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Understand and diagnose pathologies of the bladder with this essential reference
With emphasis on the scientific validation of current diagnostic methods and their direct application in clinical practice, Bladder Pathology is a cutting-edge resource that offers contemporary, comprehensive, and evidence-based practice information for pathologists, urologists, oncologists, and other medical professionals.
Readers of the second edition of Bladder Pathology will also find:
Fully updated to reflect the latest research and evidence, Bladder Pathology is an indispensable resource for pathologists, urologists, and other clinicians.
Liang Cheng, MD, MS, is Professor and Vice Chair of Pathology, Professor of Surgery/Urology, Director of Anatomic Pathology, Director of Molecular Pathology in the Department of Pathology and Laboratory Medicine at the Brown University Warren Alpert Medical School and Brown University Health, Providence, Rhode Island. He also serves as the Associate Director of the Legorreta Cancer Center at Brown University. Dr. Cheng has published over 1,200 peer-reviewed SCI articles (h-index: 133) in high-impact scientific journals. He has been honored with prestigious awards, including the Arthur Purdy Stout Annual Award from the Society of Surgical Pathologists for his outstanding contributions to surgical pathology and the Koss Medal Award from the International Society of Urological Pathology (ISUP) for lifetime achievement in urological pathology. Dr. Cheng is the incoming President (2025-2027) of the International Society of Urological Pathology.
Antonio Lopez-Beltran, MD, PhD, is Professor of Anatomic Pathology, Department of Morphological Sciences, Cordoba University Medical School, Cordoba, Spain. Antonio’s work is centered in genitourinary tumor pathology with emphasis on pathology of the urinary bladder. He is Past Chairman of the European Section of Uropathology of the European Association of Urology and Past Chairman of the Uropathology Working Group of the European Society of Pathology. He serves on the editorial boards of several international pathology journals.
Rodolfo Montironi, MD, IFCAP, is Professor of Anatomic Pathology, Molecular Medicine and Cell Therapy Foundation, Polytechnic University of the Marche Region, Italy. Rodolfo’s work is centered in genitourinary tumor pathology. He is a Past President of the International Society of Urological Pathology. He serves on the editorial boards of several international pathology and urology journals, including European Urology.
Preface vii
1 Normal Anatomy and Histology 1
2 Inflammatory and Infectious Conditions 19
3 Urothelial Metaplasia and Hyperplasia 47
4 Polyps and Other Nonneoplastic Benign Conditions 75
5 Benign Epithelial Tumors 91
6 Flat Urothelial Lesions with Atypia and Urothelial Dysplasia 105
7 Urothelial Carcinoma In Situ 121
8 Bladder Cancer: General Features 147
9 Classification and Grading of Bladder Cancer 175
10 Stage pT1 Urothelial Carcinoma 209
11 Staging of Bladder Cancer 241
12 Histological Variants (Subtypes) of Urothelial Carcinoma 263
13 Bladder Tumors with Inverted Growth 311
14 Bladder Carcinoma in Specific Clinical Setting 329
15 Sarcomatoid Carcinoma (Carcinosarcoma) 345
16 Adenocarcinoma and Its Putative Precursors and Variants 373
17 Squamous Cell Carcinoma and Other Squamous Lesions 397
18 Neuroendocrine Tumors 415
19 Handling and Reporting of Bladder Specimens 449
20 Congenital Disorders and Pediatric Neoplasms 473
21 Soft Tissue Tumors 497
22 Lymphoid and Hematopoietic Tumors 537
23 Other Rare Tumors 547
24 Secondary Tumors 561
25 Treatment Effects 573
26 Pathology of the Urachus 595
27 Pathology of Renal Pelvis, Ureter, and Urethra 611
28 Diagnostic Immunohistochemistry 649
29 Tissue-Based Biomarkers for Prognosis and to Guide Therapy for Bladder Cancer 679
30 Molecular Pathology of Bladder Cancer 717
31 Molecular Determinants for Tumor Prognosis and Targeted Therapy 761
32 Urine-Based Biomarkers 787
33 Evaluation of Hematuria and Urinalysis 819
34 Urinary Cytology 829
Index 857
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