive substances
Duccio P. Papanti, Laura Orsolini, John M. Corkery, Stefania Chiappini, Amira Guirguis, Alessandro Vento, Fabrizio Schifano
Is there a role for cannabinoids in cognitive function?
Laura Ferraro
Neurobiological underpinnings of the effects of cannabinoids
Enrico Bonomo, Daniele Pagliaro, Marco Colizzi
Evidence for endocannabinoid -like compo und supplementation for human health
Riccardo Bortoletto, Carla Comacchio, Matteo Balestrieri, Marco Colizzi
Cannabis-based and cannabis-derived therapeutic options
Aisling O’Neill
Cannabis for medical use: considerations on current legislation
Francesca Baratta, Paola Brusa
Cannabinoid research. A look back and a look forward
Vincenzo Di Marzo
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