Front Matter

Pages i-xvii

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Basic Studies: Tumor Mechanisms and Tissue Biomarkers

1. Front Matter

   Pages 1-1

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2. The Role of the Tumor Microenvironment in Regulating Angiogenesis

   • Randolph S. Watnick

   Pages 3-15

3. Tissue-Based Biomarkers of Tumor-Vascular Interactions

   • Lars A. Akslen

   Pages 17-30

4. Molecular Phenotypes of Endothelial Cells in Malignant Tumors

   • Vladan Milosevic, Reidunn J. Edelmann, Johanna Hol Fosse, Arne Östman, Lars A. Akslen

   Pages 31-52

5. Lymphatics in Malignant Tumors

   • Marek Wagner, Helge Wiig

   Pages 53-62

6. Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?

   • Cédric Zeltz, Roya Navab, Ning Lu, Marion Kusche-Gullberg, Ming-Sound Tsao, Donald Gullberg

   Pages 63-89

7. Tissue Architecture in Cancer Initiation and Progression

   • Susan E. Leggett, Celeste M. Nelson

   Pages 91-107

8. Tumor-Fibroblast Interactions in Carcinomas

   • Harsh Dongre, Daniela Elena Costea

   Pages 109-124

9. Stromal PDGF Receptors; Impact on Prognosis and Response to Treatment

   • Carina Strell, Arne Östman

   Pages 125-138

10. Inflammation and Cancer: Lipid Autacoid and Cytokine Biomarkers of the Tumor Microenvironment

    • Molly M. Gilligan, Bruce R. Zetter, Dipak Panigrahy

    Pages 139-158

11. Role of Lymphocytes in Cancer Immunity and Immune Evasion Mechanisms

    • Kushi Kushekhar, Stalin Chellappa, Einar M. Aandahl, Kjetil Taskén

    Pages 159-182

12. Drivers of EMT and Immune Evasion

    • Rolf A. Brekken, Katarzyna Wnuk-Lipinska

    Pages 183-194

13. Inflammatory Biomarkers for Cancer

    • Alexandre Corthay, Guttorm Haraldsen

    Pages 195-205

14. Tumor Infiltrating Lymphocytes in Breast Cancer: Implementation of a New Histopathological Biomarker

    • Giuseppe Floris, Glenn Broeckx, Asier Antoranz, Maxim De Schepper, Roberto Salgado, Christine Desmedt et al.

    Pages 207-243

15. Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments

    • Divya Ramchandani, Tyler P. El Rayes, Dingcheng Gao, Nasser K. Altorki, Thomas R. Cox, Janine T. Erler et al.

    Pages 245-266

16. The Role of Platelets in the Tumor Microenvironment

    • Qiuchen Guo, Harvey G. Roweth, Kelly E. Johnson, Sandra S. McAllister, Joseph E. Italiano Jr., Elisabeth M. Battinelli

    Pages 267-281

17. Neurogenesis in the Tumor Microenvironment

    • Heidrun Vethe, Ole Vidhammer Bjørnstad, Manuel Carrasco, Lars A. Akslen

    Pages 283-293

18. Neuropilins as Cancer Biomarkers: A Focus on Neuronal Origin and Specific Cell Functions

    • Dakshnapriya Balasubbramanian, Yao Gao, Diane R. Bielenberg

    Pages 295-306

19. The Role of AXL Receptor Tyrosine Kinase in Cancer Cell Plasticity and Therapy Resistance

    • Maria L. Lotsberg, Kjersti T. Davidsen, Stacey D’Mello Peters, Gry S. Haaland, Austin Rayford, James B. Lorens et al.

    Pages 307-327

20. Basic Studies: Tumor Mechanisms and Tissue Biomarkers

    1. Modeling the Tumor Microenvironment in Patient-Derived Xenografts: Challenges and Opportunities

       • Katrin Kleinmanns, Christiane Helgestad Gjerde, Anika Langer, Vibeke Fosse, Elvira García de Jalón, Calum Leitch et al.

       Pages 329-344

    2. Use of Imaging Mass Cytometry in Studies of the Tissue Microenvironment

       • Ida Herdlevær, Lucia Lisa Petrilli, Fatime Qosaj, Maria Vinci, Dario Bressan, Sonia Gavasso

       Pages 345-364

    3. Artificial Intelligence in Studies of Malignant Tumours

       • André Pedersen, Ingerid Reinertsen, Emiel A. M. Janssen, Marit Valla

       Pages 365-375

21. Clinical Applications: Organ Related Studies of Biomarkers and Therapy

    1. Front Matter

       Pages 377-377

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    2. The Tumor and Its Microenvironment as Complementary Sources of Cancer Biomarkers

       • Roopali Roy, Emily Man, Rama Aldakhlallah, Emma Rashes, Marsha A. Moses

       Pages 379-400

    3. Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Phenotypes and Progress in Breast Cancer

       • Elisabeth Wik, Lise M. Ingebriktsen, Lars A. Akslen

       Pages 401-424

    4. MR-Derived Biomarkers for Cancer Characterization

       • Eugene Kim, Morteza Esmaeili, Siver A. Moestue, Tone F. Bathen

       Pages 425-440

    5. The Influence of Tissue Architecture on Drug Response: Anticancer Drug Development in High-Dimensional Combinatorial Microenvironment Platforms

       • Tiina A. Jokela, Eric G. Carlson, Mark A. LaBarge

       Pages 441-452

    6. Models of Tumor Progression in Prostate Cancer

       • Waqas Azeem, Yaping Hua, Karl-Henning Kalland, Xisong Ke, Jan Roger Olsen, Anne Margrete Oyan et al.

       Pages 453-465

    7. Prostate Cancer Biomarkers: The Old and the New

       • Anette L. Magnussen, Ian G. Mills

       Pages 467-482

    8. The Role of the Microenvironment in Endometriosis: Parallels and Distinctions to Cancer

       • Michael S. Rogers

       Pages 483-496

    9. Tumor-Vascular Interactions in Non-Small Cell Lung Cancer

       • Maria Ramnefjell, Lars A. Akslen

       Pages 497-508

    10. Tumor–Host Interactions in Malignant Gliomas

        • Lina Leiss, Ercan Mutlu, Mohummad Aminur Rahman, Mette Hartmark Nilsen, Per Øyvind Enger

        Pages 509-518

    11. The Role of the Microenvironment in Tumor Promoting Stress Responses

        • Hanna Dillekås, Cornelia Schuster, Kjersti T. Davidsen, Oddbjørn Straume

        Pages 519-536

    12. Vascular Co-option in the Brain Tumor Microenvironment

        • Sarah Wang, Andrew C. Dudley

        Pages 537-547

    13. Biomarker Panels and Contemporary Practice in Clinical Trials of Personalized Medicine

        • Nina Louise Jebsen, Irini Ktoridou-Valen, Bjørn Tore Gjertsen

        Pages 549-562

    14. Cancer Biomarkers: A Long and Tortuous Journey

        • Wen Jing Sim, Kian Chung Lee, Jean Paul Thiery

        Pages 563-580

22. Back Matter

    Pages 581-593